Compound Profile

Yohimbine

Yohimbine carries a Grade B rating — moderate evidence.

Last reviewed: •1 source citedReport a correctionProfile-wide ·B Moderate

Review needed — Can cause hypertension, anxiety, tachycardia; contraindicated in cardiovascular disease. Details

Evidence
Moderate evidence
Typical onset
Varies by prep
Safety rating
Review needed: Safety review pending
Best for
Alpha 2 Adrenergic Receptor
Avoid / review if
Monoamine Oxidase Inhibitor Medications Due To Hypertensive Crisis Risk, Hypertension Or Other Cardiovascular Disease Including Recent Heart Attack Or Arrhythmia, Severe Kidney Or Liver Disease Reduces Clearance
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Yohimbine monograph visual
Generated profile category visual

Safety

Safety & Cautions

Can cause hypertension, anxiety, tachycardia; contraindicated in cardiovascular disease.

High caution

Caution level: High. Multiple caution categories apply, or the record uses avoid/contraindication language.

  • Liver-SensitiveLiver-related caution language appears in the profile.
  • Stimulant-Like ProfileStimulant-like or activating caution language is present.

Evidence-based safety

Caution when combined

Severity and certainty are shown separately. A high-priority caution can still be theoretical: these pairings are screened from shared contraindication mechanisms and are not automatically documented clinical interactions. Provenance identifies the source fields that produced each flag; it does not upgrade the certainty of the pairwise claim.

High-Priority Caution

26 flagged pairings

Serotonergic activity

Representative pairings are shown below. Large mechanism groups are intentionally summarized to keep profiles focused and crawl-efficient.

Serotonergic activityCertainty: Theoretical

Data provenance recorded for 26 of 26 pairings in this mechanism group.

+14 more pairings share this mechanism. Use the Safety Checker to review a specific combination.

Moderate Caution

81 flagged pairings

Blood-pressure effects

Representative pairings are shown below. Large mechanism groups are intentionally summarized to keep profiles focused and crawl-efficient.

Blood-pressure effectsCertainty: Theoretical

Data provenance recorded for 81 of 81 pairings in this mechanism group.

+69 more pairings share this mechanism. Use the Safety Checker to review a specific combination.

Evidence Summary

Profile-wide ·B Moderate

Evidence lens

Useful signal, but study design, dose, and population still matter.

ModerateModerate evidence

Human clinical evidence: Not the primary signal

Mechanistic / preclinical: Mechanism mapped — Metabolic Regulation · Vascular Function Support · Adrenergic

Research maturity: Theoretical / mechanistic research — Mechanistic or unresolved evidence is kept separate from established human outcomes.

Safety boundary: Safety note available — Can cause hypertension, anxiety, tachycardia; contraindicated in cardiovascular disease.

This profile cites 1 human study.

Evidence Strength

Confidence estimate based on the design quality and consistency of published clinical trials.

Moderate evidence

Yohimbine has a moderate evidence rating.

General wellnessGeneral wellness
Citation density
1.0
Sources
1
Effects
1
Research recency
Mixed recency
Evidence Grade

Grade B: Moderate Evidence

Evaluation of methodological rigor, population reach, and evidence alignment.

Design Match
Meta analysis
Risk of Bias
Low
Consistency
Not assessed
Strongest recorded design is a meta analysis, drawn from 1 recorded study, 1 in people.
How evidence grades work

Each grade reflects the strength and consistency of published human evidence — not marketing claims. Grades are based on study count, design quality, effect size, consistency, and recency.

Strong
Multiple RCTs, consistent direction, adequate effect size
Moderate
Some RCTs or consistent observational data in humans
Preliminary / Mixed
Animal or in-vitro only, or conflicting human data
Traditional / Theoretical
Traditional use only; no controlled human trials
Clinical Study Summaries (1)0 human evidence sources · 0 human trials · Participant totals not consistently reported · Consistency not yet classifiable

What the evidence actually shows

This table contains 1 structured source, including 0 human evidence sources; 0 are human trials.

StudyDesignNDoseDurationPopulationOutcomeResult & magnitudeSource

Yohimbine as a treatment for erectile dysfunction: A systematic review and meta-analysis

PubMed · Turk J Urol · 2021

Background
Other / unclear

The study design is not yet classified clearly enough to infer its place in the evidence hierarchy.

——————PubMed →

How Yohimbine Works

Simplified mechanism pathway based on preclinical and pharmacological evidence. Does not confirm clinical efficacy.

Mechanism Pathway — How Yohimbine Works

How Yohimbine WorksYohimbine acts on biological target pathways via metabolic (regulation), leading to alpha 2 adrenergic receptor.YohimbineBiological TargetBiological pathwayMetabolicRegulationAlpha 2 Adrenergic ReceptorObservable outcomeVascular FunctionSupport
CompoundTarget / ReceptorMechanismEffect / Outcome

Dosing

Common form
capsule
No standardized dose
Our source data records the usual product form for this ingredient but no studied dose. Preparations differ widely, so follow the standardization on the product you actually have and speak to a clinician before starting.
Mechanisms & biological pathways

Preclinical mechanism details from scientific profiles; these represent plausible pathways but do not guarantee clinical efficacy in humans.

  • Metabolic Regulation
  • Vascular Function Support
  • Adrenergic
  • Metabolic

Botanical Context

Source botanicals and comparison guides related to Yohimbine.

Compare active botanicals

Compare & Sourcing

Compare side-by-side tradeoffs or verify active marker guidelines.

Safety first · Harm reduction

This information is educational and not medical advice. Start low, avoid risky combinations, and consult a licensed clinician before making health decisions—especially if you use medications, have diagnosed conditions, or are pregnant/breastfeeding.

Learn how we evaluate confidence, safety, and intensity on the methodology page.

By Willie B. Randolph III

Founder & Head Researcher · Oak Ridge, TN · Last reviewed August 2026

Editorial Review

Checked against primary sources, cited evidence, and contraindication language before publication. Evidence claims, safety language, and affiliate modules are reviewed independently. Not personal medical advice.

Editorial Standards →

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