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The Hippie Scientist

Evidence-first supplement research for clearer, safer decisions. Educational only — not medical advice.

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Evidence-gated safety content

Interaction Guides

Only editorially approved combinations with meaningful supporting evidence are published here. Arbitrary Safety Checker combinations remain dynamic screening results and are not turned into indexable pages.

Check a combinationScreen a stack for overlapping caution and interaction signals.Interaction guidesRead source-backed reviews for selected supplement and medication-class pairs.Understand interactionsLearn how pathway overlap, stacking, metabolism, and uncertainty affect risk.Safety checklistReview medication context, stacking, dose/form, and product-quality checks before buying.

documented · higher confidence

St. John's Wort and Hormonal Contraceptives: Interaction Evidence

Evidence-focused review of the documented interaction between St. John's wort and hormonal contraceptives, including CYP3A-related pharmacokinetic evidence.

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documented · moderate confidence

St. John's Wort and Antidepressants: Interaction Evidence

Evidence-focused review of St. John's wort with serotonergic antidepressants, separating pharmacodynamic serotonin concerns from drug-metabolism effects.

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Need a combination that is not listed? Use the interactive Safety Checker. A dynamic result is a screening aid, not an editorially verified interaction guide.