Primary-source transparency · Living research archive
Open research investigations
See what our researchers are investigating, including null findings, contradictory trials, formulation questions and safety flags. These are research-intake notes, not independently signed-off clinical reviews. A paper appearing here does not make its conclusions approved medical guidance, an ingredient evidence grade, or a product endorsement.
- Available research rounds
- 6
- Investigation topics
- 60
- Distinct linked PMIDs in these dossiers
- 88
Linked PMIDs count unique source identifiers within the listed research documents. They may already exist elsewhere in our research ledger; they are not additional admitted studies or new canonical citations.
What is public—and what is not approved
Every available investigation title, source link, and original research note can be opened below. Editorial promotion remains separate: each claim still needs an exact PMID/DOI duplicate check, population and preparation matching, contradiction review, qualified independent scientific signoff, and publication QA. The raw research appendices are openly accessible but not indexed as consumer clinical advice.
Deep Enrichment 10
Ten investigation dossiers
DE10-01 · Research-only
St John's wort × hormonal contraception
3 original-source links in dossier · Independent review pending
DE10-02 · Research-only
Licorice and potassium-losing diuretics
2 original-source links in dossier · Independent review pending
DE10-03 · Research-only
Kelp iodine variability
2 original-source links in dossier · Independent review pending
DE10-04 · Research-only
Red yeast rice strength and contamination
2 original-source links in dossier · Independent review pending
DE10-05 · Research-only
Saw palmetto for BPH/LUTS
2 original-source links in dossier · Independent review pending
DE10-06 · Research-only
Rhodiola for depressive symptoms
1 original-source link in dossier · Independent review pending
DE10-07 · Research-only
Lion's mane cognition and population transfer
2 original-source links in dossier · Independent review pending
DE10-08 · Research-only
L-theanine stress and cognitive endpoints
2 original-source links in dossier · Independent review pending
DE10-09 · Research-only
Psyllium and LDL cholesterol
2 original-source links in dossier · Independent review pending
DE10-10 · Research-only
Cranberry prevention: contradictory RCT outcomes
3 original-source links in dossier · Independent review pending
Deep Enrichment 11
Ten investigation dossiers
DE11-01 · Research-only
Glucosamine/chondroitin for knee osteoarthritis
1 original-source link in dossier · Independent review pending
DE11-02 · Research-only
Coenzyme Q10 for statin-associated muscle symptoms
2 original-source links in dossier · Independent review pending
DE11-03 · Research-only
Selenium and vitamin E: SELECT, cancer endpoints
2 original-source links in dossier · Independent review pending
DE11-04 · Research-only
AREDS2 lutein/zeaxanthin addition versus substitution
2 original-source links in dossier · Independent review pending
DE11-05 · Research-only
Enteric/sustained-release peppermint oil for IBS
2 original-source links in dossier · Independent review pending
DE11-06 · Research-only
Bacopa monnieri memory versus instant “focus” claims
2 original-source links in dossier · Independent review pending
DE11-07 · Research-only
Tart cherry juice and insomnia
1 original-source link in dossier · Independent review pending
DE11-08 · Research-only
D-mannose for recurrent UTI: stronger trial conflicts with prior promise
2 original-source links in dossier · Independent review pending
DE11-09 · Research-only
Melatonin supplements: measured-dose and contaminant quality
2 original-source links in dossier · Independent review pending
DE11-10 · Research-only
Pyridoxine (vitamin B6) exposure and peripheral neuropathy
1 original-source link in dossier · Independent review pending
Deep Enrichment 12
Ten investigation dossiers
DE12-01 · Research-only
Butterbur: migraine benefit does not cancel pyrrolizidine-alkaloid risk
1 original-source link in dossier · Independent review pending
DE12-02 · Research-only
Feverfew: a positive replication attempt and an earlier primary null
2 original-source links in dossier · Independent review pending
DE12-03 · Research-only
American ginseng for cancer-related fatigue: primary 4-week null
1 original-source link in dossier · Independent review pending
DE12-04 · Research-only
Passionflower: preoperative anxiety versus chronic anxiety disorder
1 original-source link in dossier · Independent review pending
DE12-05 · Research-only
Alpha-lipoic acid: short-term symptom scores vs four-year progression composite
2 original-source links in dossier · Independent review pending
DE12-06 · Research-only
Aged garlic extract and blood pressure: product- and baseline-dependent
1 original-source link in dossier · Independent review pending
DE12-07 · Research-only
Green tea extract: significant ALT risk in randomized safety data
2 original-source links in dossier · Independent review pending
DE12-08 · Research-only
Beetroot dietary nitrate and hypertension: opposite controlled-trial findings
2 original-source links in dossier · Independent review pending
DE12-09 · Research-only
