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Herb Profile
Maitake D Fraction
Grifola frondosa
Maitake D fraction (Grifola frondosa) carries a Grade C rating — limited evidence.
Last reviewed: •3 sources citedReport a correctionProfile-wide ·C Limited
Use extra caution — Immune active mushroom extract; use caution with immunosuppressants, transplant medicines, autoimmune disease, and during active cancer treatment unless clinician supervised. Details
- Evidence
- Limited Evidence
- Typical onset
- Varies by prep
- Safety rating
- High caution
- Best for
- Immune, Inflammatory signaling
- Avoid / review if
- Pregnancy/Breastfeeding Without Clinician Supervision, Known Allergy To The Plant/Family, Potential Interaction Concern With Immunosuppressants
At a glance
From this profile's structured data- Evidence
- Grade C
- Safety
- Immune-active mushroom extract; use caution with immunosuppressants, transplant medicines, autoimmune disease, and during active cancer treatment unless clinician-supervised.
- Profile context
- immune
Next stepsWhere to go next — guides & comparisons
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Safety
Safety & Cautions
Immune active mushroom extract; use caution with immunosuppressants, transplant medicines, autoimmune disease, and during active cancer treatment unless clinician supervised.
High caution
Caution level: High. Multiple caution categories apply, or the record uses avoid/contraindication language.
- Interaction-AwareMedication or interaction context is explicitly noted.
- Pregnancy/Breastfeeding CautionPregnancy or breastfeeding caution language is present.
Detailed safety fields
Pregnancy, breastfeeding, and contraindications
- Pregnancy/Breastfeeding Without Clinician Supervision
- Known Allergy To The Plant/Family
- Potential Interaction Concern With Immunosuppressants
- Use Clinician Review For High Dose Extracts Or Chronic Use.
Safety classifications
- Interaction-Aware: Medication or interaction context is explicitly noted.
- Pregnancy/Breastfeeding Caution: Pregnancy or breastfeeding caution language is present.
Full safety note
- Immune active mushroom extract; use caution with immunosuppressants, transplant medicines, autoimmune disease, and during active cancer treatment unless clinician supervised.
Safety labels
- Interaction-Aware
- Pregnancy/Breastfeeding Caution
Evidence
Evidence Summary
Evidence lens
Read as directional context, not settled clinical proof.
LimitedLimited Evidence
Human clinical evidence: Present in source signals
Mechanistic / preclinical: Mechanism mapped — Inflammatory Signaling Modulation · Immune Signaling Modulation · NF KB Modulation
Research maturity: Emerging research — Long Term Human Evidence May Be Limited.
Safety boundary: Safety note available — Immune active mushroom extract; use caution with immunosuppressants, transplant medicines, autoimmune disease, and during active cancer treatment unless clinician supervised.
This profile cites 3 human studies.
Study design details
Evidence Grade
Grade C: Limited Evidence
Evaluation of methodological rigor, population reach, and evidence alignment.
- Design Match
- Randomized controlled trial
- Risk of Bias
- Low
- Consistency
- Not assessed
Strongest recorded design is a randomized controlled trial, drawn from 2 recorded studies, 2 in people.
How evidence grades work
Each grade reflects the strength and consistency of published human evidence — not marketing claims. Grades are based on study count, design quality, effect size, consistency, and recency.
- Strong
- Multiple RCTs, consistent direction, adequate effect size
- Moderate
- Some RCTs or consistent observational data in humans
- Preliminary / Mixed
- Animal or in-vitro only, or conflicting human data
- Traditional / Theoretical
- Traditional use only; no controlled human trials
Clinical Study Summaries (4)1 human evidence source · 1 human trial · ~141 participants across 1 human evidence source with reported N · Consistency not yet classifiable
Filter by study class
Showing 4 of 4 studies.
What the evidence actually shows
This table contains 4 structured sources, including 1 human evidence source; 1 is a human trial. Across 1 human evidence source with a reported sample size, the approximate participant total is 141; overlapping publications may include some of the same people.
| Study | Design | N | Dose | Duration | Population | Outcome | Result & magnitude | Source |
|---|---|---|---|---|---|---|---|---|
Hu Q et al. · Acta Biochim Pol · 2022 Background | Randomized controlled trial Randomly assigns participants to interventions or controls, reducing many sources of bias when the trial is conducted well. | n=141 | — | — | — | — | — | PubMed → |
Antitumoral and antimetastatic activity of Maitake D-Fraction in triple-negative breast cancer cells Alonso EN et al. · Oncotarget · 2018 Background | Other / unclear The study design is not yet classified clearly enough to infer its place in the evidence hierarchy. | — | — | — | — | — | — | PubMed → |
Soares R et al. · J Med Food · 2011 Background | Other / unclear The study design is not yet classified clearly enough to infer its place in the evidence hierarchy. | — | — | — | — | — | — | PubMed → |
Background | Other / unclear The study design is not yet classified clearly enough to infer its place in the evidence hierarchy. | — | — | — | — | — | A very small human study (10 cancer patients) evaluated Maitake D-fraction and natural-killer-cell activity. The nondefinitive design and tiny sample do not support cancer-treatment efficacy claims. | PubMed → |
Dosing & Timing
- No standardized dose
- Preparation specific; use standardized product label for Preparation varies by tradition and product form and require source backed dosage review before therapeutic claims.
How Maitake D Fraction works
Simplified mechanism pathway based on preclinical and pharmacological evidence. Does not confirm clinical efficacy.
Mechanism Pathway — How Maitake D Fraction Works
CompoundTarget / ReceptorMechanismEffect / Outcome
Mechanisms & biological pathways (preclinical)
- Inflammatory Signaling Modulation
- Immune Signaling Modulation
- NF KB Modulation
Active Compounds
Key constituents studied in Maitake D Fraction, with full pharmacology and safety profiles.
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Compare & Sourcing
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Review available sources for Maitake D Fraction
Independent database mapping — evaluated separately from safety and efficacy scores.
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Safety first · Harm reduction
This information is educational and not medical advice. Start low, avoid risky combinations, and consult a licensed clinician before making health decisions—especially if you use medications, have diagnosed conditions, or are pregnant/breastfeeding.
Learn how we evaluate confidence, safety, and intensity on the methodology page.
Editorial Review
Checked against primary sources, cited evidence, and contraindication language before publication. Evidence claims, safety language, and affiliate modules are reviewed independently. Not personal medical advice.
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