Herb Profile
Cornus Officinalis
Botanical profile with evidence, safety, and practical fit.
Last reviewed: •3 human studies cited
C PreliminarySafety Summary: Use extra caution — Generally well tolerated for most users.
Monograph visual
Cornus Officinalis
Generated profile category visual
Key Findings
Primary reported uses
- Reproductive
- Hormonal
- Stress resilience
- Metabolic health
Preliminary
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Quick Stats
Evidence level
Limited Human Evidence
Typical onset
Varies by prep
Safety rating
Use extra caution: High caution
Best for
Reproductive, Hormonal, Stress resilience
Avoid / review if
Pregnancy/Breastfeeding Without Clinician Supervision, Known Allergy To The Plant/Family, Significant Kidney Disease Or Unstable Electrolytes
Safety & Cautions
Generally well tolerated for most users.
28%
High caution — review carefully
Detailed safety fields
Medication interactions
- - Potential Interaction Concern With Antidiabetic Medicines
- - Use Clinician Review For High Dose Extracts Or Chronic Use.
Pregnancy, breastfeeding, and contraindications
- - Pregnancy/Breastfeeding Without Clinician Supervision
- - Known Allergy To The Plant/Family
- - Significant Kidney Disease Or Unstable Electrolytes
Safety classifications
- - Interaction-Aware: Medication or interaction context is explicitly noted.
- - Pregnancy/Breastfeeding Caution: Pregnancy or breastfeeding caution language is present.
Full safety note
- - Generally well tolerated for most users.
Safety labels
- - Interaction-Aware
- - Pregnancy/Breastfeeding Caution
Caution When Combined With
These pairings share a flagged risk mechanism. This is a mechanistic caution derived from contraindication data, not a confirmed clinical interaction — consult a clinician before combining.
Moderate Caution (73)
- Aloe VeraBlood-sugar lowering
Both Aloe Vera and Cornus Officinalis are flagged for blood-sugar lowering. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
- Alpha-Lipoic AcidBlood-sugar lowering
Both Alpha-Lipoic Acid and Cornus Officinalis are flagged for blood-sugar lowering. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
- Anemarrhena AsphodeloidesBlood-sugar lowering
Both Anemarrhena Asphodeloides and Cornus Officinalis are flagged for blood-sugar lowering. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
- TarragonBlood-sugar lowering
Both Tarragon and Cornus Officinalis are flagged for blood-sugar lowering. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
- AstragalusBlood-sugar lowering
Both Astragalus and Cornus Officinalis are flagged for blood-sugar lowering. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
- Astragalus MembranaceusBlood-sugar lowering
Both Astragalus Membranaceus and Cornus Officinalis are flagged for blood-sugar lowering. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
- BerberineBlood-sugar lowering
Both Berberine and Cornus Officinalis are flagged for blood-sugar lowering. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
- BerberisBlood-sugar lowering
Both Berberis and Cornus Officinalis are flagged for blood-sugar lowering. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
- Berberis VulgarisBlood-sugar lowering
Both Berberis Vulgaris and Cornus Officinalis are flagged for blood-sugar lowering. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
- Black SeedBlood-sugar lowering
Both Black Seed and Cornus Officinalis are flagged for blood-sugar lowering. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
- BlueberryBlood-sugar lowering
Both Blueberry and Cornus Officinalis are flagged for blood-sugar lowering. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
- BuckwheatBlood-sugar lowering
Both Buckwheat and Cornus Officinalis are flagged for blood-sugar lowering. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
- BurdockBlood-sugar lowering
Both Burdock and Cornus Officinalis are flagged for blood-sugar lowering. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
- Cichorium IntybusBlood-sugar lowering
Both Cichorium Intybus and Cornus Officinalis are flagged for blood-sugar lowering. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
- CinnamonBlood-sugar lowering
Both Cinnamon and Cornus Officinalis are flagged for blood-sugar lowering. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
- CissusBlood-sugar lowering
Both Cissus and Cornus Officinalis are flagged for blood-sugar lowering. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
- CistancheBlood-sugar lowering
Both Cistanche and Cornus Officinalis are flagged for blood-sugar lowering. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
- Cistanche DeserticolaBlood-sugar lowering
