Compound Profile

Andrographis

Andrographis has moderate human evidence for reducing upper respiratory tract infection symptoms.

Last reviewed: •1 human studies cited

B Moderate

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Andrographis

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Quick Stats

Evidence level

Moderate evidence

Typical onset

Varies by prep

Safety rating

Use extra caution: Safety review pending

Best for

NF κB, Immune Response Pathways

Avoid / review if

Pregnancy (Animal And Traditional Use Evidence Of Uterine Stimulant/Antifertility Effects), Known Acanthaceae Family Allergy, Anticoagulant/Antiplatelet Or Antihypertensive Therapy Without Monitoring

Safety & Cautions

Review before use if any apply: Pregnancy (Animal And Traditional Use Evidence Of Uterine Stimulant/Antifertility Effects), Known Acanthaceae Family Allergy, Anticoagulant/Antiplatelet Or Antihypertensive Therapy Without Monitoring.

Evidence-based safety

Caution when combined

These pairings share a flagged risk mechanism. They are additive-effect cautions derived from contraindication data, not confirmed clinical interactions. Consult a clinician before combining.

High-Priority Caution

147 flagged pairings

Bleeding / anticoagulant risk

Browse the grouped cautions below. The list scrolls inside this card when long.

Bleeding / anticoagulant risk

Moderate Caution

191 flagged pairings

Blood-sugar lowering · Blood-pressure effects

Browse the grouped cautions below. The list scrolls inside this card when long.

Blood-sugar lowering
Blood-pressure effects

Evidence Summary

B Moderate

Evidence lens

Useful signal, but study design, dose, and population still matter.

ModerateModerate evidence

Human clinical evidence: Present in source signals

Mechanistic / preclinical: Mechanism mapped — Inflammatory Signaling Modulation · Immune Signaling Modulation · NF KB Modulation

Research maturity: More interpretable — main contexts: NF κB · Immune Response Pathways

Safety boundary: Safety note available — Review before use if any apply: Pregnancy (Animal And Traditional Use Evidence Of Uterine Stimulant/Antifertility Effects), Known Acanthaceae Family Allergy, Anticoagulant/Antiplatelet Or Antihypertensive Therapy Without

This profile cites 1 human study.

Evidence Strength

Confidence estimate based on the design quality and consistency of published clinical trials.

Moderate evidence

Andrographis has a moderate evidence evidence rating.

General wellnessGeneral wellness
Citation density
0.5
Sources
1
Effects
2
Research recency
Mixed recency
How evidence grades work

Each grade reflects the strength and consistency of published human evidence — not marketing claims. Grades are based on study count, design quality, effect size, consistency, and recency.

A

Strong

Multiple RCTs, consistent direction, adequate effect size

B

Moderate

Some RCTs or consistent observational data in humans

C

Preliminary / Mixed

Animal or in-vitro only, or conflicting human data

D

Traditional / Theoretical

Traditional use only; no controlled human trials

Clinical Study Summaries (1)Cited studies informing this profile. RCTs and reviews shown first.
StudyTypeSampleSource

PubMed PMID 15095142. Minimal citation row added from existing workbook PMID; title/year/journal still require PubMed metadata extraction.

PubMed

——PubMed →

How Andrographis Works

Simplified mechanism pathway based on preclinical and pharmacological evidence. Does not confirm clinical efficacy.

Mechanism Pathway — How Andrographis Works

How Andrographis WorksAndrographis acts on pathways via anti inflammatory, leading to nf κb.AndrographisBiological pathwayAnti InflammatoryNf κBObservable outcomeImmune ModulationParallel pathway
CompoundTarget / ReceptorMechanismEffect / Outcome
Mechanisms & Biological Pathways▼

Preclinical mechanism details from scientific profiles; these represent plausible pathways but do not guarantee clinical efficacy in humans.

Inflammatory Signaling ModulationImmune Signaling ModulationNF KB ModulationInflammatory

Condition guides

InflammationAnxietyBlood pressureCognitionEnergy

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Related research paths

Compare & Sourcing

Compare side-by-side tradeoffs or verify active marker guidelines.

Review available sources for Andrographis

Independent database mapping — evaluated separately from safety and efficacy scores.

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Related alternatives

Aloe VeraAndrographis PaniculataArtemisia AnnuaAstragalus Membranaceus

Herbs for similar conditions

Ginger Zingiber officinaleAngelica SinensisBayberryBuckwheat

Tradeoffs

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Affiliate-ready sourcing

Andrographis product picks

Affiliate recommendations for Andrographis. Review safety, dose, and product quality before buying.

Affiliate disclosure: we may earn a commission from qualifying links at no extra cost to you. How we stay independent.

Budget pick

NOW Foods

NOW Andrographis Extract 400 mg

Budget pick for andrographolide-standardized andrographis extract for immune and respiratory support.

Check current price

Best overall

Integrative Therapeutics

Integrative Therapeutics Andrographis Plus

Best overall for a KalmAssure or clinically validated andrographis extract standardized to andrographolide.

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Premium pick

Pure Encapsulations

Pure Encapsulations Andrographis

Premium hypoallergenic andrographis capsule for practitioners and sensitive patients.

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Product Form & Quality Guidelines

When sourcing Andrographis, verify the label for:

  • Standardized Extract: Confirm active content percentages on the supplement facts panel (e.g. standardized to specific marker compounds) rather than simple raw herb weights.
  • Third-Party Testing: Look for independent purity labels (USP, NSF, ConsumerLab, or Eurofins) to ensure the product is free from heavy metals, solvents, and contaminants.
  • Form Bioavailability: Ensure the form matches evidence-supported configurations (e.g. chelated bisglycinate/glycinate for magnesium, micronized monohydrate for creatine) for optimal onset and digestion tolerance.

Safety first · Harm reduction

This information is educational and not medical advice. Start low, avoid risky combinations, and consult a licensed clinician before making health decisions—especially if you use medications, have diagnosed conditions, or are pregnant/breastfeeding.

Learn how we evaluate confidence, safety, and intensity on the methodology page.

Editorial Review

Checked against primary sources, cited evidence, and contraindication language before publication. Evidence claims, safety language, and affiliate modules are reviewed independently. Not personal medical advice.

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Compound profile context

How to interpret Andrographis

Andrographis dosage by use case, onset and duration, safety limits, and interactions for nf κb, graded against research. Moderate Human Evidence research… Use this compound profile to understand mechanism, evidence quality, and practical safety context before comparing products or building a stack. A biochemical pathway connection can be useful for discovery, but it is not the same as proven benefit in humans.

When reviewing Andrographis, separate the active molecule from the product category around it. Dose form, absorption, extract standardization, medication interactions, and individual sensitivity can change the real-world risk-benefit picture.

For supplement planning, avoid combining multiple compounds with overlapping sedating, stimulating, serotonergic, blood-pressure, anticoagulant, or liver-metabolism effects unless a qualified clinician has reviewed the context.