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Herb Profile
Coriandrum Sativum
Coriandrum sativum
Coriandrum Sativum (Coriandrum sativum) carries a Grade C rating — limited evidence.
Last reviewed: •3 sources citedReport a correctionProfile-wide ·C Limited
Use extra caution — Culinary use is usually low risk; concentrated extracts may affect glucose or sedation; caution with Apiaceae allergy, diabetes medications, sedatives, pregnancy/breastfeeding, and perioperative use. Details
- Evidence
- Limited Evidence
- Typical onset
- Varies by prep
- Safety rating
- High caution
- Best for
- Sleep, Cognitive function, Metabolic health
- Avoid / review if
- Pregnancy/Breastfeeding Without Clinician Supervision, Known Allergy To The Plant/Family, Seizure Disorder Or Sedative/Alcohol Use
At a glance
From this profile's structured data- Evidence
- Grade C
- Safety
- Culinary use is usually low risk; concentrated extracts may affect glucose or sedation; caution with Apiaceae allergy, diabetes medications, sedatives, pregnancy/breastfeeding, and perioperative use.
- Profile context
- sleep
Next stepsWhere to go next — guides & comparisons
Continue reading
- If you want help sleeping → Sleep guides
- If you want to browse more herbs → All herbs
Safety
Safety & Cautions
Culinary use is usually low risk; concentrated extracts may affect glucose or sedation; caution with Apiaceae allergy, diabetes medications, sedatives, pregnancy/breastfeeding, and perioperative use.
High caution
Caution level: High. Multiple caution categories apply, or the record uses avoid/contraindication language.
- Interaction-AwareMedication or interaction context is explicitly noted.
- Pregnancy/Breastfeeding CautionPregnancy or breastfeeding caution language is present.
Detailed safety fields
Pregnancy, breastfeeding, and contraindications
- Pregnancy/Breastfeeding Without Clinician Supervision
- Known Allergy To The Plant/Family
- Seizure Disorder Or Sedative/Alcohol Use
- Potential Interaction Concern With Antidiabetic Medicines
- Sedatives/CNS Depressants
- Use Clinician Review For High Dose Extracts Or Chronic Use.
Safety classifications
- Interaction-Aware: Medication or interaction context is explicitly noted.
- Pregnancy/Breastfeeding Caution: Pregnancy or breastfeeding caution language is present.
Full safety note
- Culinary use is usually low risk; concentrated extracts may affect glucose or sedation; caution with Apiaceae allergy, diabetes medications, sedatives, pregnancy/breastfeeding, and perioperative use.
Safety labels
- Interaction-Aware
- Pregnancy/Breastfeeding Caution
Evidence-based safety
Caution when combined
Severity and certainty are shown separately. A high-priority caution can still be theoretical: these pairings are screened from shared contraindication mechanisms and are not automatically documented clinical interactions. Provenance identifies the source fields that produced each flag; it does not upgrade the certainty of the pairwise claim.
Moderate Caution
178 flagged pairingsBlood-sugar lowering · Sedation / CNS depression
Moderate Caution
178 flagged pairingsBlood-sugar lowering · Sedation / CNS depression
Representative pairings are shown below. Large mechanism groups are intentionally summarized to keep profiles focused and crawl-efficient.
Blood-sugar loweringCertainty: Theoretical
Data provenance recorded for 110 of 110 pairings in this mechanism group.
- Acarbose — Theoretical interaction certainty
- ajoene — Theoretical interaction certainty
- Allicin — Theoretical interaction certainty
- Aloe Vera — Theoretical interaction certainty
- Alpha-Lipoic Acid — Theoretical interaction certainty
- American Ginseng Extract — Theoretical interaction certainty
- Andrographis — Theoretical interaction certainty
- Anemarrhena Asphodeloides — Theoretical interaction certainty
- Tarragon — Theoretical interaction certainty
- Ashoka — Theoretical interaction certainty
- Astragalus — Theoretical interaction certainty
- Astragalus Membranaceus — Theoretical interaction certainty
+98 more pairings share this mechanism. Use the Safety Checker to review a specific combination.
Sedation / CNS depressionCertainty: Theoretical
Data provenance recorded for 68 of 68 pairings in this mechanism group.