Both Cistanche Deserticola and Cornus Officinalis are flagged for blood-sugar lowering. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
- Citrus BergamiaBlood-sugar lowering
Both Citrus Bergamia and Cornus Officinalis are flagged for blood-sugar lowering. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
- Citrus SinensisBlood-sugar lowering
Both Citrus Sinensis and Cornus Officinalis are flagged for blood-sugar lowering. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
- Commiphora MukulBlood-sugar lowering
Both Commiphora Mukul and Cornus Officinalis are flagged for blood-sugar lowering. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
- CoptisBlood-sugar lowering
Both Coptis and Cornus Officinalis are flagged for blood-sugar lowering. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
- Coptis ChinensisBlood-sugar lowering
Both Coptis Chinensis and Cornus Officinalis are flagged for blood-sugar lowering. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
- Coriandrum SativumBlood-sugar lowering
Both Coriandrum Sativum and Cornus Officinalis are flagged for blood-sugar lowering. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
- Curry LeafBlood-sugar lowering
Both Cornus Officinalis and Curry Leaf are flagged for blood-sugar lowering. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
- D-MannoseBlood-sugar lowering
Both Cornus Officinalis and D-Mannose are flagged for blood-sugar lowering. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
- DamianaBlood-sugar lowering
Both Cornus Officinalis and Damiana are flagged for blood-sugar lowering. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
- DandelionBlood-sugar lowering
Both Cornus Officinalis and Dandelion are flagged for blood-sugar lowering. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
- ElderberryBlood-sugar lowering
Both Cornus Officinalis and Elderberry are flagged for blood-sugar lowering. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
- EucommiaBlood-sugar lowering
Both Cornus Officinalis and Eucommia are flagged for blood-sugar lowering. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
- Garcinia IndicaBlood-sugar lowering
Both Cornus Officinalis and Garcinia Indica are flagged for blood-sugar lowering. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
- GoldensealBlood-sugar lowering
Both Cornus Officinalis and Goldenseal are flagged for blood-sugar lowering. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
- GudmarBlood-sugar lowering
Both Cornus Officinalis and Gudmar are flagged for blood-sugar lowering. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
- GymnemaBlood-sugar lowering
Both Cornus Officinalis and Gymnema are flagged for blood-sugar lowering. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
- Holy Basil / Tulsi (Ocimum tenuiflorum)Blood-sugar lowering
Both Cornus Officinalis and Holy Basil / Tulsi (Ocimum tenuiflorum) are flagged for blood-sugar lowering. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
- Holy Basil PurpleBlood-sugar lowering
Both Cornus Officinalis and Holy Basil Purple are flagged for blood-sugar lowering. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
- Holy Basil SeedBlood-sugar lowering
Both Cornus Officinalis and Holy Basil Seed are flagged for blood-sugar lowering. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
- JujubeBlood-sugar lowering
Both Cornus Officinalis and Jujube are flagged for blood-sugar lowering. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
- Kuding TeaBlood-sugar lowering
Both Cornus Officinalis and Kuding Tea are flagged for blood-sugar lowering. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
- KudzuBlood-sugar lowering
Both Cornus Officinalis and Kudzu are flagged for blood-sugar lowering. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
- BanabaBlood-sugar lowering
Both Cornus Officinalis and Banaba are flagged for blood-sugar lowering. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
- Luo Han GuoBlood-sugar lowering
Both Cornus Officinalis and Luo Han Guo are flagged for blood-sugar lowering. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
- Mangifera IndicaBlood-sugar lowering
Both Cornus Officinalis and Mangifera Indica are flagged for blood-sugar lowering. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
- MarshmallowBlood-sugar lowering
Both Cornus Officinalis and Marshmallow are flagged for blood-sugar lowering. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
- Bitter MelonBlood-sugar lowering
Both Cornus Officinalis and Bitter Melon are flagged for blood-sugar lowering. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
- Morinda CitrifoliaBlood-sugar lowering
