Editorial library · Research and reading

Articles

Read research notes, evidence reviews, regulatory updates, and editorial deep dives. Guides are for decisions; Learn is for concepts; Articles are for deeper reading.

Latest

Recent articles

261 published pieces

Supplement Safety

7 Supplements Linked to Liver Injury: What the Evidence Shows

Seven herbs and extracts with published liver-injury cases: ashwagandha, turmeric, black cohosh, green tea extract, gotu kola, Chinese skullcap and fo-ti. What the evidence establishes, where attribution is uncertain, and which symptoms need urgent attention.

Read article
Stress and anxiety

Ashwagandha Benefits, Sleep & Stress Evidence: What the Science Actually Shows

Evidence-based 2026 review of ashwagandha for stress, anxiety and sleep, including meta-analyses, formulation limits, study-dose context, thyroid concerns, rare liver injury and medication safety.

Read article
Metabolic health

Berberine: Blood Sugar, Lipids & Weight — Evidence Review

Evidence review of berberine for glucose, lipids, and weight, with clear limits on the metformin comparison, trial-dose context, drug interactions, and long-term uncertainty.

Read article
Cognitive health

Creatine for Brain Health: Cognition, Sleep Loss, Mood & Safety — 2026 Review

Evidence-first 2026 review of creatine for cognition, memory, sleep deprivation, depression, brain energy metabolism, and kidney safety, including corrected meta-analytic and citation caveats.

Read article
Immune health

Elderberry for Colds & Flu: What Human Trials Actually Show

An evidence-first review of elderberry for respiratory symptoms: small randomized trials, uncertain prevention and treatment benefits, cytokine-storm misinformation, product differences, and safety.

Read article
Cognitive health

Ginkgo Biloba 240 mg: What the Evidence Actually Supports

Evidence-first 2026 review of Ginkgo biloba 240 mg and EGb 761: dementia symptom trials, negative prevention data, MCI, healthy cognition, product directness, bleeding/warfarin evidence, and why 240 mg is not a universal dose.

Read article

Full archive

Browse by category

The complete archive stays here, but categories expand only when you need them instead of rendering every article as a full card.

