Compound Profile
Green Tea Extract / EGCG
Cardiometabolic markers; antioxidant polyphenol intake; safety screen: liver disease; high dose fasting use; stimulant sensitivity.
Last reviewed: •1 source citedReport a correctionProfile-wide ·B Moderate
Use extra caution — Safety evidence: limited human safety evidence and rare case reports. Details
- Evidence
- Moderate evidence
- Typical onset
- Varies by prep
- Safety rating
- Use extra caution: Use caution
- Best for
- Oxidative Stress, Mitochondrial Health, Metabolic Health
- Avoid / review if
- Verify Caffeine Content If Stimulant Sensitive.
Safety
Safety & Cautions
High caution
Caution level: High. Multiple caution categories apply, or the record uses avoid/contraindication language.
- Liver-SensitiveLiver-related caution language appears in the profile.
- Stimulant-Like ProfileStimulant-like or activating caution language is present.
- Safety evidence
- limited human safety evidence and rare case reports
- Who should avoid this?
- Verify Caffeine Content If Stimulant Sensitive.
- Talk to a professional if
- you have a condition named in this safety summary.
Concentrated green tea or EGCG extracts can cause liver injury, particularly with high-dose or fasting exposure; caffeine content and risk vary by preparation.
Evidence Summary
Profile-wide ·B ModerateEvidence lens
Useful signal, but study design, dose, and population still matter.
ModerateModerate evidence
Human clinical evidence: Not the primary signal
Mechanistic / preclinical: Mechanism mapped — Metabolic Regulation · AMPK Signaling Modulation · Oxidative Stress Modulation
Research maturity: Theoretical / mechanistic research — Mechanistic or unresolved evidence is kept separate from established human outcomes.
Safety boundary: Safety note available — Safety evidence: limited human safety evidence and rare case reports.
This profile cites 1 human study.
Evidence Strength
Confidence estimate based on the design quality and consistency of published clinical trials.
Green Tea Extract / EGCG has a moderate evidence rating.
AdaptogenStress & MoodLongevity
Citation density
0.2
Sources
1
Effects
5
Research recency
Mixed recency
Evidence Grade
Grade B: Moderate Evidence
Evaluation of methodological rigor, population reach, and evidence alignment.
- Design Match
- Meta analysis
- Risk of Bias
- Low
- Consistency
- Not assessed
Strongest recorded design is a meta analysis, drawn from 2 recorded studies, 1 in people.
How evidence grades work
Each grade reflects the strength and consistency of published human evidence — not marketing claims. Grades are based on study count, design quality, effect size, consistency, and recency.
- Strong
- Multiple RCTs, consistent direction, adequate effect size
- Moderate
- Some RCTs or consistent observational data in humans
- Preliminary / Mixed
- Animal or in-vitro only, or conflicting human data
- Traditional / Theoretical
- Traditional use only; no controlled human trials
Clinical Study Summaries (1)0 human evidence sources · 0 human trials · Participant totals not consistently reported · Consistency not yet classifiable
What the evidence actually shows
This table contains 1 structured source, including 0 human evidence sources; 0 are human trials.
| Study | Design | N | Dose | Duration | Population | Outcome | Result & magnitude | Source |
|---|---|---|---|---|---|---|---|---|
Capasso L et al. · Molecules · 2025 Background | Narrative review Summarizes selected literature without the full prespecified search and selection methods of a systematic review. | — | — | — | — | — | — | PubMed → |
How Green Tea Extract / EGCG Works
Simplified mechanism pathway based on preclinical and pharmacological evidence. Does not confirm clinical efficacy.
Mechanism Pathway — How Green Tea Extract / EGCG Works
CompoundTarget / ReceptorMechanismEffect / Outcome
Dosing
- No standardized dose
- No standardized dose is established for this ingredient in our source data. Preparations differ widely, so follow the standardization on the product you actually have and speak to a clinician before starting.
Mechanisms & biological pathways
Preclinical mechanism details from scientific profiles; these represent plausible pathways but do not guarantee clinical efficacy in humans.
- Metabolic Regulation
- AMPK Signaling Modulation
- Oxidative Stress Modulation
Botanical Context
Source botanicals and comparison guides related to Green Tea Extract / EGCG.
Compare & Sourcing
Compare side-by-side tradeoffs or verify active marker guidelines.
Safety first · Harm reduction
This information is educational and not medical advice. Start low, avoid risky combinations, and consult a licensed clinician before making health decisions—especially if you use medications, have diagnosed conditions, or are pregnant/breastfeeding.
Learn how we evaluate confidence, safety, and intensity on the methodology page.
Founder & Head Researcher · Oak Ridge, TN · Last reviewed August 2026
Editorial Review
Checked against primary sources, cited evidence, and contraindication language before publication. Evidence claims, safety language, and affiliate modules are reviewed independently. Not personal medical advice.
Help improve this profile
Was this useful for your research?
These controls record only the page and the structured choice you make when analytics consent is enabled. Please don’t include personal medical information in research requests.
Was this evidence summary clear?
Did you find what you were researching?
Free safety checklist
Get the Green Tea Extract / EGCG evidence notes
Occasional research updates, safety context, and product-quality checks for supplement decisions.
We use your email to send the checklist and occasional evidence-first supplement updates. Unsubscribe anytime. Privacy policy.