Compound Profile
Hydroxyzine
Compound profile with evidence, safety, and practical fit.
Safety context — Current U. Details
- Evidence
- Limited evidence
- Typical onset
- Varies by prep
- Safety rating
- Safety context: Use caution
- Best for
- Histamine H1 Receptor Antagonism, Sedating Antihistamine Effects
Safety
Safety & Cautions
Current U. S.
Elevated caution
Caution level: Elevated. One caution category applies — read it before use.
- Interaction-AwareMedication or interaction context is explicitly noted.
Evidence Summary
Profile-wide ·C LimitedEvidence lens
Read as directional context, not settled clinical proof.
Human clinical evidence: Present in source signals
Mechanistic / preclinical: Mechanism mapped
Research maturity: Emerging research — main contexts: Histamine H1 Receptor Antagonism · Sedating Antihistamine Effects
Safety boundary: Safety note available — Current U.
Confidence estimate based on the design quality and consistency of published clinical trials.
Hydroxyzine has a limited evidence rating.
Grade C: Limited Evidence
Evaluation of methodological rigor, population reach, and evidence alignment.
- Design Match
- Meta analysis
- Risk of Bias
- Low
- Consistency
- Consistent
How evidence grades work
Each grade reflects the strength and consistency of published human evidence — not marketing claims. Grades are based on study count, design quality, effect size, consistency, and recency.
- Strong
- Multiple RCTs, consistent direction, adequate effect size
- Moderate
- Some RCTs or consistent observational data in humans
- Preliminary / Mixed
- Animal or in-vitro only, or conflicting human data
- Traditional / Theoretical
- Traditional use only; no controlled human trials
Clinical Study Summaries (4)3 human evidence sources · 2 human trials · Participant totals not consistently reported · Consistency not yet classifiable
Filter by study class
Showing 4 of 4 studies.
What the evidence actually shows
This table contains 4 structured sources, including 3 human evidence sources; 2 are human trials.
| Study | Design | N | Dose | Duration | Population | Outcome | Result & magnitude | Source |
|---|---|---|---|---|---|---|---|---|
Background | Meta-analysis Statistically combines results from multiple eligible studies; confidence still depends on the quality, consistency, and directness of those studies. | — | — | — | — | — | A 2010 Cochrane review of five studies involving 884 participants found hydroxyzine showed benefit versus placebo for generalized anxiety disorder, but the authors judged the evidence insufficient to recommend it as a reliable first-line treatment because of limited study quantity and risk of bias. | PubMed → |
Background | Randomized controlled trial Randomly assigns participants to interventions or controls, reducing many sources of bias when the trial is conducted well. | — | — | — | — | — | A four-week randomized double-blind placebo-controlled study of 244 primary-care patients with generalized anxiety disorder reported greater improvement in Hamilton Anxiety Rating Scale scores with hydroxyzine than placebo. | PubMed → |
Background | Randomized controlled trial Randomly assigns participants to interventions or controls, reducing many sources of bias when the trial is conducted well. | — | — | — | — | — | A 12-week randomized double-blind placebo-controlled study of 334 adults with generalized anxiety disorder reported greater improvement in Hamilton Anxiety Rating Scale scores with hydroxyzine than placebo. | PubMed → |
Background | Other / unclear The study design is not yet classified clearly enough to infer its place in the evidence hierarchy. | — | — | — | — | — | A 2026 U.S. DailyMed label lists hydroxyzine for symptomatic relief of anxiety and tension associated with psychoneurosis and as an adjunct in organic disease states in which anxiety is manifested, as well as pruritus and peri-anesthetic sedation. | Source → |
Dosing
- No standardized dose
- No standardized dose is established for this ingredient in our source data. Preparations differ widely, so follow the standardization on the product you actually have and speak to a clinician before starting.
Botanical Context
Source botanicals and comparison guides related to Hydroxyzine.
Compare & Sourcing
Compare side-by-side tradeoffs or verify active marker guidelines.
Review available sources for Hydroxyzine
Independent database mapping — evaluated separately from safety and efficacy scores.
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Safety first · Harm reduction
This information is educational and not medical advice. Start low, avoid risky combinations, and consult a licensed clinician before making health decisions—especially if you use medications, have diagnosed conditions, or are pregnant/breastfeeding.
Learn how we evaluate confidence, safety, and intensity on the methodology page.
Founder & Head Researcher · Oak Ridge, TN · Last reviewed August 2026
Editorial Review
Checked against primary sources, cited evidence, and contraindication language before publication. Evidence claims, safety language, and affiliate modules are reviewed independently. Not personal medical advice.
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