Adaptogens (2)
Alkaloids (5)
Anxiety & Sleep (35)
Kava for Anxiety: Does It Work for Social Anxiety? Evidence & Liver Safety2026-10-11Magnesium Glycinate Nightly: Sleep Evidence & Long-Term Safety — 2026 Review2026-10-11Passionflower for Anxiety & Sleep: Benefits, Dosage & Evidence2026-10-04Lemon Verbena for Sleep: Two Positive RCTs, Product Specificity, and Limits2026-09-30Ziziphus spinosa (Suan Zao Ren) for Sleep: Human Evidence and Limits2026-09-30Nicotine, Vaping and Sleep: What the Evidence Shows2026-09-24Anxiety and Sleep: Insomnia, Hyperarousal, CBT-I and the Bidirectional Evidence2026-09-22Valerian Root for Sleep: Does It Work? Evidence Review (2026)2026-09-22The 90-Minute Sleep Cycle Myth: Sleep Cycles Are Real, but They Are Not a Timer2026-09-04Bedroom Air Quality and Sleep: Ventilation, CO₂, Pollution, and What the Evidence Actually Shows2026-09-04Cannabis and Sleep: What the 2025–2026 Evidence Actually Shows2026-09-04Chamomile for Sleep: What the Trials and Meta-Analyses Say2026-09-04Chronic Pain and Sleep: Why Poor Sleep Can Make Pain Worse2026-09-04Depression and Sleep: Insomnia, Hypersomnia, CBT-I and the Bidirectional Evidence2026-09-04How Much Sleep Do Adults Need? Why 7+ Hours Is Not an Exact Eight-Hour Rule2026-09-04Jet Lag: Light, Melatonin, Sleep Timing, and Why Direction Matters2026-09-04Lavender for Sleep: What the 2026 Meta-Analysis Actually Shows2026-09-04Menopause and Sleep: Hot Flashes, Insomnia, Sleep Apnea and What Actually Helps2026-09-04Mouth Taping for Sleep: What the Evidence and Safety Reviews Actually Show2026-09-04Night Owl or Delayed Sleep-Wake Phase Disorder? How to Tell the Difference2026-09-04Diphenhydramine and Doxylamine for Sleep: What OTC 'PM' Products Actually Do2026-09-04Passionflower for Sleep: Human Trials, Insomnia Evidence, and Limits2026-09-04Pregnancy and Postpartum Sleep: Insomnia, Sleep Apnea, Restless Legs and What Actually Helps2026-09-04PTSD, Nightmares and Sleep: CBT-I, Imagery Rehearsal and What the Evidence Actually Shows2026-09-04Saffron for Sleep: Evidence, Insomnia Trials, and Limits2026-09-04Shift Work Sleep Disorder: What the New AASM Guidance Actually Recommends2026-09-04Sleep Environment Evidence Guide: Light, Noise, Temperature, Air, and Position2026-09-04Sleep Inertia: Why You Feel Groggy After Waking and What Actually Helps2026-09-04Best Sleep Position? Why the Answer Depends on Sleep Apnea, Reflux, and the Actual Problem2026-09-04Snoring vs Sleep Apnea: When Noise Is a Symptom—and When It Is a Disorder2026-09-04Tart Cherry for Sleep: What Human Trials Actually Show2026-09-04Teen Sleep and School Start Times: What Later Starts Actually Change2026-09-04Tinnitus and Sleep: Insomnia, CBT-I, Sound and the Evidence2026-09-04Magnesium + L-Theanine for Sleep: Evidence and Combination Limits2026-08-12L-Theanine: Benefits, Dose, Sleep & Focus — 2026 Evidence Review2026-08-01
Cognitive health (8)
Compounds & Cognition (5)
Compounds & Focus (1)
Compounds & Healthy Aging (2)
Compounds & Neurodevelopment (1)
Compounds & Pain (2)
Compounds & Performance (1)
Field Notes (11)
General (2)
Harm Reduction (5)
Herbs & Anxiety (1)
Herbs & Cognition (1)
Herbs & Metabolic Health (1)
Herbs & Neuropharmacology (1)
Immune health (1)
Mental-Health (1)
Metabolic health (1)
Mood (1)
Novel Psychoactive Substances (4)
Research (13)
Sleep (42)
