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Herb Profile
Cissus
Cissus quadrangularis
Cissus (Cissus quadrangularis) carries a Grade C rating — limited evidence.
Last reviewed: •3 sources citedReport a correctionProfile-wide ·C Limited
Use extra caution — May influence glucose or metabolic markers; monitor with antidiabetic medications and avoid pregnancy/breastfeeding use unless clinician supervised. Details
- Evidence
- Limited Evidence
- Typical onset
- Varies by prep
- Safety rating
- High caution
- Best for
- Anti Inflammatory, Analgesic, Inflammatory signaling, Metabolic health
- Avoid / review if
- Pregnancy/Breastfeeding Without Clinician Guidance, Diabetes Medications Without Monitoring, May Potentiate Antidiabetic Agents
At a glance
From this profile's structured data- Evidence
- Grade C
- Safety
- May influence glucose or metabolic markers; monitor with antidiabetic medications and avoid pregnancy/breastfeeding use unless clinician-supervised.
- Profile context
- anti-inflammatory, analgesic
Next stepsWhere to go next — guides & comparisons
Continue reading
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Safety
Safety & Cautions
May influence glucose or metabolic markers; monitor with antidiabetic medications and avoid pregnancy/breastfeeding use unless clinician supervised.
High caution
Caution level: High. Multiple caution categories apply, or the record uses avoid/contraindication language.
- Pregnancy/Breastfeeding CautionPregnancy or breastfeeding caution language is present.
Detailed safety fields
Pregnancy, breastfeeding, and contraindications
- Pregnancy/Breastfeeding Without Clinician Guidance
- Diabetes Medications Without Monitoring
- May Potentiate Antidiabetic Agents
- Caution With Anticoagulants If Blended Products Include Additional Actives.
Safety classifications
- Pregnancy/Breastfeeding Caution: Pregnancy or breastfeeding caution language is present.
Full safety note
- May influence glucose or metabolic markers; monitor with antidiabetic medications and avoid pregnancy/breastfeeding use unless clinician supervised.
Safety labels
- Pregnancy/Breastfeeding Caution
Evidence-based safety
Caution when combined
Severity and certainty are shown separately. A high-priority caution can still be theoretical: these pairings are screened from shared contraindication mechanisms and are not automatically documented clinical interactions. Provenance identifies the source fields that produced each flag; it does not upgrade the certainty of the pairwise claim.
High-Priority Caution
147 flagged pairingsBleeding / anticoagulant risk
High-Priority Caution
147 flagged pairingsBleeding / anticoagulant risk
Representative pairings are shown below. Large mechanism groups are intentionally summarized to keep profiles focused and crawl-efficient.
Bleeding / anticoagulant riskCertainty: Theoretical
Data provenance recorded for 147 of 147 pairings in this mechanism group.
- aescin — Theoretical interaction certainty
- Aged Garlic Extract — Theoretical interaction certainty
- ajoene — Theoretical interaction certainty
- Ajwain — Theoretical interaction certainty
- Allicin — Theoretical interaction certainty
- Garlic — Theoretical interaction certainty
- American Ginseng Extract — Theoretical interaction certainty
- Andrographis — Theoretical interaction certainty
- Angelica Archangelica — Theoretical interaction certainty
- Angelica Dahurica — Theoretical interaction certainty
- Angelica Pubescens — Theoretical interaction certainty
- Angelica Root — Theoretical interaction certainty
+135 more pairings share this mechanism. Use the Safety Checker to review a specific combination.
Moderate Caution
110 flagged pairingsBlood-sugar lowering
Moderate Caution
110 flagged pairingsBlood-sugar lowering
Representative pairings are shown below. Large mechanism groups are intentionally summarized to keep profiles focused and crawl-efficient.
Blood-sugar loweringCertainty: Theoretical
Data provenance recorded for 110 of 110 pairings in this mechanism group.
