Herb Profile
Nettle Root
Urtica dioica
Nettle Root (Urtica dioica) carries a Grade C rating — limited evidence.
Last reviewed: •3 sources citedReport a correctionProfile-wide ·C Limited
Use extra caution — May affect diuretics, blood pressure, glucose, and anticoagulant therapy; avoid pregnancy at medicinal doses. Details
- Evidence
- Limited Evidence
- Typical onset
- Varies by prep
- Safety rating
- High caution
- Best for
- Anti Inflammatory, Inflammatory signaling, Hormonal effects
Safety
Safety & Cautions
May affect diuretics, blood pressure, glucose, and anticoagulant therapy; avoid pregnancy at medicinal doses.
High caution
Caution level: High. Multiple caution categories apply, or the record uses avoid/contraindication language.
- Interaction-AwareMedication or interaction context is explicitly noted.
- Hormonal Activity ContextHormone-adjacent wording is present and should be interpreted carefully.
Detailed safety fields
Safety classifications
- Interaction-Aware: Medication or interaction context is explicitly noted.
- Hormonal Activity Context: Hormone-adjacent wording is present and should be interpreted carefully.
Full safety note
- May affect diuretics, blood pressure, glucose, and anticoagulant therapy; avoid pregnancy at medicinal doses.
Safety labels
- Interaction-Aware
- Hormonal Activity Context
Evidence-based safety
Caution when combined
Severity and certainty are shown separately. A high-priority caution can still be theoretical: these pairings are screened from shared contraindication mechanisms and are not automatically documented clinical interactions. Provenance identifies the source fields that produced each flag; it does not upgrade the certainty of the pairwise claim.
High-Priority Caution
147 flagged pairingsBleeding / anticoagulant risk
High-Priority Caution
147 flagged pairingsBleeding / anticoagulant risk
Representative pairings are shown below. Large mechanism groups are intentionally summarized to keep profiles focused and crawl-efficient.
Bleeding / anticoagulant riskCertainty: Theoretical
Data provenance recorded for 147 of 147 pairings in this mechanism group.
- aescin — Theoretical interaction certainty
- Aged Garlic Extract — Theoretical interaction certainty
- ajoene — Theoretical interaction certainty
- Ajwain — Theoretical interaction certainty
- Allicin — Theoretical interaction certainty
- Garlic — Theoretical interaction certainty
- American Ginseng Extract — Theoretical interaction certainty
- Andrographis — Theoretical interaction certainty
- Angelica Archangelica — Theoretical interaction certainty
- Angelica Dahurica — Theoretical interaction certainty
- Angelica Pubescens — Theoretical interaction certainty
- Angelica Root — Theoretical interaction certainty
+135 more pairings share this mechanism. Use the Safety Checker to review a specific combination.
Moderate Caution
191 flagged pairingsBlood-sugar lowering · Blood-pressure effects
Moderate Caution
191 flagged pairingsBlood-sugar lowering · Blood-pressure effects
Representative pairings are shown below. Large mechanism groups are intentionally summarized to keep profiles focused and crawl-efficient.
Blood-sugar loweringCertainty: Theoretical
Data provenance recorded for 110 of 110 pairings in this mechanism group.
- Acarbose — Theoretical interaction certainty
- ajoene — Theoretical interaction certainty
- Allicin — Theoretical interaction certainty
- Aloe Vera — Theoretical interaction certainty
- Alpha-Lipoic Acid — Theoretical interaction certainty
- American Ginseng Extract — Theoretical interaction certainty
- Andrographis — Theoretical interaction certainty
- Anemarrhena Asphodeloides — Theoretical interaction certainty
- Tarragon — Theoretical interaction certainty
- Ashoka — Theoretical interaction certainty
- Astragalus — Theoretical interaction certainty
- Astragalus Membranaceus — Theoretical interaction certainty
+98 more pairings share this mechanism. Use the Safety Checker to review a specific combination.
Blood-pressure effectsCertainty: Theoretical
Data provenance recorded for 81 of 81 pairings in this mechanism group.
- Agmatine sulfate — Theoretical interaction certainty
- ajoene — Theoretical interaction certainty
- Allicin — Theoretical interaction certainty
- American Ginseng Extract — Theoretical interaction certainty
- Andrographis — Theoretical interaction certainty
- Angelica Dahurica — Theoretical interaction certainty
- Astaxanthin — Theoretical interaction certainty
- Astragalus Membranaceus — Theoretical interaction certainty
- Beetroot extract — Theoretical interaction certainty
- Berberis — Theoretical interaction certainty
- Bicarbonate — Theoretical interaction certainty
- Black Seed — Theoretical interaction certainty
+69 more pairings share this mechanism. Use the Safety Checker to review a specific combination.
Evidence
Evidence Summary
Evidence lens
Read as directional context, not settled clinical proof.
LimitedLimited Evidence
Human clinical evidence: Present in source signals
Mechanistic / preclinical: Mechanism mapped — Inflammatory Signaling Modulation · Hormonal Signaling Context
Research maturity: Emerging research — Long Term Human Evidence May Be Limited.
Safety boundary: Safety note available — May affect diuretics, blood pressure, glucose, and anticoagulant therapy; avoid pregnancy at medicinal doses.