Sleep Interventions Evidence Matrix: Supplements, Habits, Circadian Tools, and Red Flags2026-09-22Advanced Sleep-Wake Phase Disorder: Early Bedtimes, Early Waking and When It Is More Than Just Being a Morning Person2026-09-04Blue Light, Screens and Sleep: What Actually Matters2026-09-04CBT-I vs Sleep Supplements: What the Evidence Actually Supports2026-09-04CPAP vs Oral Appliance for Sleep Apnea: Which Works Better?2026-09-04Daytime Sleepiness vs Fatigue: They Feel Similar but Point to Different Problems2026-09-04Delayed Sleep-Wake Phase vs Insomnia: When the Clock Is the Problem2026-09-04Exploding Head Syndrome: The Painless Sleep-Transition 'Bang' and What the Evidence Says2026-09-04Eye Masks, Earplugs, and Sleep: Strongest in Noisy Clinical Environments2026-09-04Home Sleep Apnea Test vs Polysomnography: What Each Test Can Miss2026-09-04Hops for Sleep: Most Human Evidence Is Really Valerian + Hops Evidence2026-09-04Hypersomnolence vs Insufficient Sleep: When Daytime Sleepiness Needs a Deeper Workup2026-09-04Idiopathic Hypersomnia vs Narcolepsy: Sleep Inertia, Long Sleep, MSLT and the Diagnostic Gray Zone2026-09-04Lemon Balm for Sleep: Promising Extract Data, but Not One Proven Herb Effect2026-09-04Medications and Sleep: Why Sedating, Activating and Sleep-Architecture Effects Are Not the Same Thing2026-09-04Migraine and Sleep: Insomnia, Sleep Quality, CBT-I and the Bidirectional Evidence2026-09-04Mindfulness for Insomnia: Better Than Waitlist Is Not the Same as Better Than CBT-I2026-09-04Music for Sleep: Better Subjective Sleep, Much Weaker Objective Evidence2026-09-04Narcolepsy: Excessive Daytime Sleepiness, Cataplexy, MSLT and What Actually Separates It From Being Tired2026-09-04Nasal Obstruction, Snoring and Sleep Apnea: What Nasal Strips, Dilators and Nasal Surgery Can—and Cannot—Fix2026-09-04Night Terrors vs Nightmares: NREM Arousal, Dream Recall and How to Tell Them Apart2026-09-04Nocturia and Sleep: Why Waking to Urinate Is Not Just a Bladder Problem2026-09-04Omega-3 and Sleep: Why the Meta-Analyses Do Not Tell One Simple Story2026-09-04Oral GABA for Sleep: Human Evidence Is Still Very Limited2026-09-04REM Sleep Behavior Disorder: Dream Enactment, Safety, Melatonin and the Neurologic Link2026-09-04Restless Legs, Iron and Sleep: Why Ferritin Changes the Question2026-09-04Sleep Apnea in Women: Why OSA Can Be Missed2026-09-04Sleep Apnea vs Insomnia: Why the Difference Matters2026-09-04Sleep Bruxism and Sleep Apnea: What Teeth Grinding Does—and Does Not—Tell You2026-09-04Sleep Bruxism: Teeth Grinding, Jaw Pain, Mouthguards, Sleep Apnea and What the Evidence Actually Shows2026-09-04Sleep Debt and Recovery: Why One Good Night Does Not Reset Every Outcome2026-09-04Sleep in Older Adults: Aging, Insomnia, CBT-I, Apnea and Medication Risk2026-09-04Sleep Paralysis: REM Atonia, Hallucinations, Narcolepsy and What Actually Helps2026-09-04Sleep-Related Eating Disorder: Parasomnia, Amnesia, Zolpidem and How It Differs From Night Eating2026-09-04Sleep-Related Hallucinations: Hypnagogic vs Hypnopompic Experiences2026-09-04Sleepwalking and NREM Parasomnias: Triggers, Safety, Diagnosis and What Actually Helps2026-09-04Teen and Adolescent Sleep: Circadian Delay, School Start Times, Insomnia and CBT-I2026-09-04Vitamin D and Sleep: A Sleep-Quality Signal, Not a Universal Insomnia Treatment2026-09-04Warm Bath or Shower Before Bed: The Sleep-Onset Evidence and Its Limits2026-09-04Weekend Catch-Up Sleep: Can You Repay Sleep Debt?2026-09-04Weighted Blankets for Sleep: Promising Adult Data, Unstable Pooled Evidence2026-09-04White Noise and Sleep: Newer Meta-Analysis, Pink Noise, and the Limits of Sound Masking2026-09-04
