Herb Profile

Eucommia

Eucommia ulmoides

Eucommia (Eucommia ulmoides) carries a Grade C rating — limited evidence.

Last reviewed: •3 sources citedReport a correctionProfile-wide ·C Limited

Use extra caution — May affect circulation, blood pressure, or platelet function; use caution with anticoagulants/antiplatelets, antihypertensives, heart medications, and before surgery. Details

Evidence
Limited Evidence
Typical onset
Varies by prep
Safety rating
Moderate caution
Best for
Metabolic, Tonic
Avoid / review if
Pregnancy/Breastfeeding Without Clinician Guidance, Hypotension Or Hypoglycemia Risk, May Potentiate Antihypertensive Or Antidiabetic Agents.
Eucommia monograph visual
Generated profile category visual

At a glance

From this profile's structured data
Evidence
Grade C
Safety
May affect circulation, blood pressure, or platelet function; use caution with anticoagulants/antiplatelets, antihypertensives, heart medications, and before surgery.
Profile context
metabolic, tonic
Next steps

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Safety

Safety & Cautions

May affect circulation, blood pressure, or platelet function; use caution with anticoagulants/antiplatelets, antihypertensives, heart medications, and before surgery.

Elevated caution

Caution level: Elevated. One caution category applies — read it before use.

  • Pregnancy/Breastfeeding CautionPregnancy or breastfeeding caution language is present.
Detailed safety fields

Pregnancy, breastfeeding, and contraindications

  • Pregnancy/Breastfeeding Without Clinician Guidance
  • Hypotension Or Hypoglycemia Risk
  • May Potentiate Antihypertensive Or Antidiabetic Agents.

Safety classifications

  • Pregnancy/Breastfeeding Caution: Pregnancy or breastfeeding caution language is present.

Full safety note

  • May affect circulation, blood pressure, or platelet function; use caution with anticoagulants/antiplatelets, antihypertensives, heart medications, and before surgery.

Safety labels

  • Pregnancy/Breastfeeding Caution

Evidence-based safety

Caution when combined

Severity and certainty are shown separately. A high-priority caution can still be theoretical: these pairings are screened from shared contraindication mechanisms and are not automatically documented clinical interactions. Provenance identifies the source fields that produced each flag; it does not upgrade the certainty of the pairwise claim.

Moderate Caution

191 flagged pairings

Blood-sugar lowering · Blood-pressure effects

Representative pairings are shown below. Large mechanism groups are intentionally summarized to keep profiles focused and crawl-efficient.

Blood-sugar loweringCertainty: Theoretical

Data provenance recorded for 110 of 110 pairings in this mechanism group.

+98 more pairings share this mechanism. Use the Safety Checker to review a specific combination.

Blood-pressure effectsCertainty: Theoretical

Data provenance recorded for 81 of 81 pairings in this mechanism group.

+69 more pairings share this mechanism. Use the Safety Checker to review a specific combination.

Evidence

Evidence Summary

Evidence lens

Read as directional context, not settled clinical proof.

LimitedLimited Evidence

Human clinical evidence: Not the primary signal

Mechanistic / preclinical: Mechanism mapped — Metabolic Regulation · Vascular Function Support

Research maturity: Theoretical / mechanistic research — Mechanistic or unresolved evidence is kept separate from established human outcomes.

Safety boundary: Safety note available — May affect circulation, blood pressure, or platelet function; use caution with anticoagulants/antiplatelets, antihypertensives, heart medications, and before surgery.

This profile cites 3 human studies.

How evidence grades work

Each grade reflects the strength and consistency of published human evidence — not marketing claims. Grades are based on study count, design quality, effect size, consistency, and recency.

Strong
Multiple RCTs, consistent direction, adequate effect size
Moderate
Some RCTs or consistent observational data in humans
Preliminary / Mixed
Animal or in-vitro only, or conflicting human data
Traditional / Theoretical
Traditional use only; no controlled human trials
Clinical Study Summaries (3)0 human evidence sources · 0 human trials · Participant totals not consistently reported · Consistency not yet classifiable

What the evidence actually shows

This table contains 3 structured sources, including 0 human evidence sources; 0 are human trials.

StudyDesignNDoseDurationPopulationOutcomeResult & magnitudeSource

Somatostatin and Mannooligosaccharide Modified Selenium Nanoparticles with Dual-Targeting for Ulcerative Colitis Treatment

Ye R et al. · ACS Nano · 2025

Background
Other / unclear

The study design is not yet classified clearly enough to infer its place in the evidence hierarchy.

——————PubMed →

Aqueous extract of fermented Eucommia ulmoides leaves alleviates hyperlipidemia by maintaining gut homeostasis and modulating metabolism in high-fat diet fed rats

Duan Y et al. · Phytomedicine · 2024

Background
Other / unclear

The study design is not yet classified clearly enough to infer its place in the evidence hierarchy.

——————PubMed →

Eucommia ulmoides Oliver (Duzhong) extract ameliorates cerebral ischemic stroke in mice by remodeling intestinal microbiota and metabolites

Qi X et al. · Metab Brain Dis · 2025

Background
Other / unclear

The study design is not yet classified clearly enough to infer its place in the evidence hierarchy.

——————PubMed →

Dosing & Timing

No standardized dose
Preparation specific; use standardized product label for Bark/leaf tea and require source backed dosage review before therapeutic claims.
How Eucommia works

Simplified mechanism pathway based on preclinical and pharmacological evidence. Does not confirm clinical efficacy.

Mechanism Pathway — How Eucommia Works

How Eucommia WorksEucommia acts on biological target pathways via metabolic (regulation), leading to metabolic.EucommiaBiological TargetBiological pathwayMetabolicRegulationMetabolicObservable outcomeVascular FunctionSupport
CompoundTarget / ReceptorMechanismEffect / Outcome
Mechanisms & biological pathways (preclinical)
  • Metabolic Regulation
  • Vascular Function Support

Active Compounds

Key constituents studied in Eucommia, with full pharmacology and safety profiles.

Compare related active botanicals

Explore botanicals with similar chemistry, effects, or safety considerations in the Botanical Activity Atlas.

Guides that use Eucommia

Condition guides

Compare & Sourcing

Compare side-by-side tradeoffs or verify active marker guidelines.

Safety first · Harm reduction

This information is educational and not medical advice. Start low, avoid risky combinations, and consult a licensed clinician before making health decisions—especially if you use medications, have diagnosed conditions, or are pregnant/breastfeeding.

Learn how we evaluate confidence, safety, and intensity on the methodology page.

Editorial Review

Checked against primary sources, cited evidence, and contraindication language before publication. Evidence claims, safety language, and affiliate modules are reviewed independently. Not personal medical advice.

Editorial Standards →

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