Compound Profile
Atractylenolide III
Sesquiterpene lactone from Atractylodes with cytoprotective and immune modulating properties.
Last reviewed: •1 human studies cited
C PreliminaryMonograph visual
Atractylenolide III
Generated profile category visual
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Quick Stats
Evidence level
Limited evidence
Typical onset
Varies by prep
Safety rating
Use extra caution: Interaction risk
Best for
NF κB, PI3K/Akt
Found In
Botanicals that contain Atractylenolide III, with full herb profiles.
Safety & Cautions
Safety evidence
review-level evidence is primarily in vitro and animal-based
Who should avoid this?
No specific evidence-backed contraindication is documented for this profile. This is not the same as established safety.
Possible metabolic-enzyme inhibition is a research concern, not an established clinical interaction; human dose-response, pregnancy, breastfeeding, liver, kidney, surgery, and medication-interaction safety remain insufficient.
Talk to a healthcare professional if: you use relevant medications, you are pregnant or breastfeeding, surgery is planned or recent, you have a condition named in this safety summary.
Evidence Summary
C PreliminaryEvidence lens
Early signal that needs stronger human replication before practical claims.
PreliminaryLimited evidence
Human clinical evidence: Present in source signals
Mechanistic / preclinical: Mechanism mapped — Inflammatory Signaling Modulation · Cellular Protection · Immune Signaling Modulation
Research maturity: Preliminary or mixed — main contexts: NF κB · PI3K/Akt
Safety boundary: Safety note available — Review medications, pregnancy status, chronic conditions, and clinician guidance before use.
This profile cites 1 human study.
Evidence Strength
Confidence estimate based on the design quality and consistency of published clinical trials.
Atractylenolide III has a limited evidence evidence rating.
General wellnessGeneral wellness
Citation density
0.5
Sources
1
Effects
2
Research recency
Mixed recency
How evidence grades work
Each grade reflects the strength and consistency of published human evidence — not marketing claims. Grades are based on study count, design quality, effect size, consistency, and recency.
A
Strong
Multiple RCTs, consistent direction, adequate effect size
B
Moderate
Some RCTs or consistent observational data in humans
C
Preliminary / Mixed
Animal or in-vitro only, or conflicting human data
D
Traditional / Theoretical
Traditional use only; no controlled human trials
Clinical Study Summaries (1)Cited studies informing this profile. RCTs and reviews shown first.
How Atractylenolide III Works
Simplified mechanism pathway based on preclinical and pharmacological evidence. Does not confirm clinical efficacy.
Mechanism Pathway — How Atractylenolide III Works
CompoundTarget / ReceptorMechanismEffect / Outcome
Mechanisms & Biological Pathways▼
Preclinical mechanism details from scientific profiles; these represent plausible pathways but do not guarantee clinical efficacy in humans.
Inflammatory Signaling ModulationCellular ProtectionImmune Signaling ModulationNF KB ModulationInflammatory
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Compare & Sourcing
Compare side-by-side tradeoffs or verify active marker guidelines.
Review available sources for Atractylenolide III
Independent database mapping — evaluated separately from safety and efficacy scores.
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Related alternatives
Herbs for similar conditions
Tradeoffs
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Safety first · Harm reduction
This information is educational and not medical advice. Start low, avoid risky combinations, and consult a licensed clinician before making health decisions—especially if you use medications, have diagnosed conditions, or are pregnant/breastfeeding.
Learn how we evaluate confidence, safety, and intensity on the methodology page.
Editorial Review
Checked against primary sources, cited evidence, and contraindication language before publication. Evidence claims, safety language, and affiliate modules are reviewed independently. Not personal medical advice.
Compound profile context
How to interpret Atractylenolide III
Atractylenolide III dosage by use case, onset and duration, safety limits, and interactions for nf κb, graded against research. Limited Human Evidence… Use this compound profile to understand mechanism, evidence quality, and practical safety context before comparing products or building a stack. A biochemical pathway connection can be useful for discovery, but it is not the same as proven benefit in humans.
When reviewing Atractylenolide III, separate the active molecule from the product category around it. Dose form, absorption, extract standardization, medication interactions, and individual sensitivity can change the real-world risk-benefit picture.
For supplement planning, avoid combining multiple compounds with overlapping sedating, stimulating, serotonergic, blood-pressure, anticoagulant, or liver-metabolism effects unless a qualified clinician has reviewed the context.