Both Cornus Officinalis and Morinda Citrifolia are flagged for blood-sugar lowering. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
- MoringaBlood-sugar lowering
Both Cornus Officinalis and Moringa are flagged for blood-sugar lowering. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
- Morus AlbaBlood-sugar lowering
Both Cornus Officinalis and Morus Alba are flagged for blood-sugar lowering. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
- Mulberry LeafBlood-sugar lowering
Both Cornus Officinalis and Mulberry Leaf are flagged for blood-sugar lowering. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
- NeemBlood-sugar lowering
Both Cornus Officinalis and Neem are flagged for blood-sugar lowering. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
- Nelumbo NuciferaBlood-sugar lowering
Both Cornus Officinalis and Nelumbo Nucifera are flagged for blood-sugar lowering. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
- Nigella SativaBlood-sugar lowering
Both Cornus Officinalis and Nigella Sativa are flagged for blood-sugar lowering. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
- NotoginsengBlood-sugar lowering
Both Cornus Officinalis and Notoginseng are flagged for blood-sugar lowering. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
- Ocimum BasilicumBlood-sugar lowering
Both Cornus Officinalis and Ocimum Basilicum are flagged for blood-sugar lowering. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
- OreganoBlood-sugar lowering
Both Cornus Officinalis and Oregano are flagged for blood-sugar lowering. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
- American GinsengBlood-sugar lowering
Both Cornus Officinalis and American Ginseng are flagged for blood-sugar lowering. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
- Papaya LeafBlood-sugar lowering
Both Cornus Officinalis and Papaya Leaf are flagged for blood-sugar lowering. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
- PhellodendronBlood-sugar lowering
Both Cornus Officinalis and Phellodendron are flagged for blood-sugar lowering. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
- Phellodendron AmurenseBlood-sugar lowering
Both Cornus Officinalis and Phellodendron Amurense are flagged for blood-sugar lowering. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
- PsylliumBlood-sugar lowering
Both Cornus Officinalis and Psyllium are flagged for blood-sugar lowering. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
- Pueraria LobataBlood-sugar lowering
Both Cornus Officinalis and Pueraria Lobata are flagged for blood-sugar lowering. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
- Rehmannia GlutinosaBlood-sugar lowering
Both Cornus Officinalis and Rehmannia Glutinosa are flagged for blood-sugar lowering. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
- Rehmannia PreparedBlood-sugar lowering
Both Cornus Officinalis and Rehmannia Prepared are flagged for blood-sugar lowering. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
- Rice BranBlood-sugar lowering
Both Cornus Officinalis and Rice Bran are flagged for blood-sugar lowering. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
- RooibosBlood-sugar lowering
Both Cornus Officinalis and Rooibos are flagged for blood-sugar lowering. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
- Roselle SeedBlood-sugar lowering
Both Cornus Officinalis and Roselle Seed are flagged for blood-sugar lowering. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
- SageBlood-sugar lowering
Both Cornus Officinalis and Sage are flagged for blood-sugar lowering. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
- SalaciaBlood-sugar lowering
Both Cornus Officinalis and Salacia are flagged for blood-sugar lowering. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
- Serenoa RepensBlood-sugar lowering
Both Cornus Officinalis and Serenoa Repens are flagged for blood-sugar lowering. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
- ShatavariBlood-sugar lowering
Both Cornus Officinalis and Shatavari are flagged for blood-sugar lowering. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
- TamarindBlood-sugar lowering
Both Cornus Officinalis and Tamarind are flagged for blood-sugar lowering. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
- FenugreekBlood-sugar lowering
Both Cornus Officinalis and Fenugreek are flagged for blood-sugar lowering. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
- Wild YamBlood-sugar lowering
Both Cornus Officinalis and Wild Yam are flagged for blood-sugar lowering. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
Evidence Summary
PreliminaryEvidence lens
What kind of evidence supports this profile?
