Herb Profile
Psoralea Corylifolia
Psoralea corylifolia
Psoralea Corylifolia (Psoralea corylifolia) carries a Grade C rating — limited evidence.
Last reviewed: •3 sources citedReport a correctionProfile-wide ·C Limited
Use extra caution — High caution: photosensitivity, burns, hepatotoxicity reports, and interaction risks. Details
- Evidence
- Limited Evidence
- Typical onset
- Varies by prep
- Safety rating
- High caution
- Best for
- Bone Health, Skin Support, Anti Inflammatory, Stress
- Avoid / review if
- Pregnancy/Breastfeeding, Liver Disease, Photosensitivity Disorders
Safety
Safety & Cautions
High caution: photosensitivity, burns, hepatotoxicity reports, and interaction risks. Avoid unsupervised internal use or UV exposure after use.
High caution
Caution level: High. Multiple caution categories apply, or the record uses avoid/contraindication language.
- Interaction-AwareMedication or interaction context is explicitly noted.
- Liver-SensitiveLiver-related caution language appears in the profile.
- Hormonal Activity ContextHormone-adjacent wording is present and should be interpreted carefully.
- Pregnancy/Breastfeeding CautionPregnancy or breastfeeding caution language is present.
Detailed safety fields
Pregnancy, breastfeeding, and contraindications
- Pregnancy/Breastfeeding
- Liver Disease
- Photosensitivity Disorders
- Melanoma/Skin Cancer Risk
- And Concurrent Phototherapy Unless Supervised.
- Avoid With Photosensitizing Drugs
- Hepatotoxic Drugs
- Anticoagulants
- And Hormone Active Therapies Unless Supervised.
Safety classifications
- Interaction-Aware: Medication or interaction context is explicitly noted.
- Liver-Sensitive: Liver-related caution language appears in the profile.
- Hormonal Activity Context: Hormone-adjacent wording is present and should be interpreted carefully.
- Pregnancy/Breastfeeding Caution: Pregnancy or breastfeeding caution language is present.
Full safety note
- High caution: photosensitivity, burns, hepatotoxicity reports, and interaction risks. Avoid unsupervised internal use or UV exposure after use.
Safety labels
- Interaction-Aware
- Liver-Sensitive
- Hormonal Activity Context
- Pregnancy/Breastfeeding Caution
Evidence-based safety
Caution when combined
Severity and certainty are shown separately. A high-priority caution can still be theoretical: these pairings are screened from shared contraindication mechanisms and are not automatically documented clinical interactions. Provenance identifies the source fields that produced each flag; it does not upgrade the certainty of the pairwise claim.
High-Priority Caution
147 flagged pairingsBleeding / anticoagulant risk
High-Priority Caution
147 flagged pairingsBleeding / anticoagulant risk
Representative pairings are shown below. Large mechanism groups are intentionally summarized to keep profiles focused and crawl-efficient.
Bleeding / anticoagulant riskCertainty: Theoretical
Data provenance recorded for 147 of 147 pairings in this mechanism group.
- aescin — Theoretical interaction certainty
- Aged Garlic Extract — Theoretical interaction certainty
- ajoene — Theoretical interaction certainty
- Ajwain — Theoretical interaction certainty
- Allicin — Theoretical interaction certainty
- Garlic — Theoretical interaction certainty
- American Ginseng Extract — Theoretical interaction certainty
- Andrographis — Theoretical interaction certainty
- Angelica Archangelica — Theoretical interaction certainty
- Angelica Dahurica — Theoretical interaction certainty
- Angelica Pubescens — Theoretical interaction certainty
- Angelica Root — Theoretical interaction certainty
+135 more pairings share this mechanism. Use the Safety Checker to review a specific combination.
Evidence
Evidence Summary
Evidence lens
Read as directional context, not settled clinical proof.
