Compound Profile

Indole 3 Carbinol

Indole 3 carbinol is a indole compound associated with cruciferous vegetables.

Last reviewed: Report a correctionProfile-wide ·Unassigned

Generally well tolerated — Generally safe with limited long term data | Generally safe; high dose effects unclear Details

Typical onset
Varies by prep
Safety rating
Generally well tolerated: Generally well tolerated
Best for
Estrogen Receptors, CYP Enzymes, CYP1A1 CYP1B1
Next steps

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Indole 3 Carbinol monograph visual
Generated profile category visual

Safety

Safety & Cautions

Generally safe with limited long term data | Generally safe; high dose effects unclear

Elevated caution

Caution level: Elevated. One caution category applies — read it before use.

  • Hormonal Activity ContextHormone-adjacent wording is present and should be interpreted carefully.

Evidence Summary

Profile-wide ·Unassigned

Evidence lens

Treat this profile as unresolved until source review is complete.

Needs reviewNeeds review

Human clinical evidence: Not the primary signal

Mechanistic / preclinical: Mechanism mapped — Phase I/II Detoxification Enzyme Regulation (Preclinical) · Estrogen Metabolism Modulation (Human Supported Via DIM) · Metabolic Regulation

Research maturity: Theoretical / mechanistic research — Mechanistic or unresolved evidence is kept separate from established human outcomes.

Safety boundary: Safety note available — Generally safe with limited long term data | Generally safe; high dose effects unclear

Evidence Strength

Confidence estimate based on the design quality and consistency of published clinical trials.

Needs review

Indole 3 Carbinol has an evidence rating that is still under review.

General wellnessGeneral wellness
Effects
3
How evidence grades work

Each grade reflects the strength and consistency of published human evidence — not marketing claims. Grades are based on study count, design quality, effect size, consistency, and recency.

Strong
Multiple RCTs, consistent direction, adequate effect size
Moderate
Some RCTs or consistent observational data in humans
Preliminary / Mixed
Animal or in-vitro only, or conflicting human data
Traditional / Theoretical
Traditional use only; no controlled human trials

How Indole 3 Carbinol Works

Simplified mechanism pathway based on preclinical and pharmacological evidence. Does not confirm clinical efficacy.

Mechanism Pathway — How Indole 3 Carbinol Works

How Indole 3 Carbinol WorksIndole 3 Carbinol acts on biological target pathways via metabolic (regulation), leading to estrogen receptors.Indole 3 CarbinolBiological TargetBiological pathwayMetabolicRegulationEstrogen ReceptorsObservable outcomeHormonal SignalingContext
CompoundTarget / ReceptorMechanismEffect / Outcome

Dosing

Common form
capsule or standardized extract
No standardized dose
Our source data records the usual product form for this ingredient but no studied dose. Preparations differ widely, so follow the standardization on the product you actually have and speak to a clinician before starting.
Mechanisms & biological pathways

Preclinical mechanism details from scientific profiles; these represent plausible pathways but do not guarantee clinical efficacy in humans.

  • Phase I/II Detoxification Enzyme Regulation (Preclinical)
  • Estrogen Metabolism Modulation (Human Supported Via DIM)
  • Metabolic Regulation
  • Hormonal Signaling Context
  • AhR Pathway Activation (Investigational)

Compare & Sourcing

Compare side-by-side tradeoffs or verify active marker guidelines.

Safety first · Harm reduction

This information is educational and not medical advice. Start low, avoid risky combinations, and consult a licensed clinician before making health decisions—especially if you use medications, have diagnosed conditions, or are pregnant/breastfeeding.

Learn how we evaluate confidence, safety, and intensity on the methodology page.

By Willie B. Randolph III

Founder & Head Researcher · Oak Ridge, TN · Last reviewed August 2026

Editorial Review

Checked against primary sources, cited evidence, and contraindication language before publication. Evidence claims, safety language, and affiliate modules are reviewed independently. Not personal medical advice.

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