Herb Profile
Notoginseng
Panax notoginseng
Notoginseng (Panax notoginseng) carries a Grade C rating — limited evidence.
Last reviewed: •3 sources citedReport a correctionProfile-wide ·C Limited
Use extra caution — May affect platelet aggregation and bleeding risk; use caution with anticoagulants/antiplatelets, before surgery, and during pregnancy unless supervised. Details
- Evidence
- Limited Evidence
- Typical onset
- Varies by prep
- Safety rating
- Moderate caution
- Best for
- Cardiovascular, Anti Inflammatory, Metabolic, Inflammatory signaling
- Avoid / review if
- Pregnancy, Anticoagulant/Antiplatelet Use Without Clinician Review, Upcoming Surgery
Safety
Safety & Cautions
May affect platelet aggregation and bleeding risk; use caution with anticoagulants/antiplatelets, before surgery, and during pregnancy unless supervised.
Elevated caution
Caution level: Elevated. One caution category applies — read it before use.
- Anticoagulant CautionBleeding or anticoagulant-adjacent caution language is present.
Detailed safety fields
Pregnancy, breastfeeding, and contraindications
- Pregnancy
- Anticoagulant/Antiplatelet Use Without Clinician Review
- Upcoming Surgery
- May Interact With Anticoagulants
- Antiplatelets
- Antihypertensives
- And Antidiabetics.
Safety classifications
- Anticoagulant Caution: Bleeding or anticoagulant-adjacent caution language is present.
Full safety note
- May affect platelet aggregation and bleeding risk; use caution with anticoagulants/antiplatelets, before surgery, and during pregnancy unless supervised.
Safety labels
- Anticoagulant Caution
Evidence-based safety
Caution when combined
Severity and certainty are shown separately. A high-priority caution can still be theoretical: these pairings are screened from shared contraindication mechanisms and are not automatically documented clinical interactions. Provenance identifies the source fields that produced each flag; it does not upgrade the certainty of the pairwise claim.
High-Priority Caution
147 flagged pairingsBleeding / anticoagulant risk
High-Priority Caution
147 flagged pairingsBleeding / anticoagulant risk
Representative pairings are shown below. Large mechanism groups are intentionally summarized to keep profiles focused and crawl-efficient.
Bleeding / anticoagulant riskCertainty: Theoretical
Data provenance recorded for 147 of 147 pairings in this mechanism group.
- aescin — Theoretical interaction certainty
- Aged Garlic Extract — Theoretical interaction certainty
- ajoene — Theoretical interaction certainty
- Ajwain — Theoretical interaction certainty
- Allicin — Theoretical interaction certainty
- Garlic — Theoretical interaction certainty
- American Ginseng Extract — Theoretical interaction certainty
- Andrographis — Theoretical interaction certainty
- Angelica Archangelica — Theoretical interaction certainty
- Angelica Dahurica — Theoretical interaction certainty
- Angelica Pubescens — Theoretical interaction certainty
- Angelica Root — Theoretical interaction certainty
+135 more pairings share this mechanism. Use the Safety Checker to review a specific combination.
Moderate Caution
191 flagged pairingsBlood-sugar lowering · Blood-pressure effects
Moderate Caution
191 flagged pairingsBlood-sugar lowering · Blood-pressure effects
Representative pairings are shown below. Large mechanism groups are intentionally summarized to keep profiles focused and crawl-efficient.
Blood-sugar loweringCertainty: Theoretical
Data provenance recorded for 110 of 110 pairings in this mechanism group.
- Acarbose — Theoretical interaction certainty
- ajoene — Theoretical interaction certainty
- Allicin — Theoretical interaction certainty
- Aloe Vera — Theoretical interaction certainty
- Alpha-Lipoic Acid — Theoretical interaction certainty
- American Ginseng Extract — Theoretical interaction certainty
- Andrographis — Theoretical interaction certainty
- Anemarrhena Asphodeloides — Theoretical interaction certainty
- Tarragon — Theoretical interaction certainty
- Ashoka — Theoretical interaction certainty
- Astragalus — Theoretical interaction certainty
- Astragalus Membranaceus — Theoretical interaction certainty
+98 more pairings share this mechanism. Use the Safety Checker to review a specific combination.
Blood-pressure effectsCertainty: Theoretical
Data provenance recorded for 81 of 81 pairings in this mechanism group.
- Agmatine sulfate — Theoretical interaction certainty
- ajoene — Theoretical interaction certainty
- Allicin — Theoretical interaction certainty
- American Ginseng Extract — Theoretical interaction certainty
- Andrographis — Theoretical interaction certainty
- Angelica Dahurica — Theoretical interaction certainty
- Astaxanthin — Theoretical interaction certainty
- Astragalus Membranaceus — Theoretical interaction certainty
- Beetroot extract — Theoretical interaction certainty
- Berberis — Theoretical interaction certainty
- Bicarbonate — Theoretical interaction certainty
- Black Seed — Theoretical interaction certainty
+69 more pairings share this mechanism. Use the Safety Checker to review a specific combination.
