Related Compounds
Compounds connected by the same goals, effects, or research topics.
Compound Profile
Red Yeast Rice
Statin like supplement comparison; safety screen: statins; liver disease; pregnancy; CYP3A4 inhibitors.
Use extra caution — Acts like a statin when monacolin K is present; liver/muscle and drug interaction flags are central. Details
Last reviewed: •1 source citedReport a correctionProfile-wide ·D Preliminary
At a glance
From this profile's structured data- Evidence
- Grade D
- Safety
- Acts like a statin when monacolin K is present; liver/muscle and drug-interaction flags are central.
- Profile context
- HMG-CoA reductase
Next stepsWhere to go next — guides & comparisons
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Quick stats
- Evidence level
- Preliminary evidence
- Typical onset
- Varies by prep
- Safety rating
- Use extra caution: Interaction risk
- Best for
- HMG CoA Reductase
- Avoid / review if
- Liver
Safety
Safety & Cautions
Acts like a statin when monacolin K is present; liver/muscle and drug interaction flags are central.
High caution
Caution level: High. Multiple caution categories apply, or the record uses avoid/contraindication language.
- Interaction-AwareMedication or interaction context is explicitly noted.
- Liver-SensitiveLiver-related caution language appears in the profile.
Evidence Summary
Profile-wide ·D PreliminaryEvidence lens
Early signal that needs stronger human replication before practical claims.
PreliminaryPreliminary evidence
Human clinical evidence: Not the primary signal
Mechanistic / preclinical: Mechanism mapped — Metabolic Regulation · Vascular Function Support · Lipid Metabolism Support
Research maturity: Theoretical / mechanistic research — Mechanistic or unresolved evidence is kept separate from established human outcomes.
Safety boundary: Safety note available — Acts like a statin when monacolin K is present; liver/muscle and drug interaction flags are central.
This profile cites 1 human study.
Evidence Strength
Confidence estimate based on the design quality and consistency of published clinical trials.
Red Yeast Rice has a preliminary evidence rating.
General wellnessGeneral wellness
Citation density
1.0
Sources
1
Effects
1
Research recency
Mixed recency
Evidence Grade
Grade D: Preliminary / Theoretical Evidence
Evaluation of methodological rigor, population reach, and evidence alignment.
- Design Match
- Regulatory or official guidance
- Risk of Bias
- High
- Consistency
- Not assessed
Strongest recorded design is a regulatory or official guidance, drawn from 1 recorded study, none of which measured an outcome in people.
How evidence grades work
Each grade reflects the strength and consistency of published human evidence — not marketing claims. Grades are based on study count, design quality, effect size, consistency, and recency.
- Strong
- Multiple RCTs, consistent direction, adequate effect size
- Moderate
- Some RCTs or consistent observational data in humans
- Preliminary / Mixed
- Animal or in-vitro only, or conflicting human data
- Traditional / Theoretical
- Traditional use only; no controlled human trials
Clinical Study Summaries (1)0 human evidence sources · 0 human trials · Participant totals not consistently reported · Consistency not yet classifiable
What the evidence actually shows
This table contains 1 structured source, including 0 human evidence sources; 0 are human trials. A reliable participant total cannot be calculated because sample size is not consistently structured in the cited sources. Source-to-conclusion relationships are not classified in this structured set, so consistency is not yet classifiable.
Profile-wide evidence grade: see the profile grade above · Confidence: not separately assigned
What would change our conclusion?
Larger, well-controlled human trials using comparable populations, doses, preparations, and clinically meaningful outcomes could materially strengthen or weaken this conclusion. Replication in a different population or a high-quality synthesis resolving current disagreement could also materially change confidence.
| Study | Design | N | Dose | Duration | Population | Outcome | Result & magnitude | Source |
|---|---|---|---|---|---|---|---|---|
PubMed · Blood Cells Mol Dis · 2016 Background | Other / unclear The study design is not yet classified clearly enough to infer its place in the evidence hierarchy. | — | — | — | — | — | — | PubMed → |
How Red Yeast Rice Works
Simplified mechanism pathway based on preclinical and pharmacological evidence. Does not confirm clinical efficacy.
Mechanism Pathway — How Red Yeast Rice Works
CompoundTarget / ReceptorMechanismEffect / Outcome
Dosing
- No standardized dose
- No standardized dose is established for this ingredient in our source data. Preparations differ widely, so follow the standardization on the product you actually have and speak to a clinician before starting.
Mechanisms & biological pathways
Preclinical mechanism details from scientific profiles; these represent plausible pathways but do not guarantee clinical efficacy in humans.
- Metabolic Regulation
- Vascular Function Support
- Lipid Metabolism Support
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Safety first · Harm reduction
This information is educational and not medical advice. Start low, avoid risky combinations, and consult a licensed clinician before making health decisions—especially if you use medications, have diagnosed conditions, or are pregnant/breastfeeding.
Learn how we evaluate confidence, safety, and intensity on the methodology page.
Editorial Review
Checked against primary sources, cited evidence, and contraindication language before publication. Evidence claims, safety language, and affiliate modules are reviewed independently. Not personal medical advice.
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Compound profile context
How to interpret Red Yeast Rice
Red Yeast Rice compound profile with evidence context, key research topics, source notes, safety context, and references presented in an evidence-first… Use this compound profile to understand mechanism, evidence quality, and practical safety context before comparing products or building a stack. A biochemical pathway connection can be useful for discovery, but it is not the same as proven benefit in humans.
When reviewing Red Yeast Rice, separate the active molecule from the product category around it. Dose form, absorption, extract standardization, medication interactions, and individual sensitivity can change the real-world risk-benefit picture.
For supplement planning, avoid combining multiple compounds with overlapping sedating, stimulating, serotonergic, blood-pressure, anticoagulant, or liver-metabolism effects unless a qualified clinician has reviewed the context.