Compound Profile
Andrographolide
Decision ready summary: Andrographolide is best framed for upper respiratory symptom support; immune response modulation; safety screen: pregnancy; autoimmune disease caution; anticoagulants.
Last reviewed: •1 human studies cited
C PreliminaryMonograph visual
Andrographolide
Generated profile category visual
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Quick Stats
Evidence level
Preliminary evidence
Typical onset
Varies by prep
Safety rating
Use extra caution: Use caution
Best for
NF κB, Nrf2, JAK/STAT
Avoid / review if
Pregnancy
Found In
Botanicals that contain Andrographolide, with full herb profiles.
Safety & Cautions
Review before use if any apply: Pregnancy.
Evidence Summary
C PreliminaryEvidence lens
Useful signal, but study design, dose, and population still matter.
ModeratePreliminary evidence
Human clinical evidence: Present in source signals
Mechanistic / preclinical: Mechanism mapped — Inflammatory Signaling Modulation · Oxidative Stress Modulation · Mitochondrial Support
Research maturity: More interpretable — main contexts: NF κB · Nrf2 · JAK/STAT
Safety boundary: Safety note available — Review before use if any apply: Pregnancy.
This profile cites 1 human study.
Evidence Strength
Confidence estimate based on the design quality and consistency of published clinical trials.
Andrographolide has a preliminary evidence evidence rating.
AdaptogenStress & MoodLongevity
Citation density
0.2
Sources
1
Effects
6
Research recency
Mixed recency
How evidence grades work
Each grade reflects the strength and consistency of published human evidence — not marketing claims. Grades are based on study count, design quality, effect size, consistency, and recency.
A
Strong
Multiple RCTs, consistent direction, adequate effect size
B
Moderate
Some RCTs or consistent observational data in humans
C
Preliminary / Mixed
Animal or in-vitro only, or conflicting human data
D
Traditional / Theoretical
Traditional use only; no controlled human trials
Clinical Study Summaries (1)Cited studies informing this profile. RCTs and reviews shown first.
How Andrographolide Works
Simplified mechanism pathway based on preclinical and pharmacological evidence. Does not confirm clinical efficacy.
Mechanism Pathway — How Andrographolide Works
CompoundTarget / ReceptorMechanismEffect / Outcome
Mechanisms & Biological Pathways▼
Preclinical mechanism details from scientific profiles; these represent plausible pathways but do not guarantee clinical efficacy in humans.
Inflammatory Signaling ModulationOxidative Stress ModulationMitochondrial SupportImmune Signaling ModulationNF KB ModulationNrf2 Activation
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Compare & Sourcing
Compare side-by-side tradeoffs or verify active marker guidelines.
Review available sources for Andrographolide
Independent database mapping — evaluated separately from safety and efficacy scores.
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Related alternatives
Herbs for similar conditions
Tradeoffs
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Safety first · Harm reduction
This information is educational and not medical advice. Start low, avoid risky combinations, and consult a licensed clinician before making health decisions—especially if you use medications, have diagnosed conditions, or are pregnant/breastfeeding.
Learn how we evaluate confidence, safety, and intensity on the methodology page.
Editorial Review
Checked against primary sources, cited evidence, and contraindication language before publication. Evidence claims, safety language, and affiliate modules are reviewed independently. Not personal medical advice.
Compound profile context
How to interpret Andrographolide
Andrographolide dosage by use case, onset and duration, safety limits, and interactions for nf κb, graded against research. Mechanistic Evidence research… Use this compound profile to understand mechanism, evidence quality, and practical safety context before comparing products or building a stack. A biochemical pathway connection can be useful for discovery, but it is not the same as proven benefit in humans.
When reviewing Andrographolide, separate the active molecule from the product category around it. Dose form, absorption, extract standardization, medication interactions, and individual sensitivity can change the real-world risk-benefit picture.
For supplement planning, avoid combining multiple compounds with overlapping sedating, stimulating, serotonergic, blood-pressure, anticoagulant, or liver-metabolism effects unless a qualified clinician has reviewed the context.