Evidence
Evidence Summary
Evidence lens
Read as directional context, not settled clinical proof.
LimitedLimited Evidence
Human clinical evidence: Present in source signals
Mechanistic / preclinical: Mechanism mapped — Inflammatory Signaling Modulation · Metabolic Regulation · Vascular Function Support
Research maturity: Emerging research — Long Term Human Evidence May Be Limited.
Safety boundary: Safety note available — May affect platelet aggregation and bleeding risk; use caution with anticoagulants/antiplatelets, before surgery, and during pregnancy unless supervised.
This profile cites 3 human studies.
Study design details
Evidence Grade
Grade C: Limited Evidence
Evaluation of methodological rigor, population reach, and evidence alignment.
- Design Match
- Meta-analysis
- Risk of Bias
- Low
- Consistency
- Not assessed
Strongest recorded design is a meta-analysis, drawn from 3 recorded studies, 2 in people.
How evidence grades work
Each grade reflects the strength and consistency of published human evidence — not marketing claims. Grades are based on study count, design quality, effect size, consistency, and recency.
- Strong
- Multiple RCTs, consistent direction, adequate effect size
- Moderate
- Some RCTs or consistent observational data in humans
- Preliminary / Mixed
- Animal or in-vitro only, or conflicting human data
- Traditional / Theoretical
- Traditional use only; no controlled human trials
Clinical Study Summaries (5)2 human evidence sources · 0 human trials · Participant totals not consistently reported · Consistency not yet classifiable
Filter by study class
Showing 5 of 5 studies.
What the evidence actually shows
This table contains 5 structured sources, including 2 human evidence sources; 0 are human trials.
| Study | Design | N | Dose | Duration | Population | Outcome | Result & magnitude | Source |
|---|---|---|---|---|---|---|---|---|
Background | Meta-analysis Statistically combines results from multiple eligible studies; confidence still depends on the quality, consistency, and directness of those studies. | — | — | — | — | — | A 2025 network meta-analysis of Panax notoginseng saponin interventions for ischemic stroke reported favorable signals across several outcomes, but much of the evidence comes from Chinese trials with variable quality and adjunctive regimens. | PubMed → |
Background | Meta-analysis Statistically combines results from multiple eligible studies; confidence still depends on the quality, consistency, and directness of those studies. | — | — | — | — | — | A 2024 systematic review/meta-analysis of 20 trials (1,856 participants) reported short-term NIHSS and activities-of-daily-living improvements when PNS injections were added after thrombolysis, with no clear adverse-event increase. Crucially, none of the trials reported mortality or disability and certainty ranged from moderate to very low. | PubMed → |
Liu H et al. · Pharmacol Res · 2020 Background | Narrative review Summarizes selected literature without the full prespecified search and selection methods of a systematic review. | — | — | — | — | — | — | PubMed → |
Li S et al. · J Nanobiotechnology · 2023 Background | Other / unclear The study design is not yet classified clearly enough to infer its place in the evidence hierarchy. | — | — | — | — | — | — | PubMed → |
Han J et al. · J Diabetes Res · 2022 Background | Other / unclear The study design is not yet classified clearly enough to infer its place in the evidence hierarchy. | — | — | — | — | — | — | PubMed → |
Dosing & Timing
- No standardized dose
- Preparation specific; use standardized product label for Root powder and require source backed dosage review before therapeutic claims.
How Notoginseng works
Simplified mechanism pathway based on preclinical and pharmacological evidence. Does not confirm clinical efficacy.
Mechanism Pathway — How Notoginseng Works
CompoundTarget / ReceptorMechanismEffect / Outcome
Mechanisms & biological pathways (preclinical)
- Inflammatory Signaling Modulation
- Metabolic Regulation
- Vascular Function Support
Compare related active botanicals
Explore botanicals with similar chemistry, effects, or safety considerations in the Botanical Activity Atlas.
Compare & Sourcing
Compare side-by-side tradeoffs or verify active marker guidelines.
Review available sources for Notoginseng
Independent database mapping — evaluated separately from safety and efficacy scores.
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Safety first · Harm reduction
This information is educational and not medical advice. Start low, avoid risky combinations, and consult a licensed clinician before making health decisions—especially if you use medications, have diagnosed conditions, or are pregnant/breastfeeding.
Learn how we evaluate confidence, safety, and intensity on the methodology page.
Founder & Head Researcher · Oak Ridge, TN · Last reviewed August 2026
Editorial Review
Checked against primary sources, cited evidence, and contraindication language before publication. Evidence claims, safety language, and affiliate modules are reviewed independently. Not personal medical advice.
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