- Acarbose — Theoretical interaction certainty
- ajoene — Theoretical interaction certainty
- Allicin — Theoretical interaction certainty
- Aloe Vera — Theoretical interaction certainty
- Alpha-Lipoic Acid — Theoretical interaction certainty
- American Ginseng Extract — Theoretical interaction certainty
- Andrographis — Theoretical interaction certainty
- Anemarrhena Asphodeloides — Theoretical interaction certainty
- Tarragon — Theoretical interaction certainty
- Ashoka — Theoretical interaction certainty
- Astragalus — Theoretical interaction certainty
- Astragalus Membranaceus — Theoretical interaction certainty
+98 more pairings share this mechanism. Use the Safety Checker to review a specific combination.
Evidence
Evidence Summary
Evidence lens
Read as directional context, not settled clinical proof.
LimitedLimited Evidence
Human clinical evidence: Not the primary signal
Mechanistic / preclinical: Mechanism mapped — Inflammatory Signaling Modulation · Metabolic Regulation
Research maturity: Theoretical / mechanistic research — Mechanistic or unresolved evidence is kept separate from established human outcomes.
Safety boundary: Safety note available — May influence glucose or metabolic markers; monitor with antidiabetic medications and avoid pregnancy/breastfeeding use unless clinician supervised.
This profile cites 3 human studies.
Study design details
Evidence Grade
Grade C: Limited Evidence
Evaluation of methodological rigor, population reach, and evidence alignment.
- Design Match
- Narrative review
- Risk of Bias
- High
- Consistency
- Not assessed
Strongest recorded design is a narrative review, drawn from 3 recorded studies, none of which measured an outcome in people.
How evidence grades work
Each grade reflects the strength and consistency of published human evidence — not marketing claims. Grades are based on study count, design quality, effect size, consistency, and recency.
- Strong
- Multiple RCTs, consistent direction, adequate effect size
- Moderate
- Some RCTs or consistent observational data in humans
- Preliminary / Mixed
- Animal or in-vitro only, or conflicting human data
- Traditional / Theoretical
- Traditional use only; no controlled human trials
Clinical Study Summaries (3)0 human evidence sources · 0 human trials · Participant totals not consistently reported · Consistency not yet classifiable
What the evidence actually shows
This table contains 3 structured sources, including 0 human evidence sources; 0 are human trials.
| Study | Design | N | Dose | Duration | Population | Outcome | Result & magnitude | Source |
|---|---|---|---|---|---|---|---|---|
Cervantes E et al. · Plants (Basel) · 2021 Background | Narrative review Summarizes selected literature without the full prespecified search and selection methods of a systematic review. | — | — | — | — | — | — | PubMed → |
A review and evaluation of the efficacy and safety of Cissus quadrangularis extracts Stohs SJ et al. · Phytother Res · 2013 Background | Narrative review Summarizes selected literature without the full prespecified search and selection methods of a systematic review. | — | — | — | — | — | — | PubMed → |
Review of the Phytochemistry and Biological Activity of Cissus incisa Leaves Nocedo-Mena D et al. · Curr Top Med Chem · 2021 Background | Narrative review Summarizes selected literature without the full prespecified search and selection methods of a systematic review. | — | — | — | — | — | — | PubMed → |
Dosing & Timing
- No standardized dose
- Preparation specific; use standardized product label for Stem extracts/powders and require source backed dosage review before therapeutic claims.
How Cissus works
Simplified mechanism pathway based on preclinical and pharmacological evidence. Does not confirm clinical efficacy.
Mechanism Pathway — How Cissus Works
CompoundTarget / ReceptorMechanismEffect / Outcome
Mechanisms & biological pathways (preclinical)
- Inflammatory Signaling Modulation
- Metabolic Regulation
Compare related active botanicals
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Guides that use Cissus
Condition guides
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Safety first · Harm reduction
This information is educational and not medical advice. Start low, avoid risky combinations, and consult a licensed clinician before making health decisions—especially if you use medications, have diagnosed conditions, or are pregnant/breastfeeding.
Learn how we evaluate confidence, safety, and intensity on the methodology page.
Editorial Review
Checked against primary sources, cited evidence, and contraindication language before publication. Evidence claims, safety language, and affiliate modules are reviewed independently. Not personal medical advice.
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