Compound Profile

Andrographolide

Immune response modulation; safety screen: pregnancy; autoimmune disease caution; anticoagulants.

Last reviewed: •1 source citedReport a correctionProfile-wide ·D Preliminary

Use extra caution — Avoid in pregnancy; immune modulating framing needs caution with autoimmune conditions. Details

Evidence
Preliminary evidence
Typical onset
Varies by prep
Safety rating
Use extra caution: Use caution
Best for
NF κB, Nrf2, JAK/STAT
Avoid / review if
Pregnancy
Next steps

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Andrographolide monograph visual
Generated profile category visual

Safety

Safety & Cautions

Avoid in pregnancy; immune modulating framing needs caution with autoimmune conditions.

High caution

Caution level: High. Multiple caution categories apply, or the record uses avoid/contraindication language.

Evidence Summary

Profile-wide ·D Preliminary

Evidence lens

Early signal that needs stronger human replication before practical claims.

PreliminaryPreliminary evidence

Human clinical evidence: Present in source signals

Mechanistic / preclinical: Mechanism mapped — Inflammatory Signaling Modulation · Oxidative Stress Modulation · Mitochondrial Support

Research maturity: Preliminary research — Early findings are not treated as established consumer benefit.

Safety boundary: Safety note available — Avoid in pregnancy; immune modulating framing needs caution with autoimmune conditions.

This profile cites 1 human study.

Evidence Strength

Confidence estimate based on the design quality and consistency of published clinical trials.

Preliminary evidence

Andrographolide has a preliminary evidence rating.

AdaptogenStress & MoodLongevity
Citation density
0.2
Sources
1
Effects
6
Research recency
Mixed recency
Evidence Grade

Grade D: Preliminary / Theoretical Evidence

Evaluation of methodological rigor, population reach, and evidence alignment.

Design Match
Systematic review
Risk of Bias
Low
Consistency
Not assessed
Strongest recorded design is a systematic review, drawn from 1 recorded study, 1 in people.
How evidence grades work

Each grade reflects the strength and consistency of published human evidence — not marketing claims. Grades are based on study count, design quality, effect size, consistency, and recency.

Strong
Multiple RCTs, consistent direction, adequate effect size
Moderate
Some RCTs or consistent observational data in humans
Preliminary / Mixed
Animal or in-vitro only, or conflicting human data
Traditional / Theoretical
Traditional use only; no controlled human trials
Clinical Study Summaries (1)1 human evidence source · 0 human trials · Participant totals not consistently reported · Consistency not yet classifiable

What the evidence actually shows

This table contains 1 structured source, including 1 human evidence source; 0 are human trials.

StudyDesignNDoseDurationPopulationOutcomeResult & magnitudeSource

Andrographis paniculata in the treatment of upper respiratory tract infections: a systematic review of safety and efficacy

PubMed · Planta Med · 2004

Background
Systematic review

Uses a predefined method to find and evaluate relevant studies, but may or may not pool their results statistically.

——————PubMed →

How Andrographolide Works

Simplified mechanism pathway based on preclinical and pharmacological evidence. Does not confirm clinical efficacy.

Mechanism Pathway — How Andrographolide Works

How Andrographolide WorksAndrographolide acts on biological target pathways via anti inflammatory, leading to nf κb.AndrographolideBiological TargetBiological pathwayAnti InflammatoryNf κBObservable outcomeAntioxidantParallel pathway
CompoundTarget / ReceptorMechanismEffect / Outcome

Dosing

Common form
capsule or standardized extract
No standardized dose
Our source data records the usual product form for this ingredient but no studied dose. Preparations differ widely, so follow the standardization on the product you actually have and speak to a clinician before starting.
Mechanisms & biological pathways

Preclinical mechanism details from scientific profiles; these represent plausible pathways but do not guarantee clinical efficacy in humans.

  • Inflammatory Signaling Modulation
  • Oxidative Stress Modulation
  • Mitochondrial Support
  • Immune Signaling Modulation
  • NF KB Modulation
  • Nrf2 Activation

Botanical Context

Source botanicals and comparison guides related to Andrographolide.

Found in

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Compare & Sourcing

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Safety first · Harm reduction

This information is educational and not medical advice. Start low, avoid risky combinations, and consult a licensed clinician before making health decisions—especially if you use medications, have diagnosed conditions, or are pregnant/breastfeeding.

Learn how we evaluate confidence, safety, and intensity on the methodology page.

By Willie B. Randolph III

Founder & Head Researcher · Oak Ridge, TN · Last reviewed August 2026

Editorial Review

Checked against primary sources, cited evidence, and contraindication language before publication. Evidence claims, safety language, and affiliate modules are reviewed independently. Not personal medical advice.

Editorial Standards →

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