Early signal that needs stronger human replication before practical claims.
PreliminaryLimited Human Evidence
Human clinical evidence
Present in source signals
Human or clinical-study language is present in the reviewed fields.
Mechanistic / preclinical
Mechanism mapped
Oxidative Stress Modulation | Metabolic Regulation | Hormonal Signaling Context
Research maturity
Preliminary or mixed
Long Term Human Evidence May Be Limited.
Safety boundary
Safety note available
Generally well tolerated for most users.
This profile cites 3 human studies.
▶How evidence grades work
Each grade reflects the strength and consistency of published human evidence — not marketing claims. Grades are based on study count, design quality, effect size, consistency, and recency.
A
Strong
Multiple RCTs, consistent direction, adequate effect size
B
Moderate
Some RCTs or consistent observational data in humans
C
Preliminary / Mixed
Animal or in-vitro only, or conflicting human data
D
Traditional / Theoretical
Traditional use only; no controlled human trials
Clinical Study Summaries
3 cited studies informing this profile. RCTs and reviews shown first.
| Study | Type | Sample | Source |
|---|---|---|---|
Cornus officinalis: a potential herb for treatment of osteoporosis Tang X et al. (2023) | — | — | — |
Rehmannia glutinosa Libosch and Cornus officinalis Sieb herb couple ameliorates renal interstitial fibrosis in CKD rats by inhibiting the TGF-β1/MAPK signaling pathway Zhu JH et al. (2024) | — | — | — |
Ethnopharmacology, phytochemistry, and pharmacology of Cornus officinalis Sieb. et Zucc Huang J et al. (2018) | — | — | — |
Dosing & Timing
Dose guidance
Preparation specific; use standardized product label for Preparation varies by tradition and product form and require source backed dosage review before therapeutic claims.
How Cornus Officinalis Works
Simplified mechanism pathway based on preclinical and pharmacological evidence. Does not confirm clinical efficacy.
Mechanism Pathway — How Cornus Officinalis Works
CompoundTarget / ReceptorMechanismEffect / Outcome
Mechanisms & Biological Pathways
Preclinical pathways
Proposed mechanisms from in vitro and animal research; these do not confirm clinical outcomes in humans.
Oxidative Stress ModulationMetabolic RegulationHormonal Signaling ContextNrf2 Activation
Active Compounds
Key constituents studied in Cornus Officinalis, with full pharmacology and safety profiles.
Condition guides
Compare & Sourcing
Compare side-by-side tradeoffs or verify active marker guidelines.
Sourcing Options
Review available sources for Cornus Officinalis
Independent database mapping. Sourcing availability is evaluated separately from safety and clinical efficacy scores.
Affiliate Disclosure: Clicking verification or shopping links may earn this site a commission at no additional cost to you. Sourcing links are selected strictly based on quality criteria and availability, never based on commission tiers. Safety warnings and evidence ratings remain independent of sourcing.
Safety first · Harm reduction
This information is educational and not medical advice. Start low, avoid risky combinations, and consult a licensed clinician before making health decisions—especially if you use medications, have diagnosed conditions, or are pregnant/breastfeeding.
Learn how we evaluate confidence, safety, and intensity on the methodology page.
Editorial Review
Reviewed against source evidence and safety constraints
Profiles are checked against primary sources, cited evidence, and contraindication language before publication. This is editorial review, not personal medical advice or a named clinician endorsement.
Evidence claims are matched to human, mechanistic, or traditional-use context.
Safety language is kept conservative when interaction or population data is incomplete.
Affiliate modules are separated from evidence ratings and caution language.
Editorial Process: We synthesize preclinical pharmacology, human clinical data, and source registry context while preserving uncertainty and avoiding commercial hype.
Read Editorial Standards →Free safety checklist
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