Sleep safety (1)
Sleep Science (22)
Caffeine and Sleep: How Late Is Too Late? Evidence on Timing and Dose2026-09-24Exercise for Insomnia: What the 2024–2025 Evidence Actually Shows2026-09-05Insomnia Evidence Guide: Why You Cannot Sleep, What to Check, and What Actually Helps2026-09-05Why Am I Still Tired After 8 Hours of Sleep? A Guide to Non-Restorative Sleep2026-09-05Sleep Hygiene vs CBT-I: Why Basic Sleep Tips Are Not the Same as Insomnia Treatment2026-09-05Why Do I Wake Up at 3 AM? An Evidence-First Guide to Middle-of-the-Night Awakenings2026-09-055-HTP for Sleep: Limited Evidence, Serotonin Pathways & Safety2026-09-04Alcohol and Sleep: Why Falling Asleep Faster Can Mean Worse Sleep2026-09-04Exercise Timing and Sleep: Is Working Out at Night Actually Bad?2026-09-04Insomnia vs Sleep Deprivation: Same Tired Feeling, Different Problem2026-09-04L-Tryptophan for Sleep: What the Evidence Actually Shows2026-09-04Melatonin Timing vs Dose: Why Clock Time May Matter More Than More Milligrams2026-09-04Morning Light and Sleep Timing: Why Light Works Differently by Clock Time2026-09-04Naps and Nighttime Sleep: When Napping Helps—and When It Can Backfire2026-09-04Sleep Onset vs Sleep Maintenance: Why the Difference Changes the Evidence2026-09-04Sleep Regularity: Why Consistent Timing May Matter Beyond Sleep Duration2026-09-04Why Sleep Supplement Formulations Are Not Interchangeable2026-09-04Sleep Temperature and Cooling: What Heat, Bedding, and Cooling Studies Show2026-09-04How Accurate Are Sleep Trackers? What 2025–2026 Reviews Say2026-09-04Subjective vs Objective Sleep: Why Your Sleep Can Feel Worse Than the Numbers2026-09-04Time-Restricted Eating and Sleep: Why the Evidence Looks Contradictory2026-09-04Why Sleep Studies Disagree: 9 Reasons the Evidence Looks Messy2026-09-04
Stress and anxiety (1)
Substance Use & Harm Reduction (88)
1P-LSD: Masterclass Monograph — Human Pharmacokinetics, LSD Prodrug Evidence & Safety2026-10-054-AcO-DMT (Psilacetin): Masterclass Monograph — Metabolism, Psychedelic Risk & Evidence Gaps2026-10-054-FA (4-Fluoroamphetamine): Cerebral Hemorrhage, Cardiac Toxicity & Deaths2026-10-054-HO-MET (Metocin): Masterclass Monograph — Human Toxicology, Metabolism & Testing2026-10-054F-MPH (4-Fluoromethylphenidate): Intoxication, Fatality & Stimulant Evidence2026-10-055-MeO-MiPT (Moxy): Masterclass Monograph — Toxicology, Metabolism & Serotonergic Risk2026-10-05Benzofuran RCs & Entactogens: 6-APB, 5-APB, 5-MAPB and Related Compounds2026-10-05Phenazolam (Clobromazolam): Emerging Designer Benzo Masterclass2026-10-05Desalkylgidazepam (Bromonordiazepam): Long-Acting Designer Benzo Masterclass2026-10-05Dissociative Withdrawal & Recovery: Evidence and Safety2026-10-05MDMA & Benzofuran Recovery: Evidence and Support2026-10-05Eutylone (bk-EBDB): Synthetic Cathinone, Fatalities & Molly Mislabeling2026-10-05NBOMe & NBOH Psychedelics: 25I-NBOMe, 25E-NBOH, Seizures & Severe Toxicity2026-10-05NEP (N-Ethylpentedrone): Synthetic Cathinone Masterclass — Toxicology, Dependence & Testing2026-10-05Non-Cathinone RC Stimulants: 4F-MPH, 3-FPM, Fluoroamphetamines & Related Compounds2026-10-05Qualone Withdrawal & Recovery: Evidence and Safety2026-10-05Psychedelic Recovery: Persistent Effects and Support2026-10-05RC