Compound Profile
Trazodone
Compound profile with evidence, safety, and practical fit.
Safety context — U. Details
- Evidence
- Limited evidence
- Typical onset
- Varies by prep
- Safety rating
- Safety context: Use caution
- Best for
- Serotonergic Signaling, Serotonin Reuptake Inhibition And Receptor Antagonism
Safety
Safety & Cautions
U. S.
High caution
Caution level: High. Multiple caution categories apply, or the record uses avoid/contraindication language.
- Interaction-AwareMedication or interaction context is explicitly noted.
- Stimulant-Like ProfileStimulant-like or activating caution language is present.
- Anticoagulant CautionBleeding or anticoagulant-adjacent caution language is present.
Evidence Summary
Profile-wide ·C LimitedEvidence lens
Read as directional context, not settled clinical proof.
Human clinical evidence: Present in source signals
Mechanistic / preclinical: Mechanism mapped
Research maturity: Emerging research — main contexts: Serotonergic Signaling · Serotonin Reuptake Inhibition And Receptor Antagonism
Safety boundary: Safety note available — U.
Confidence estimate based on the design quality and consistency of published clinical trials.
Trazodone has a limited evidence rating.
Grade C: Limited Evidence
Evaluation of methodological rigor, population reach, and evidence alignment.
- Design Match
- Meta analysis
- Risk of Bias
- Low
- Consistency
- Consistent
How evidence grades work
Each grade reflects the strength and consistency of published human evidence — not marketing claims. Grades are based on study count, design quality, effect size, consistency, and recency.
- Strong
- Multiple RCTs, consistent direction, adequate effect size
- Moderate
- Some RCTs or consistent observational data in humans
- Preliminary / Mixed
- Animal or in-vitro only, or conflicting human data
- Traditional / Theoretical
- Traditional use only; no controlled human trials
Clinical Study Summaries (4)3 human evidence sources · 0 human trials · Participant totals not consistently reported · Consistency not yet classifiable
Filter by study class
Showing 4 of 4 studies.
What the evidence actually shows
This table contains 4 structured sources, including 3 human evidence sources; 0 are human trials.
| Study | Design | N | Dose | Duration | Population | Outcome | Result & magnitude | Source |
|---|---|---|---|---|---|---|---|---|
Background | Meta-analysis Statistically combines results from multiple eligible studies; confidence still depends on the quality, consistency, and directness of those studies. | — | — | — | — | — | A 2018 network meta-analysis of 522 randomized trials involving 116,477 adults included trazodone among 21 antidepressants and found all included antidepressants more efficacious than placebo for acute major depressive disorder, with comparative estimates varying across treatments and evidence certainty. | PubMed → |
Background | Meta-analysis Statistically combines results from multiple eligible studies; confidence still depends on the quality, consistency, and directness of those studies. | — | — | — | — | — | A 2026 systematic review and meta-analysis of 10 randomized trials involving 1,029 participants with depressive disorders and sleep problems reported pooled improvement in sleep-quality and depressive outcomes with trazodone, while somnolence and sedation were more frequent. | PubMed → |
Background | Systematic review Uses a predefined method to find and evaluate relevant studies, but may or may not pool their results statistically. | — | — | — | — | — | A 2017 systematic review summarized 45 studies of trazodone for insomnia or sleep outcomes and described evidence of sleep benefit across heterogeneous designs, while also noting drowsiness as a common adverse effect. | PubMed → |
Background | Other / unclear The study design is not yet classified clearly enough to infer its place in the evidence hierarchy. | — | — | — | — | — | A 2026 U.S. DailyMed label identifies trazodone hydrochloride tablets for treatment of major depressive disorder in adults and carries a boxed warning about suicidal thoughts and behaviors in pediatric and young adult patients. | Source → |
Dosing
- No standardized dose
- No standardized dose is established for this ingredient in our source data. Preparations differ widely, so follow the standardization on the product you actually have and speak to a clinician before starting.
Botanical Context
Source botanicals and comparison guides related to Trazodone.
Compare & Sourcing
Compare side-by-side tradeoffs or verify active marker guidelines.
Review available sources for Trazodone
Independent database mapping — evaluated separately from safety and efficacy scores.
Affiliate disclosure: Shopping links may earn this site a commission at no cost to you. Links are chosen on quality and availability, never commission tiers; safety warnings and evidence ratings stay independent.
Safety first · Harm reduction
This information is educational and not medical advice. Start low, avoid risky combinations, and consult a licensed clinician before making health decisions—especially if you use medications, have diagnosed conditions, or are pregnant/breastfeeding.
Learn how we evaluate confidence, safety, and intensity on the methodology page.
Founder & Head Researcher · Oak Ridge, TN · Last reviewed August 2026
Editorial Review
Checked against primary sources, cited evidence, and contraindication language before publication. Evidence claims, safety language, and affiliate modules are reviewed independently. Not personal medical advice.
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