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Compound Profile
Garcinol
Polyisoprenylated benzophenone from Garcinia indica with HAT inhibitory and anti inflammatory activity.
Use extra caution — Safety evidence: review level evidence remains preclinical, with human trials lacking. Details
Last reviewed: •1 source citedReport a correctionProfile-wide ·C Limited
At a glance
From this profile's structured data- Evidence
- Grade C
- Safety
- Safety evidence: review-level evidence remains preclinical, with human trials lacking.
- Profile context
- NF-κB, antioxidant response, apoptosis signaling
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Quick stats
- Evidence level
- Limited evidence
- Typical onset
- Varies by prep
- Safety rating
- Use extra caution: Interaction risk
- Best for
- NF κB, Antioxidant Response, Apoptosis Signaling
Botanical Context
Source botanicals and comparison guides related to Garcinol.
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Safety
Safety & Cautions
High caution
Caution level: High. Multiple caution categories apply, or the record uses avoid/contraindication language.
- Interaction-AwareMedication or interaction context is explicitly noted.
- Liver-SensitiveLiver-related caution language appears in the profile.
- Anticoagulant CautionBleeding or anticoagulant-adjacent caution language is present.
- Pregnancy/Breastfeeding CautionPregnancy or breastfeeding caution language is present.
- Safety evidence
- review-level evidence remains preclinical, with human trials lacking
- Who should avoid this?
- No specific evidence-backed contraindication is documented for this profile. This is not the same as established safety.
- Talk to a professional if
- you use relevant medications, you are pregnant or breastfeeding, surgery is planned or recent, you have a condition named in this safety summary.
Human dose-response, pregnancy, breastfeeding, bleeding, surgery, liver, kidney, chemotherapy, and medication-interaction safety cannot be inferred from Garcinia extracts or cell and animal studies.
Evidence Summary
Profile-wide ·C LimitedEvidence lens
Read as directional context, not settled clinical proof.
LimitedLimited evidence
Human clinical evidence: Not the primary signal
Mechanistic / preclinical: Mechanism mapped — Inflammatory Signaling Modulation · Oxidative Stress Modulation · Immune Signaling Modulation
Research maturity: Theoretical / mechanistic research — Mechanistic or unresolved evidence is kept separate from established human outcomes.
Safety boundary: Safety note available — Safety evidence: review level evidence remains preclinical, with human trials lacking.
This profile cites 1 human study.
Evidence Strength
Confidence estimate based on the design quality and consistency of published clinical trials.
Garcinol has a limited evidence rating.
AdaptogenStress & MoodLongevity
Citation density
0.5
Sources
2
Effects
4
Research recency
Mixed recency
Evidence Grade
Grade C: Limited Evidence
Evaluation of methodological rigor, population reach, and evidence alignment.
- Design Match
- Narrative review
- Risk of Bias
- High
- Consistency
- Not assessed
Strongest recorded design is a narrative review, drawn from 1 recorded study, none of which measured an outcome in people.
How evidence grades work
Each grade reflects the strength and consistency of published human evidence — not marketing claims. Grades are based on study count, design quality, effect size, consistency, and recency.
- Strong
- Multiple RCTs, consistent direction, adequate effect size
- Moderate
- Some RCTs or consistent observational data in humans
- Preliminary / Mixed
- Animal or in-vitro only, or conflicting human data
- Traditional / Theoretical
- Traditional use only; no controlled human trials
Clinical Study Summaries (2)0 human evidence sources · 0 human trials · Participant totals not consistently reported · Consistency not yet classifiable
Filter by study class
Showing 2 of 2 studies.
What the evidence actually shows
This table contains 2 structured sources, including 0 human evidence sources; 0 are human trials.
| Study | Design | N | Dose | Duration | Population | Outcome | Result & magnitude | Source |
|---|---|---|---|---|---|---|---|---|
HAT/HDAC inhibition; anti-inflammatory. Kopytko P et al. · Int J Mol Sci · 2021 Background | Narrative review Summarizes selected literature without the full prespecified search and selection methods of a systematic review. | — | — | — | — | — | — | PubMed → |
HAT/HDAC inhibition; anti-inflammatory. Son SI et al. · ACS Chem Biol · 2020 Background | Other / unclear The study design is not yet classified clearly enough to infer its place in the evidence hierarchy. | — | — | — | — | — | — | PubMed → |
How Garcinol Works
Simplified mechanism pathway based on preclinical and pharmacological evidence. Does not confirm clinical efficacy.
Mechanism Pathway — How Garcinol Works
CompoundTarget / ReceptorMechanismEffect / Outcome
Dosing
- Common form
- standardized extract capsule
- No standardized dose
- Our source data records the usual product form for this ingredient but no studied dose. Preparations differ widely, so follow the standardization on the product you actually have and speak to a clinician before starting.
Mechanisms & biological pathways
Preclinical mechanism details from scientific profiles; these represent plausible pathways but do not guarantee clinical efficacy in humans.
- Inflammatory Signaling Modulation
- Oxidative Stress Modulation
- Immune Signaling Modulation
- NF KB Modulation
- Oxidative Stress
Guides that use Garcinol
Condition guides
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Compare & Sourcing
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Safety first · Harm reduction
This information is educational and not medical advice. Start low, avoid risky combinations, and consult a licensed clinician before making health decisions—especially if you use medications, have diagnosed conditions, or are pregnant/breastfeeding.
Learn how we evaluate confidence, safety, and intensity on the methodology page.
Editorial Review
Checked against primary sources, cited evidence, and contraindication language before publication. Evidence claims, safety language, and affiliate modules are reviewed independently. Not personal medical advice.
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