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Safety research checklist

Supplement Interaction Checklist

A non-diagnostic checklist for researching ingredient-to-ingredient and supplement-to-medication interaction signals without turning missing data into “safe.”

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Evidence-first supplement research for clearer, safer decisions. Educational only — not medical advice.

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Evidence-gated safety content

Interaction Guides

Only editorially approved combinations with meaningful supporting evidence are published here. Arbitrary Safety Checker combinations remain dynamic screening results and are not turned into indexable pages.

documented · higher confidence

St. John's Wort and Hormonal Contraceptives: Interaction Evidence

Evidence-focused review of the documented interaction between St. John's wort and hormonal contraceptives, including CYP3A-related pharmacokinetic evidence.

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documented · moderate confidence

St. John's Wort and Antidepressants: Interaction Evidence

Evidence-focused review of St. John's wort with serotonergic antidepressants, separating pharmacodynamic serotonin concerns from drug-metabolism effects.

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Need a combination that is not listed? Use the interactive Safety Checker. A dynamic result is a screening aid, not an editorially verified interaction guide.