Compound Profile

Resveratrol

Resveratrol carries a Grade B rating — moderate evidence.

Last reviewed: June 6, 2026•5 sources citedReport a correctionProfile-wide ·B Moderate

Review needed — GI upset Details

Evidence: Moderate evidence
Typical onset: Varies by prep
Safety rating: Review needed: Safety review pending
Best for: Anti Inflammatory, Antioxidant
Avoid / review if: Anticoagulants

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Safety

Safety & Cautions

GI upset

Standard caution

Caution level: Standard. No specific caution categories were detected in the source record.

Evidence-based safety

Caution when combined

Severity and certainty are shown separately. A high-priority caution can still be theoretical: these pairings are screened from shared contraindication mechanisms and are not automatically documented clinical interactions. Provenance identifies the source fields that produced each flag; it does not upgrade the certainty of the pairwise claim.

High-Priority Caution

147 flagged pairings

Bleeding / anticoagulant risk

Representative pairings are shown below. Large mechanism groups are intentionally summarized to keep profiles focused and crawl-efficient.

Bleeding / anticoagulant riskCertainty: Theoretical

Data provenance recorded for 147 of 147 pairings in this mechanism group.

+135 more pairings share this mechanism. Use the Safety Checker to review a specific combination.

Evidence Summary

Profile-wide ·B Moderate

Evidence lens

Useful signal, but study design, dose, and population still matter.

ModerateModerate evidence

Human clinical evidence: Present in source signals

Mechanistic / preclinical: Mechanism mapped — Inflammatory Signaling Modulation · Oxidative Stress Modulation · Mitochondrial Support

Research maturity: Established research — main contexts: Anti Inflammatory · Antioxidant

Safety boundary: Safety note available — GI upset

This profile cites 5 human studies.

Evidence Strength

Confidence estimate based on the design quality and consistency of published clinical trials.

Moderate evidence

Resveratrol has a moderate evidence rating.

AdaptogenStress & MoodLongevity

Citation density

2.0

Sources

Effects

Research recency

Mixed recency

Evidence Grade

Grade B: Moderate Evidence

Evaluation of methodological rigor, population reach, and evidence alignment.

Design Match: Meta analysis
Risk of Bias: Low
Consistency: Consistent

Strongest recorded design is a meta analysis, drawn from 6 recorded studies, 6 in people. No disagreement is recorded across them.

How evidence grades work

Each grade reflects the strength and consistency of published human evidence — not marketing claims. Grades are based on study count, design quality, effect size, consistency, and recency.

Strong: Multiple RCTs, consistent direction, adequate effect size
Moderate: Some RCTs or consistent observational data in humans
Preliminary / Mixed: Animal or in-vitro only, or conflicting human data
Traditional / Theoretical: Traditional use only; no controlled human trials

Clinical Study Summaries (4)3 human evidence sources · 0 human trials · Participant totals not consistently reported · Consistency not yet classifiable

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Showing 4 of 4 studies.

What the evidence actually shows

This table contains 4 structured sources, including 3 human evidence sources; 0 are human trials.

Study	Design	N	Dose	Duration	Population	Outcome	Result & magnitude	Source
A 2026 meta-analysis of 23 randomized trials in 1,005 adults with overweight or obesity found no significant effect of resveratrol on body weight, BMI, fat mass, body-fat percentage, fat-free mass, waist-to-hip ratio, adiponectin, or leptin; waist circumference decreased modestly. Background	Meta-analysis Statistically combines results from multiple eligible studies; confidence still depends on the quality, consistency, and directness of those studies.	—	—	—	—	—	A 2026 meta-analysis of 23 randomized trials in 1,005 adults with overweight or obesity found no significant effect of resveratrol on body weight, BMI, fat mass, body-fat percentage, fat-free mass, waist-to-hip ratio, adiponectin, or leptin; waist circumference decreased modestly.	PubMed →
A seven-trial meta-analysis found no significant improvement in ApoB or ApoA-I with resveratrol. This null evidence should remain visible rather than being overshadowed by broader mechanistic or cardiometabolic claims. Background	Meta-analysis Statistically combines results from multiple eligible studies; confidence still depends on the quality, consistency, and directness of those studies.	—	—	—	—	—	A seven-trial meta-analysis found no significant improvement in ApoB or ApoA-I with resveratrol. This null evidence should remain visible rather than being overshadowed by broader mechanistic or cardiometabolic claims.	PubMed →
A 2025 meta-analysis found no significant overall effect of resveratrol on SIRT1 gene expression, SIRT1 protein expression, or serum SIRT1 levels. Some duration- or tissue-specific subgroup signals did not alter the null overall findings. Background	Meta-analysis Statistically combines results from multiple eligible studies; confidence still depends on the quality, consistency, and directness of those studies.	—	—	—	—	—	A 2025 meta-analysis found no significant overall effect of resveratrol on SIRT1 gene expression, SIRT1 protein expression, or serum SIRT1 levels. Some duration- or tissue-specific subgroup signals did not alter the null overall findings.	PubMed →
Synthesis of hyperbranched polyethylene amphiphiles by chain walking polymerization in tandem with RAFT polymerization and supramolecular self-assembly vesicles Background	Other / unclear The study design is not yet classified clearly enough to infer its place in the evidence hierarchy.	—	—	—	—	—	Synthesis of hyperbranched polyethylene amphiphiles by chain walking polymerization in tandem with RAFT polymerization and supramolecular self-assembly vesicles	PubMed →

How Resveratrol Works

Simplified mechanism pathway based on preclinical and pharmacological evidence. Does not confirm clinical efficacy.

Mechanism Pathway — How Resveratrol Works

CompoundTarget / ReceptorMechanismEffect / Outcome

Dosing

Dose guidance: 150 500 mg/day

Mechanisms & biological pathways

Preclinical mechanism details from scientific profiles; these represent plausible pathways but do not guarantee clinical efficacy in humans.

Inflammatory Signaling Modulation
Oxidative Stress Modulation
Mitochondrial Support
Metabolic Regulation
Vascular Function Support
SIRT1 Signaling

Botanical Context

Source botanicals and comparison guides related to Resveratrol.

Found in

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Compare & Sourcing

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Sourcing options

Resveratrol product picks

Recommendation status

Product recommendations are not shown for this profile because the current site safety and monetization policy does not permit them.

Product form & quality guidelines

When sourcing Resveratrol, verify the label for:

Standardized Extract: Confirm active content percentages on the supplement facts panel (e.g. standardized to specific marker compounds) rather than simple raw herb weights.
Third-Party Testing: Look for independent purity labels (USP, NSF, ConsumerLab, or Eurofins) to ensure the product is free from heavy metals, solvents, and contaminants.
Form Bioavailability: Ensure the form matches evidence-supported configurations (e.g. chelated bisglycinate/glycinate for magnesium, micronized monohydrate for creatine) for optimal onset and digestion tolerance.

Safety first · Harm reduction

This information is educational and not medical advice. Start low, avoid risky combinations, and consult a licensed clinician before making health decisions—especially if you use medications, have diagnosed conditions, or are pregnant/breastfeeding.

Learn how we evaluate confidence, safety, and intensity on the methodology page.

By Willie B. Randolph III

Founder & Head Researcher · Oak Ridge, TN · Last reviewed August 2026

Editorial Review

Checked against primary sources, cited evidence, and contraindication language before publication. Evidence claims, safety language, and affiliate modules are reviewed independently. Not personal medical advice.

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