Compound Profile
Indirubin
Bis indole alkaloid pigment known from indigo yielding plants and studied for kinase targeted activity.
Last reviewed: Report a correctionProfile-wide ·C Limited
Use extra caution — Isolated alkaloid exposure may affect CYP/P gp handling, glucose, blood pressure, and GI tolerance; avoid pregnancy/breastfeeding unless clinician directed. Details
- Evidence
- Limited evidence
- Typical onset
- Varies by prep
- Safety rating
- Use extra caution: Use caution
- Best for
- STAT3
- Avoid / review if
- Pregnancy
Safety
Safety & Cautions
Isolated alkaloid exposure may affect CYP/P gp handling, glucose, blood pressure, and GI tolerance; avoid pregnancy/breastfeeding unless clinician directed.
High caution
Caution level: High. Multiple caution categories apply, or the record uses avoid/contraindication language.
- Pregnancy/Breastfeeding CautionPregnancy or breastfeeding caution language is present.
Evidence Summary
Profile-wide ·C LimitedEvidence lens
Read as directional context, not settled clinical proof.
LimitedLimited evidence
Human clinical evidence: Not the primary signal
Mechanistic / preclinical: Mechanism mapped — Cyclin Dependent Kinase Modulation · GSK 3 Inhibition · Kinase Inhibition
Research maturity: Theoretical / mechanistic research — Mechanistic or unresolved evidence is kept separate from established human outcomes.
Safety boundary: Safety note available — Isolated alkaloid exposure may affect CYP/P gp handling, glucose, blood pressure, and GI tolerance; avoid pregnancy/breastfeeding unless clinician directed.
Evidence Strength
Confidence estimate based on the design quality and consistency of published clinical trials.
Indirubin has a limited evidence rating.
General wellnessGeneral wellness
Effects
1
How evidence grades work
Each grade reflects the strength and consistency of published human evidence — not marketing claims. Grades are based on study count, design quality, effect size, consistency, and recency.
- Strong
- Multiple RCTs, consistent direction, adequate effect size
- Moderate
- Some RCTs or consistent observational data in humans
- Preliminary / Mixed
- Animal or in-vitro only, or conflicting human data
- Traditional / Theoretical
- Traditional use only; no controlled human trials
How Indirubin Works
Simplified mechanism pathway based on preclinical and pharmacological evidence. Does not confirm clinical efficacy.
Mechanism Pathway — How Indirubin Works
CompoundTarget / ReceptorMechanismEffect / Outcome
Dosing
- Common form
- capsule or standardized extract
- No standardized dose
- Our source data records the usual product form for this ingredient but no studied dose. Preparations differ widely, so follow the standardization on the product you actually have and speak to a clinician before starting.
Mechanisms & biological pathways
Preclinical mechanism details from scientific profiles; these represent plausible pathways but do not guarantee clinical efficacy in humans.
- Cyclin Dependent Kinase Modulation
- GSK 3 Inhibition
- Kinase Inhibition
- Cell Cycle Regulation
- Vascular Function Support
Botanical Context
Source botanicals and comparison guides related to Indirubin.
Compare active botanicals
Compare & Sourcing
Compare side-by-side tradeoffs or verify active marker guidelines.
Safety first · Harm reduction
This information is educational and not medical advice. Start low, avoid risky combinations, and consult a licensed clinician before making health decisions—especially if you use medications, have diagnosed conditions, or are pregnant/breastfeeding.
Learn how we evaluate confidence, safety, and intensity on the methodology page.
Founder & Head Researcher · Oak Ridge, TN · Last reviewed August 2026
Editorial Review
Checked against primary sources, cited evidence, and contraindication language before publication. Evidence claims, safety language, and affiliate modules are reviewed independently. Not personal medical advice.
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