This profile cites 3 human studies.
Study design details
Evidence Grade
Grade C: Limited Evidence
Evaluation of methodological rigor, population reach, and evidence alignment.
- Design Match
- Randomized controlled trial
- Risk of Bias
- Low
- Consistency
- Not assessed
Strongest recorded design is a randomized controlled trial, drawn from 4 recorded studies, 1 in people.
How evidence grades work
Each grade reflects the strength and consistency of published human evidence — not marketing claims. Grades are based on study count, design quality, effect size, consistency, and recency.
- Strong
- Multiple RCTs, consistent direction, adequate effect size
- Moderate
- Some RCTs or consistent observational data in humans
- Preliminary / Mixed
- Animal or in-vitro only, or conflicting human data
- Traditional / Theoretical
- Traditional use only; no controlled human trials
Clinical Study Summaries (4)1 human evidence source · 1 human trial · Participant totals not consistently reported · Consistency not yet classifiable
Filter by study class
Showing 4 of 4 studies.
What the evidence actually shows
This table contains 4 structured sources, including 1 human evidence source; 1 is a human trial.
| Study | Design | N | Dose | Duration | Population | Outcome | Result & magnitude | Source |
|---|---|---|---|---|---|---|---|---|
Background | Randomized controlled trial Randomly assigns participants to interventions or controls, reducing many sources of bias when the trial is conducted well. | — | — | — | — | — | A large randomized trial (558 completers) reported improvement in lower-urinary-tract/BPH outcomes with Urtica dioica. This is root/BPH evidence and should not be mapped to nettle leaf or general anti-inflammatory claims. | PubMed → |
Treatment of Benign Prostatic Hyperplasia by Natural Drugs Csikós E et al. · Molecules · 2021 Background | Narrative review Summarizes selected literature without the full prespecified search and selection methods of a systematic review. | — | — | — | — | — | — | PubMed → |
Screening of pharmacological uses of Urtica dioica and others benefits Dhouibi R et al. · Prog Biophys Mol Biol · 2020 Background | Narrative review Summarizes selected literature without the full prespecified search and selection methods of a systematic review. | — | — | — | — | — | — | PubMed → |
A comprehensive review on the stinging nettle effect and efficacy profiles. Part II: urticae radix Chrubasik JE et al. · Phytomedicine · 2007 Background | Narrative review Summarizes selected literature without the full prespecified search and selection methods of a systematic review. | — | — | — | — | — | — | PubMed → |
Dosing & Timing
- No standardized dose
- Preparation specific; use standardized product label for Root/rhizome preparations are commonly used as teas and require source backed dosage review before therapeutic claims.
How Nettle Root works
Simplified mechanism pathway based on preclinical and pharmacological evidence. Does not confirm clinical efficacy.
Mechanism Pathway — How Nettle Root Works
CompoundTarget / ReceptorMechanismEffect / Outcome
Mechanisms & biological pathways (preclinical)
- Inflammatory Signaling Modulation
- Hormonal Signaling Context
Active Compounds
Key constituents studied in Nettle Root, with full pharmacology and safety profiles.
Compare related active botanicals
Explore botanicals with similar chemistry, effects, or safety considerations in the Botanical Activity Atlas.
Compare & Sourcing
Compare side-by-side tradeoffs or verify active marker guidelines.
Sourcing options
Nettle Root product picks
Affiliate recommendations for Nettle Root. Review safety, dose, and product quality before buying.
As an Amazon Associate I earn from qualifying purchases. We may earn a commission from qualifying links at no extra cost to you. How we stay independent.
Product form & quality guidelines
When sourcing Nettle Root, verify the label for:
- Standardized extract: Confirm active content percentages on the supplement facts panel (e.g. standardized to specific marker compounds) rather than simple raw herb weights.
- Third-party testing: Look for independent purity labels (USP, NSF, ConsumerLab, or Eurofins) to ensure the product is free from heavy metals, solvents, and contaminants.
- Form bioavailability: Ensure the form matches evidence-supported configurations (e.g. standardized active extracts like bacosides, withanolides, or curcuminoids) for optimal onset and digestion tolerance.
Safety first · Harm reduction
This information is educational and not medical advice. Start low, avoid risky combinations, and consult a licensed clinician before making health decisions—especially if you use medications, have diagnosed conditions, or are pregnant/breastfeeding.
Learn how we evaluate confidence, safety, and intensity on the methodology page.
Founder & Head Researcher · Oak Ridge, TN · Last reviewed August 2026
Editorial Review
Checked against primary sources, cited evidence, and contraindication language before publication. Evidence claims, safety language, and affiliate modules are reviewed independently. Not personal medical advice.
Help improve this profile
Was this useful for your research?
These controls record only the page and the structured choice you make when analytics consent is enabled. Please don’t include personal medical information in research requests.
Was this evidence summary clear?
Did you find what you were researching?
Free safety checklist
Get the Nettle Root research notes
Evidence summaries, dosing context, and safety updates for this herb — straight to your inbox.
We use your email to send the checklist and occasional evidence-first supplement updates. Unsubscribe anytime. Privacy policy.