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Compounds connected by the same goals, effects, or research topics.
Compound Profile
Hawthorn Extract
Hawthorn Extract is best framed as a conservative research profile with mechanistic evidence and a focus on Cardiovascular Health.
Use extra caution — Dizziness, hypotension; interacts with cardiac medications. Details
Last reviewed: •2 sources citedReport a correctionProfile-wide ·C Limited
At a glance
From this profile's structured data- Evidence
- Grade C
- Safety
- Dizziness, hypotension; interacts with cardiac medications.
- Profile context
- vascular tone, cardiac contractility
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Quick stats
- Evidence level
- Limited evidence
- Typical onset
- Varies by prep
- Safety rating
- Use extra caution: Interaction risk
- Best for
- Vascular Tone, Cardiac Contractility
- Avoid / review if
- Cardiovascular
Safety
Safety & Cautions
Dizziness, hypotension; interacts with cardiac medications.
Elevated caution
Caution level: Elevated. One caution category applies — read it before use.
- Interaction-AwareMedication or interaction context is explicitly noted.
Evidence Summary
Profile-wide ·C LimitedEvidence lens
Read as directional context, not settled clinical proof.
LimitedLimited evidence
Human clinical evidence: Present in source signals
Mechanistic / preclinical: Mechanism mapped — Vascular Function Support · Cardiac Contractility Signaling · Endothelial Signaling Modulation
Research maturity: Emerging research — main contexts: Vascular Tone · Cardiac Contractility
Safety boundary: Safety note available — Dizziness, hypotension; interacts with cardiac medications.
This profile cites 2 human studies.
Evidence Strength
Confidence estimate based on the design quality and consistency of published clinical trials.
Hawthorn Extract has a limited evidence rating.
NootropicFocus
Citation density
1.0
Sources
2
Effects
2
Research recency
Mixed recency
Evidence Grade
Grade C: Limited Evidence
Evaluation of methodological rigor, population reach, and evidence alignment.
- Design Match
- Randomized controlled trial
- Risk of Bias
- Low
- Consistency
- Not assessed
Strongest recorded design is a randomized controlled trial, drawn from 2 recorded studies, 2 in people.
How evidence grades work
Each grade reflects the strength and consistency of published human evidence — not marketing claims. Grades are based on study count, design quality, effect size, consistency, and recency.
- Strong
- Multiple RCTs, consistent direction, adequate effect size
- Moderate
- Some RCTs or consistent observational data in humans
- Preliminary / Mixed
- Animal or in-vitro only, or conflicting human data
- Traditional / Theoretical
- Traditional use only; no controlled human trials
Clinical Study Summaries (2)1 human evidence source · 1 human trial · Participant totals not consistently reported · Consistency not yet classifiable
Filter by study class
Showing 2 of 2 studies.
What the evidence actually shows
This table contains 2 structured sources, including 1 human evidence source; 1 is a human trial. A reliable participant total cannot be calculated because sample size is not consistently structured in the cited sources. Source-to-conclusion relationships are not classified in this structured set, so consistency is not yet classifiable.
Profile-wide evidence grade: see the profile grade above · Confidence: not separately assigned
What would change our conclusion?
Larger, well-controlled human trials using comparable populations, doses, preparations, and clinically meaningful outcomes could materially strengthen or weaken this conclusion. Replication in a different population or a high-quality synthesis resolving current disagreement could also materially change confidence.
| Study | Design | N | Dose | Duration | Population | Outcome | Result & magnitude | Source |
|---|---|---|---|---|---|---|---|---|
Hawthorn Extract Randomized Blinded Chronic Heart Failure (HERB CHF) trial PubMed · Eur J Heart Fail · 2009 Background | Randomized controlled trial Randomly assigns participants to interventions or controls, reducing many sources of bias when the trial is conducted well. | — | — | — | — | — | — | PubMed → |
Hematospermia associated with congenital arteriovenous malformation of internal iliac vessels Suzuki K et al. · Int J Urol · 2007 Background | Other / unclear The study design is not yet classified clearly enough to infer its place in the evidence hierarchy. | — | — | — | — | — | — | PubMed → |
How Hawthorn Extract Works
Simplified mechanism pathway based on preclinical and pharmacological evidence. Does not confirm clinical efficacy.
Mechanism Pathway — How Hawthorn Extract Works
CompoundTarget / ReceptorMechanismEffect / Outcome
Dosing
- Common form
- standardized extract
- No standardized dose
- Our source data records the usual product form for this ingredient but no studied dose. Preparations differ widely, so follow the standardization on the product you actually have and speak to a clinician before starting.
Mechanisms & biological pathways
Preclinical mechanism details from scientific profiles; these represent plausible pathways but do not guarantee clinical efficacy in humans.
- Vascular Function Support
- Cardiac Contractility Signaling
- Endothelial Signaling Modulation
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Compare & Sourcing
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Review available sources for Hawthorn Extract
Independent database mapping — evaluated separately from safety and efficacy scores.
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Safety first · Harm reduction
This information is educational and not medical advice. Start low, avoid risky combinations, and consult a licensed clinician before making health decisions—especially if you use medications, have diagnosed conditions, or are pregnant/breastfeeding.
Learn how we evaluate confidence, safety, and intensity on the methodology page.
Editorial Review
Checked against primary sources, cited evidence, and contraindication language before publication. Evidence claims, safety language, and affiliate modules are reviewed independently. Not personal medical advice.
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Compound profile context
How to interpret Hawthorn Extract
Hawthorn Extract compound profile with evidence context, key research topics, source notes, safety context, and references presented in an evidence-first… Use this compound profile to understand mechanism, evidence quality, and practical safety context before comparing products or building a stack. A biochemical pathway connection can be useful for discovery, but it is not the same as proven benefit in humans.
When reviewing Hawthorn Extract, separate the active molecule from the product category around it. Dose form, absorption, extract standardization, medication interactions, and individual sensitivity can change the real-world risk-benefit picture.
For supplement planning, avoid combining multiple compounds with overlapping sedating, stimulating, serotonergic, blood-pressure, anticoagulant, or liver-metabolism effects unless a qualified clinician has reviewed the context.