Related Compounds
Compounds connected by the same goals, effects, or research topics.
Compound Profile
Pygeum
Pygeum has moderate evidence for modest improvement in BPH urinary symptoms and urinary flow.
Review needed — Mild GI upset possible. Details
Last reviewed: •1 source citedReport a correctionProfile-wide ·B Moderate
At a glance
From this profile's structured data- Evidence
- Grade B
- Safety
- Mild GI upset possible.
- Profile context
- prostate tissue, urinary flow
Quick stats
- Evidence level
- Moderate evidence
- Typical onset
- Varies by prep
- Safety rating
- Review needed: Safety review pending
- Best for
- Prostate Tissue, Urinary Flow
- Avoid / review if
- Sensitive Stomach (Can Cause Nausea Or Abdominal Pain Or Constipation)
Safety
Safety & Cautions
Mild GI upset possible.
Elevated caution
Caution level: Elevated. One caution category applies — read it before use.
- Pregnancy/Breastfeeding CautionPregnancy or breastfeeding caution language is present.
Evidence Summary
Profile-wide ·B ModerateEvidence lens
Useful signal, but study design, dose, and population still matter.
ModerateModerate evidence
Human clinical evidence: Not the primary signal
Mechanistic / preclinical: Mechanism mapped — Inflammatory Signaling Modulation · Oxidative Stress Modulation · Oxidative Stress
Research maturity: Theoretical / mechanistic research — Mechanistic or unresolved evidence is kept separate from established human outcomes.
Safety boundary: Safety note available — Mild GI upset possible.
This profile cites 1 human study.
Evidence Strength
Confidence estimate based on the design quality and consistency of published clinical trials.
Pygeum has a moderate evidence rating.
AdaptogenStress & MoodLongevity
Citation density
0.5
Sources
1
Effects
2
Research recency
Mixed recency
Evidence Grade
Grade B: Moderate Evidence
Evaluation of methodological rigor, population reach, and evidence alignment.
- Design Match
- Systematic review
- Risk of Bias
- Low
- Consistency
- Not assessed
Strongest recorded design is a systematic review, drawn from 1 recorded study, 1 in people.
How evidence grades work
Each grade reflects the strength and consistency of published human evidence — not marketing claims. Grades are based on study count, design quality, effect size, consistency, and recency.
- Strong
- Multiple RCTs, consistent direction, adequate effect size
- Moderate
- Some RCTs or consistent observational data in humans
- Preliminary / Mixed
- Animal or in-vitro only, or conflicting human data
- Traditional / Theoretical
- Traditional use only; no controlled human trials
Clinical Study Summaries (1)0 human evidence sources · 0 human trials · Participant totals not consistently reported · Consistency not yet classifiable
What the evidence actually shows
This table contains 1 structured source, including 0 human evidence sources; 0 are human trials.
| Study | Design | N | Dose | Duration | Population | Outcome | Result & magnitude | Source |
|---|---|---|---|---|---|---|---|---|
PubMed · Int Braz J Urol · 2002 Background | Other / unclear The study design is not yet classified clearly enough to infer its place in the evidence hierarchy. | — | — | — | — | — | — | PubMed → |
How Pygeum Works
Simplified mechanism pathway based on preclinical and pharmacological evidence. Does not confirm clinical efficacy.
Mechanism Pathway — How Pygeum Works
CompoundTarget / ReceptorMechanismEffect / Outcome
Dosing
- Common form
- capsule or standardized extract
- No standardized dose
- Our source data records the usual product form for this ingredient but no studied dose. Preparations differ widely, so follow the standardization on the product you actually have and speak to a clinician before starting.
Mechanisms & biological pathways
Preclinical mechanism details from scientific profiles; these represent plausible pathways but do not guarantee clinical efficacy in humans.
- Inflammatory Signaling Modulation
- Oxidative Stress Modulation
- Oxidative Stress
Guides that use Pygeum
Condition guides
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Compare & Sourcing
Compare side-by-side tradeoffs or verify active marker guidelines.
Related alternatives
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Tradeoffs
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Safety first · Harm reduction
This information is educational and not medical advice. Start low, avoid risky combinations, and consult a licensed clinician before making health decisions—especially if you use medications, have diagnosed conditions, or are pregnant/breastfeeding.
Learn how we evaluate confidence, safety, and intensity on the methodology page.
Editorial Review
Checked against primary sources, cited evidence, and contraindication language before publication. Evidence claims, safety language, and affiliate modules are reviewed independently. Not personal medical advice.
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