Dissociatives: 2F-DCK, DCK, O-PCE, FXE, DMXE and PCP/PCE Analogues2026-10-05RC Psychedelics: 1P-LSD, 4-AcO-DMT, 5-MeO-MiPT and Other Novel Tryptamines/Lysergamides2026-10-05Research Chemicals & New Psychoactive Substances: Evidence Map, Major Classes & Risks2026-10-05Synthetic Cannabinoid Withdrawal & Recovery2026-10-05Synthetic Cannabinoids / Spice: MDMB-4en-PINACA, ADB-BUTINACA and Modern High-Potency SCRAs2026-10-05Synthetic Cathinones & RC Stimulants: NEP, alpha-PiHP, MDPHP and Related Compounds2026-10-052-MMC (2-Methylmethcathinone): Complete Human Toxicology, Metabolism & Safety Monograph2026-10-0325E-NBOH (NBOH-2C-E): Complete Toxicology, Metabolism & Safety Monograph2026-10-032F-2oxo-PCE (CanKet): Complete Toxicology, FXE Isomer Confusion & Safety Monograph2026-10-033-CMC (3-Chloromethcathinone): Complete Human Toxicology, Metabolism & Safety Monograph2026-10-033-FPM (3-Fluorophenmetrazine): Complete Human Toxicology, Pharmacokinetics & Dependence Monograph2026-10-035F-MDMB-PICA (5F-MDMB-2201): Complete Fatal Toxicology, Dependence & Safety Monograph2026-10-036-APB (Benzofury): Complete Toxicology, Fatalities, 5-HT2B Risk & Dependence Monograph2026-10-036-MAPB: Complete Benzofuran Pharmacology, Metabolism & Safety Monograph2026-10-03ADB-BUTINACA: Complete Fatal Toxicology, Dependence, Withdrawal & Safety Monograph2026-10-03α-PiHP (Alpha-Pyrrolidinoisohexanophenone): Complete Human Pharmacology, Fatality & Dependence Monograph2026-10-03Diclazepam: Complete Evidence, Active Metabolites, Dependence, Withdrawal & Safety Monograph2026-10-03Etizolam: Complete Evidence, Counterfeit Pills, Dependence, Withdrawal & Safety Monograph2026-10-03Flubromazepam: Complete Evidence, Long Persistence, Dependence, Withdrawal & Safety Monograph2026-10-03Flunitrazolam: Complete Evidence, Metabolism, Detection, Dependence & Safety Monograph2026-10-03MDPHP: Complete Human Toxicology, Fatalities, Metabolism & Dependence Monograph2026-10-03MDPiHP: Complete Emerging Stimulant, Human Metabolism & Forensic Safety Monograph2026-10-03Meclonazepam: Complete Evidence, Metabolism, Toxicology, Dependence & Safety Monograph2026-10-03Metizolam: Complete Evidence, Metabolism, Toxicology, Dependence & Safety Monograph2026-10-03Norflurazepam: Complete Active-Metabolite, Toxicology, Dependence & Safety Monograph2026-10-03Phenazepam: Complete Evidence, Pharmacology, Toxicology, Dependence & Safety Monograph2026-10-03Pyrazolam: Complete Evidence, Acute Poisoning, Dependence, Withdrawal & Safety Monograph2026-10-03Rilmazafone: Complete Prodrug, Metabolism, Fatal Toxicology & Safety Monograph2026-10-031cP-LSD: Complete Prodrug Evidence, Toxicology Gaps & Safety Monograph2026-10-022-Methyl-AP-237 & AP-238: Complete Toxicology, Overdose, Dependence & Safety Monograph2026-10-0225I-NBOMe: Complete Toxicology, Seizures, Hyperthermia, Fatalities & Safety Monograph2026-10-022C-B-FLY: Complete Sparse-Evidence Pharmacology, Mislabeling & Safety Monograph2026-10-022F-DCK (2-Fluorodeschloroketamine): Complete Toxicology, Deaths, Dependence & Safety Monograph2026-10-023-HO-PCP (3-Hydroxyphencyclidine): Complete Toxicology, Dependence & Safety Monograph2026-10-023-MeO-PCE (3-Methoxyeticyclidine): Complete Toxicology, Deaths, Metabolism & Safety Monograph2026-10-023-MMC (Metaphedrone): Complete Human Toxicology, Dependence & Safety Monograph2026-10-024-MMC (Mephedrone): Complete Human Toxicology, Dependence, Pharmacokinetics & Safety Monograph2026-10-025-APB (5-Benzofury): Complete Toxicology, Fatalities, Dependence & Safety Monograph2026-10-025F-ADB (5F-MDMB-PINACA): Complete Fatal Toxicology, Withdrawal & Safety Monograph2026-10-027-Hydroxymitragynine (7-OH): Complete Evidence, Toxicology, Dependence, Withdrawal & Safety Monograph2026-10-02AL-LAD: Complete LSD-Analogue Pharmacology, Fatality & Safety Monograph2026-10-02α-PHP (Alpha-Pyrrolidinohexanophenone): Complete Toxicology, Dependence & Safety Monograph2026-10-02α-PVP (Flakka): Complete Toxicology, Psychosis, Dependence & Forensic Safety Monograph2026-10-02Bromazolam: Complete Evidence, Toxicology, Dependence, Withdrawal & Safety Monograph2026-10-02Brorphine: Complete Toxicology, Overdose, Dependence, Withdrawal & Safety Monograph2026-10-02Buzzers Cat’s Claw: Hidden Opioids, Lab Findings, Dependence, Withdrawal & Safety Monograph2026-10-02Cat’s Claw & Kava Hidden-Opioid Products: Evidence, Overdose, Dependence & Product-Safety Monograph2026-10-02Clonazolam: Complete Toxicology, Blackouts, Dependence, Withdrawal & Safety Monograph2026-10-02Cychlorphine (N-Propionitrile Chlorphine): Complete Toxicology, Overdose & Safety Monograph2026-10-02Deschloroketamine (DCK/DXE): Complete Toxicology, Dependence & Safety Monograph2026-10-02Designer Benzodiazepines (RC Benzos): Complete Toxicology, Dependence, Withdrawal & Safety Monograph2026-10-02Designer Synthetic Opioids Beyond Fentanyl & Nitazenes: Master Harm-Reduction Monograph2026-10-02MGM-15 (Dihydro-7-Hydroxymitragynine): Complete Pharmacology, Dependence, Withdrawal & Safety Monograph2026-10-02DMXE (Deoxymethoxetamine): Complete Sparse-Evidence Pharmacology & Safety Monograph2026-10-02Ethylbromazolam: Emerging Designer Benzodiazepine Toxicology, Counterfeit Pills & Safety Monograph2026-10-02Flualprazolam: Complete Counterfeit Xanax, Toxicology, Dependence & Safety Monograph2026-10-02Flubromazolam: Complete Prolonged Intoxication, Pharmacokinetics, Dependence & Safety Monograph2026-10-02Fluorexetamine (FXE/3F-2-oxo-PCE): Complete Toxicology, Isomer Confusion & Safety Monograph2026-10-02Isotonitazene: Complete Toxicology, Overdose, Dependence, Withdrawal & Safety Monograph2026-10-02MDMB-4en-PINACA: Complete Seizure, Fatal Toxicology, Withdrawal & Safety Monograph2026-10-02Metonitazene: Complete Toxicology, Overdose, Dependence, Withdrawal & Safety Monograph2026-10-02MGM-16: Complete Evidence, Opioid Pharmacology, Dependence & Safety Monograph2026-10-02Mitragynine Pseudoindoxyl: Complete Evidence, Toxicology, Dependence, Withdrawal & Safety Monograph2026-10-02N-Desethyl Protonitazene: Metabolite, Standalone Nitazene, Toxicology & Safety Monograph2026-10-02N-Ethylhexedrone (NEH/Hexen): Complete Toxicology, Dependence & Safety Monograph2026-10-02N-Pyrrolidino Protonitazene (Protonitazepyne): Complete Toxicology, Deaths & Safety Monograph2026-10-02Nitazene Opioids: Complete Toxicology, Overdose, Dependence, Withdrawal & Safety Monograph2026-10-02O-PCE (2-Oxo-PCE): Complete Intoxication, Metabolism, Dependence & Safety Monograph2026-10-02Orphine Opioids: Complete Cychlorphine, Chlorphine, Spirochlorphine Toxicology & Safety Monograph2026-10-02Protonitazene: Complete Toxicology, Overdose, Dependence, Withdrawal & Safety Monograph2026-10-02U-47700: Complete Toxicology, Overdose, Dependence, Withdrawal & Safety Monograph2026-10-02
Supplement quality (1)
Supplement Safety (1)