Related Compounds
Compounds connected by the same goals, effects, or research topics.
Compound Profile
Horsetail
Horsetail is a silica containing botanical with insufficient human clinical evidence and safety concerns with prolonged use.
Use extra caution — Contains thiaminase; possible vitamin B1 depletion; avoid prolonged unsupervised use. Details
Last reviewed: Report a correctionProfile-wide ·C Limited
At a glance
From this profile's structured data- Evidence
- Grade C
- Safety
- Contains thiaminase; possible vitamin B1 depletion; avoid prolonged unsupervised use.
- Profile context
- connective tissue, urinary tract (traditional)
Quick stats
- Evidence level
- Limited evidence
- Typical onset
- Varies by prep
- Safety rating
- Use extra caution: Use caution
- Best for
- Connective Tissue, Urinary Tract (Traditional)
Safety
Safety & Cautions
Contains thiaminase; possible vitamin B1 depletion; avoid prolonged unsupervised use.
High caution
Caution level: High. Multiple caution categories apply, or the record uses avoid/contraindication language.
Evidence Summary
Profile-wide ·C LimitedEvidence lens
Read as directional context, not settled clinical proof.
LimitedLimited evidence
Human clinical evidence: Not the primary signal
Mechanistic / preclinical: Mechanism mapped — Collagen Synthesis Pathway Support · Diuretic/Urinary Tract Effect · Flavonoid Related Effects
Research maturity: Theoretical / mechanistic research — Mechanistic or unresolved evidence is kept separate from established human outcomes.
Safety boundary: Safety note available — Contains thiaminase; possible vitamin B1 depletion; avoid prolonged unsupervised use.
Evidence Strength
Confidence estimate based on the design quality and consistency of published clinical trials.
Horsetail has a limited evidence rating.
Inflammation SupportLongevity
Effects
2
How evidence grades work
Each grade reflects the strength and consistency of published human evidence — not marketing claims. Grades are based on study count, design quality, effect size, consistency, and recency.
- Strong
- Multiple RCTs, consistent direction, adequate effect size
- Moderate
- Some RCTs or consistent observational data in humans
- Preliminary / Mixed
- Animal or in-vitro only, or conflicting human data
- Traditional / Theoretical
- Traditional use only; no controlled human trials
How Horsetail Works
Simplified mechanism pathway based on preclinical and pharmacological evidence. Does not confirm clinical efficacy.
Mechanism Pathway — How Horsetail Works
CompoundTarget / ReceptorMechanismEffect / Outcome
Dosing
- Common form
- standardized extract capsule
- No standardized dose
- Our source data records the usual product form for this ingredient but no studied dose. Preparations differ widely, so follow the standardization on the product you actually have and speak to a clinician before starting.
Mechanisms & biological pathways
Preclinical mechanism details from scientific profiles; these represent plausible pathways but do not guarantee clinical efficacy in humans.
- Collagen Synthesis Pathway Support
- Diuretic/Urinary Tract Effect
- Flavonoid Related Effects
- Antioxidant Enzyme Induction
- Silica Provision
Continue exploring
Related research paths
Related Herbs
Botanicals connected by the same goals, effects, or research topics.
Related Safety Pages
Safety checks and cautions relevant to this decision.
Related Guides
Deeper context, comparisons, and practical research paths.
Related Articles
Deeper context, comparisons, and practical research paths.
Compare & Sourcing
Compare side-by-side tradeoffs or verify active marker guidelines.
Free safety checklist
Get the Horsetail evidence notes
Occasional research updates, safety context, and product-quality checks for supplement decisions.
We use your email to send the checklist and occasional evidence-first supplement updates. Unsubscribe anytime. Privacy policy.
Safety first · Harm reduction
This information is educational and not medical advice. Start low, avoid risky combinations, and consult a licensed clinician before making health decisions—especially if you use medications, have diagnosed conditions, or are pregnant/breastfeeding.
Learn how we evaluate confidence, safety, and intensity on the methodology page.
Editorial Review
Checked against primary sources, cited evidence, and contraindication language before publication. Evidence claims, safety language, and affiliate modules are reviewed independently. Not personal medical advice.
Help improve this profile
Was this useful for your research?
These controls record only the page and the structured choice you make when analytics consent is enabled. Please don’t include personal medical information in research requests.
Was this evidence summary clear?
Did you find what you were researching?