- American Yellow Lotus — Theoretical interaction certainty
- Artemisia Absinthium — Theoretical interaction certainty
- Ashwagandha (Withania somnifera) — Theoretical interaction certainty
- Bacopa — Theoretical interaction certainty
- Black Seed — Theoretical interaction certainty
- Black Tea — Theoretical interaction certainty
- Blue Lotus — Theoretical interaction certainty
- Calamus — Theoretical interaction certainty
- Catuba — Theoretical interaction certainty
- Celastrus Paniculatus — Theoretical interaction certainty
- Chamomile — Theoretical interaction certainty
- Chinese Skullcap — Theoretical interaction certainty
+56 more pairings share this mechanism. Use the Safety Checker to review a specific combination.
Evidence
Evidence Summary
Evidence lens
Read as directional context, not settled clinical proof.
LimitedLimited Evidence
Human clinical evidence: Not the primary signal
Mechanistic / preclinical: Mechanism mapped — Metabolic Regulation · Neurotransmitter Modulation · Nrf2 Activation
Research maturity: Theoretical / mechanistic research — Mechanistic or unresolved evidence is kept separate from established human outcomes.
Safety boundary: Safety note available — Culinary use is usually low risk; concentrated extracts may affect glucose or sedation; caution with Apiaceae allergy, diabetes medications, sedatives, pregnancy/breastfeeding, and perioperative use.
This profile cites 3 human studies.
Study design details
Evidence Grade
Grade C: Limited Evidence
Evaluation of methodological rigor, population reach, and evidence alignment.
- Design Match
- Narrative review
- Risk of Bias
- High
- Consistency
- Not assessed
Strongest recorded design is a narrative review, drawn from 3 recorded studies, none of which measured an outcome in people.
How evidence grades work
Each grade reflects the strength and consistency of published human evidence — not marketing claims. Grades are based on study count, design quality, effect size, consistency, and recency.
- Strong
- Multiple RCTs, consistent direction, adequate effect size
- Moderate
- Some RCTs or consistent observational data in humans
- Preliminary / Mixed
- Animal or in-vitro only, or conflicting human data
- Traditional / Theoretical
- Traditional use only; no controlled human trials
Clinical Study Summaries (3)0 human evidence sources · 0 human trials · Participant totals not consistently reported · Consistency not yet classifiable
What the evidence actually shows
This table contains 3 structured sources, including 0 human evidence sources; 0 are human trials.
| Study | Design | N | Dose | Duration | Population | Outcome | Result & magnitude | Source |
|---|---|---|---|---|---|---|---|---|
Plants Used as Antihypertensive Verma T et al. · Nat Prod Bioprospect · 2021 Background | Narrative review Summarizes selected literature without the full prespecified search and selection methods of a systematic review. | — | — | — | — | — | — | PubMed → |
PubMed indexed authors · 2006 Background | Narrative review Summarizes selected literature without the full prespecified search and selection methods of a systematic review. | — | — | — | — | — | — | PubMed → |
Coriandrum sativum and Its Utility in Psychiatric Disorders Santibáñez A et al. · Molecules · 2023 Background | Narrative review Summarizes selected literature without the full prespecified search and selection methods of a systematic review. | — | — | — | — | — | — | PubMed → |
Dosing & Timing
- No standardized dose
- Preparation specific; use standardized product label for Preparation varies by tradition and product form and require source backed dosage review before therapeutic claims.
How Coriandrum Sativum works
Simplified mechanism pathway based on preclinical and pharmacological evidence. Does not confirm clinical efficacy.
Mechanism Pathway — How Coriandrum Sativum Works
CompoundTarget / ReceptorMechanismEffect / Outcome
Mechanisms & biological pathways (preclinical)
- Metabolic Regulation
- Neurotransmitter Modulation
- Nrf2 Activation
- Glucose Metabolism Support
- Lipid Metabolism Support
Active Compounds
Key constituents studied in Coriandrum Sativum, with full pharmacology and safety profiles.
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Safety first · Harm reduction
This information is educational and not medical advice. Start low, avoid risky combinations, and consult a licensed clinician before making health decisions—especially if you use medications, have diagnosed conditions, or are pregnant/breastfeeding.
Learn how we evaluate confidence, safety, and intensity on the methodology page.
Editorial Review
Checked against primary sources, cited evidence, and contraindication language before publication. Evidence claims, safety language, and affiliate modules are reviewed independently. Not personal medical advice.
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