Compound Profile
Saccharomyces Boulardii
Traveler’s diarrhea context; gut resilience; safety screen: central venous catheter; severe immunocompromise; critical illness.
Last reviewed: •2 sources citedReport a correctionProfile-wide ·B Moderate
Use extra caution — Fungemia risk is rare but important in central line or severe immunocompromise contexts. Details
- Evidence
- Moderate evidence
- Typical onset
- Varies by prep
- Safety rating
- Use extra caution: Use caution
- Best for
- Intestinal Pathogens, Gut Immune Response
Safety
Safety & Cautions
Fungemia risk is rare but important in central line or severe immunocompromise contexts.
Standard caution
Caution level: Standard. No specific caution categories were detected in the source record.
Evidence Summary
Profile-wide ·B ModerateEvidence lens
Useful signal, but study design, dose, and population still matter.
ModerateModerate evidence
Human clinical evidence: Present in source signals
Mechanistic / preclinical: Mechanism mapped — Immune Signaling Modulation · Gut Microbiome · Liver Detoxification
Research maturity: Established research — main contexts: Intestinal Pathogens · Gut Immune Response
Safety boundary: Safety note available — Fungemia risk is rare but important in central line or severe immunocompromise contexts.
This profile cites 2 human studies.
Evidence Strength
Confidence estimate based on the design quality and consistency of published clinical trials.
Saccharomyces Boulardii has a moderate evidence rating.
General wellnessGeneral wellness
Citation density
1.0
Sources
2
Effects
2
Research recency
Mixed recency
Evidence Grade
Grade B: Moderate Evidence
Evaluation of methodological rigor, population reach, and evidence alignment.
- Design Match
- Meta analysis
- Risk of Bias
- Low
- Consistency
- Consistent
Strongest recorded design is a meta analysis, drawn from 3 recorded studies, 3 in people. No disagreement is recorded across them.
How evidence grades work
Each grade reflects the strength and consistency of published human evidence — not marketing claims. Grades are based on study count, design quality, effect size, consistency, and recency.
- Strong
- Multiple RCTs, consistent direction, adequate effect size
- Moderate
- Some RCTs or consistent observational data in humans
- Preliminary / Mixed
- Animal or in-vitro only, or conflicting human data
- Traditional / Theoretical
- Traditional use only; no controlled human trials
Clinical Study Summaries (2)2 human evidence sources · 0 human trials · Participant totals not consistently reported · Consistency not yet classifiable
What the evidence actually shows
This table contains 2 structured sources, including 2 human evidence sources; 0 are human trials.
| Study | Design | N | Dose | Duration | Population | Outcome | Result & magnitude | Source |
|---|---|---|---|---|---|---|---|---|
Systematic review and meta-analysis of Saccharomyces boulardii in adult patients PubMed · World J Gastroenterol · 2010 Background | Meta-analysis Statistically combines results from multiple eligible studies; confidence still depends on the quality, consistency, and directness of those studies. | — | — | — | — | — | — | PubMed → |
Background | Meta-analysis Statistically combines results from multiple eligible studies; confidence still depends on the quality, consistency, and directness of those studies. | — | — | — | — | — | — | Source → |
How Saccharomyces Boulardii Works
Simplified mechanism pathway based on preclinical and pharmacological evidence. Does not confirm clinical efficacy.
Mechanism Pathway — How Saccharomyces Boulardii Works
CompoundTarget / ReceptorMechanismEffect / Outcome
Dosing
- Common form
- powder or capsule
- No standardized dose
- Our source data records the usual product form for this ingredient but no studied dose. Preparations differ widely, so follow the standardization on the product you actually have and speak to a clinician before starting.
Mechanisms & biological pathways
Preclinical mechanism details from scientific profiles; these represent plausible pathways but do not guarantee clinical efficacy in humans.
- Immune Signaling Modulation
- Gut Microbiome
- Liver Detoxification
- Immune Modulation
Compare & Sourcing
Compare side-by-side tradeoffs or verify active marker guidelines.
Sourcing options disabled for safety
Direct product recommendations and affiliate links are suppressed for this compound due to its high caution or needs-review safety classification.
Evaluate the safety checks, contraindications, and potential medication interactions above under clinician supervision before use.
Safety first · Harm reduction
This information is educational and not medical advice. Start low, avoid risky combinations, and consult a licensed clinician before making health decisions—especially if you use medications, have diagnosed conditions, or are pregnant/breastfeeding.
Learn how we evaluate confidence, safety, and intensity on the methodology page.
Founder & Head Researcher · Oak Ridge, TN · Last reviewed August 2026
Editorial Review
Checked against primary sources, cited evidence, and contraindication language before publication. Evidence claims, safety language, and affiliate modules are reviewed independently. Not personal medical advice.
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