L-methylfolate added to SSRIs: first randomized study null
1 original-source link in dossier · Independent review pending
DE12-10 · Research-only
Oral Silexan lavender oil and GAD: branded formulation firewall
1 original-source link in dossier · Independent review pending
Deep Enrichment 13
Ten investigation dossiers
DE13-01 · Research-only
Extended-release niacin + background statin: surrogate gains are not fewer events
2 original-source links in dossier · Independent review pending
DE13-02 · Research-only
Calcium carbonate + vitamin D in the WHI: fracture endpoints vs kidney stones
2 original-source links in dossier · Independent review pending
DE13-03 · Research-only
Vitamin D-only fracture prevention in VITAL general population
1 original-source link in dossier · Independent review pending
DE13-04 · Research-only
Ginkgo biloba GEM study: dementia prevention null
1 original-source link in dossier · Independent review pending
DE13-05 · Research-only
Omega-3 fish oil for diagnosed dry-eye disease: DREAM trial
1 original-source link in dossier · Independent review pending
DE13-06 · Research-only
PLACIDE four-strain probiotics: antibiotic-associated diarrhea null
1 original-source link in dossier · Independent review pending
DE13-07 · Research-only
Echinacea angustifolia root in experimental rhinovirus challenge
1 original-source link in dossier · Independent review pending
DE13-08 · Research-only
Magnesium oxide for nocturnal leg cramps: both arms got better
1 original-source link in dossier · Independent review pending
DE13-09 · Research-only
Iron supplementation and fatigue: only for documented low-ferritin population
1 original-source link in dossier · Independent review pending
DE13-10 · Research-only
S-adenosylmethionine (SAMe): small adjunctive trial, not an OTC antidepressant equivalence study
1 original-source link in dossier · Independent review pending
Deep Enrichment 14
Ten investigation dossiers
DE14-01 · Research-only
Soluble psyllium is not interchangeable with wheat bran for IBS
1 original-source link in dossier · Independent review pending
DE14-02 · Research-only
NAC and trichotillomania: adult benefit did not replicate in children
2 original-source links in dossier · Independent review pending
DE14-03 · Research-only
Vitamin D did not prevent depression in the VITAL-DEP randomized sample
1 original-source link in dossier · Independent review pending
DE14-04 · Research-only
Curcuma longa knee pain improvement is not demonstrated structural repair
1 original-source link in dossier · Independent review pending
DE14-05 · Research-only
Garcinia cambogia: both groups lost weight, but placebo-adjusted benefit was null
1 original-source link in dossier · Independent review pending
DE14-06 · Research-only
Hibiscus tea: systolic pressure signal, not a confirmed diastolic effect
1 original-source link in dossier · Independent review pending
DE14-07 · Research-only
Saffron and depression: promising short trial, not medication equivalence
2 original-source links in dossier · Independent review pending
DE14-08 · Research-only
CoQ10 for migraine is a different efficacy question from statin-related muscle pain
1 original-source link in dossier · Independent review pending
DE14-09 · Research-only
LGG during pregnancy and infancy: early eczema result is regimen- and cohort-bound
1 original-source link in dossier · Independent review pending
DE14-10 · Research-only
Selenium: an observed diabetes-harm signal in an RCT secondary analysis
1 original-source link in dossier · Independent review pending
Deep Enrichment 15
Ten investigation dossiers
DE15-01 · Research-only
Silymarin / milk thistle cannot be presented as established hepatitis C treatment
1 original-source link in dossier · Independent review pending
DE15-02 · Research-only
L-arginine following myocardial infarction: a serious setting-specific harm signal
1 original-source link in dossier · Independent review pending
DE15-03 · Research-only
CARET beta-carotene plus vitamin A: antioxidant theory can reverse at clinical endpoints
2 original-source links in dossier · Independent review pending
DE15-04 · Research-only
Vitamin E (HOPE-TOO): surrogate antioxidant rationale did not prevent hard events
1 original-source link in dossier · Independent review pending
DE15-05 · Research-only
DHEA anti-aging: biochemical normalization does not equal restored performance
1 original-source link in dossier · Independent review pending
DE15-06 · Research-only
Evening primrose oil for eczema: not all essential-fatty-acid supplements are equivalent
1 original-source link in dossier · Independent review pending
DE15-07 · Research-only
Black cohosh: HALT trial directly measured hot flashes, not just hormone levels
1 original-source link in dossier · Independent review pending
DE15-08 · Research-only
Chromium yeast and type 2 diabetes: placebo-adjusted HbA1c is decisive
1 original-source link in dossier · Independent review pending
DE15-09 · Research-only
Soy isoflavone tablets: favorable estrogen-like theory did not prevent bone loss
1 original-source link in dossier · Independent review pending
DE15-10 · Research-only
Zinc acetate lozenges: positive and negative cold trials must be shown together
2 original-source links in dossier · Independent review pending