LimitedLimited Evidence
Human clinical evidence: Present in source signals
Mechanistic / preclinical: Mechanism mapped — Inflammatory Signaling Modulation · Oxidative Stress Modulation · Metabolic Regulation
Research maturity: Emerging research — Long Term Human Evidence May Be Limited.
Safety boundary: Safety note available — High caution: photosensitivity, burns, hepatotoxicity reports, and interaction risks.
This profile cites 3 human studies.
Study design details
Evidence Grade
Grade C: Limited Evidence
Evaluation of methodological rigor, population reach, and evidence alignment.
- Design Match
- Systematic review
- Risk of Bias
- Low
- Consistency
- Not assessed
Strongest recorded design is a systematic review, drawn from 2 recorded studies, 1 in people.
How evidence grades work
Each grade reflects the strength and consistency of published human evidence — not marketing claims. Grades are based on study count, design quality, effect size, consistency, and recency.
- Strong
- Multiple RCTs, consistent direction, adequate effect size
- Moderate
- Some RCTs or consistent observational data in humans
- Preliminary / Mixed
- Animal or in-vitro only, or conflicting human data
- Traditional / Theoretical
- Traditional use only; no controlled human trials
Clinical Study Summaries (3)1 human evidence source · 0 human trials · Participant totals not consistently reported · Consistency not yet classifiable
Filter by study class
Showing 3 of 3 studies.
What the evidence actually shows
This table contains 3 structured sources, including 1 human evidence source; 0 are human trials.
| Study | Design | N | Dose | Duration | Population | Outcome | Result & magnitude | Source |
|---|---|---|---|---|---|---|---|---|
Applications of bakuchiol in dermatology: Systematic review of the literature Puyana C et al. · J Cosmet Dermatol · 2022 Background | Systematic review Uses a predefined method to find and evaluate relevant studies, but may or may not pool their results statistically. | — | — | — | — | — | — | PubMed → |
Kuete V et al. · Chin J Integr Med · 2012 Background | Narrative review Summarizes selected literature without the full prespecified search and selection methods of a systematic review. | — | — | — | — | — | — | PubMed → |
Chaudhuri RK et al. · Int J Cosmet Sci · 2014 Background | Other / unclear The study design is not yet classified clearly enough to infer its place in the evidence hierarchy. | — | — | — | — | — | — | PubMed → |
Dosing & Timing
- No standardized dose
- Preparation specific; use standardized product label for Therapeutic use requires controlled dosing and light exposure management and require source backed dosage review before therapeutic claims.
How Psoralea Corylifolia works
Simplified mechanism pathway based on preclinical and pharmacological evidence. Does not confirm clinical efficacy.
Mechanism Pathway — How Psoralea Corylifolia Works
CompoundTarget / ReceptorMechanismEffect / Outcome
Mechanisms & biological pathways (preclinical)
- Inflammatory Signaling Modulation
- Oxidative Stress Modulation
- Metabolic Regulation
- Hormonal Signaling Context
- Stress Response Modulation
Active Compounds
Key constituents studied in Psoralea Corylifolia, with full pharmacology and safety profiles.
Compare related active botanicals
Explore botanicals with similar chemistry, effects, or safety considerations in the Botanical Activity Atlas.
Compare & Sourcing
Compare side-by-side tradeoffs or verify active marker guidelines.
Sourcing options disabled for safety
Direct product recommendations and affiliate links are suppressed for this herb due to its high caution or needs-review safety classification.
Evaluate the safety checks, contraindications, and potential medication interactions above under clinician supervision before use.
Safety first · Harm reduction
This information is educational and not medical advice. Start low, avoid risky combinations, and consult a licensed clinician before making health decisions—especially if you use medications, have diagnosed conditions, or are pregnant/breastfeeding.
Learn how we evaluate confidence, safety, and intensity on the methodology page.
Founder & Head Researcher · Oak Ridge, TN · Last reviewed August 2026
Editorial Review
Checked against primary sources, cited evidence, and contraindication language before publication. Evidence claims, safety language, and affiliate modules are reviewed independently. Not personal medical advice.
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