Herb Profile
Psoralea Corylifolia
Botanical profile with evidence, safety, and practical fit.
Last reviewed: •3 human studies cited
C PreliminaryUse extra caution — High caution: photosensitivity, burns, hepatotoxicity reports, and interaction risks. Details
- Evidence
- Limited Human Evidence
- Typical onset
- Varies by prep
- Safety rating
- High caution
- Best for
- Bone Health, Skin Support, Anti Inflammatory, Stress
- Avoid / review if
- Pregnancy/Breastfeeding, Liver Disease, Photosensitivity Disorders
Monograph visual
Psoralea Corylifolia
Generated profile category visual
Where to go next — guides & comparisons
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Safety & Cautions
High caution: photosensitivity, burns, hepatotoxicity reports, and interaction risks. Avoid unsupervised internal use or UV exposure after use.
28%
High caution — review carefully
Detailed safety fields
Pregnancy, breastfeeding, and contraindications
- - Pregnancy/Breastfeeding
- - Liver Disease
- - Photosensitivity Disorders
- - Melanoma/Skin Cancer Risk
- - And Concurrent Phototherapy Unless Supervised.
- - Avoid With Photosensitizing Drugs
- - Hepatotoxic Drugs
- - Anticoagulants
- - And Hormone Active Therapies Unless Supervised.
Safety classifications
- - Interaction-Aware: Medication or interaction context is explicitly noted.
- - Liver-Sensitive: Liver-related caution language appears in the profile.
- - Hormonal Activity Context: Hormone-adjacent wording is present and should be interpreted carefully.
- - Pregnancy/Breastfeeding Caution: Pregnancy or breastfeeding caution language is present.
Full safety note
- - High caution: photosensitivity, burns, hepatotoxicity reports, and interaction risks. Avoid unsupervised internal use or UV exposure after use.
Safety labels
- - Interaction-Aware
- - Liver-Sensitive
- - Hormonal Activity Context
- - Pregnancy/Breastfeeding Caution
Evidence-based safety
Caution when combined
These pairings share a flagged risk mechanism. They are additive-effect cautions derived from contraindication data, not confirmed clinical interactions. Consult a clinician before combining.
High-Priority Caution
147 flagged pairingsBleeding / anticoagulant risk
High-Priority Caution
147 flagged pairingsBleeding / anticoagulant risk
Browse the grouped cautions below. The list scrolls inside this card when long.
Bleeding / anticoagulant risk
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- Angelica Pubescens
- Angelica Root
- Angelica Sinensis
- Arjuna
- Artemisia Capillaris
- Artichoke
- Ashitaba
- Ashitaba Extract
- Astaxanthin
- Berberis
- Black Seed
- Black Seed Oil
- Blueberry
- Boldo
- Boswellia
- Capsicum
- Caraway
- Carnitine L Tartrate
- Cayenne
- Chamomile
- Chinese Skullcap
- Chuanxiong
- Cissus
- Citicoline
- Clove
- Cnidium Monnieri
- Coleus Forskohlii
- Commiphora Mukul
- Coenzyme Q10
- Cordyceps
- Cranberry (Vaccinium macrocarpon)
- crocetin
- crocin
- cryptotanshinone
- Curcuma Wenyujin
- Curcumin
- Damiana
- Danshen
- Devils Claw Extract
- Dong Quai
- EGCG
- Epimedium
- Epimedium Brevicornum
- Evening Primrose (Oenothera biennis)
- Fenugreek
- Fenugreek Extract
- ferulic acid
- Feverfew
- Fisetin
- forskolin
- Fraxinus Rhynchophylla
- Fucoxanthin
- Galangal
- Reishi
- Garcinia Mangostana
- Garlic (Allium sativum)
- Garlic Aged Extract
- Garlic Extract
- Ginger (Zingiber officinale)
- Ginkgo
- Ginkgo Biloba Extract
- Ginkgo Extract EGb 761
- Panax Red Ginseng
- Panax White Ginseng
- ginsenoside rg3
- Glucosamine
- Goldenseal
- Lion's Mane
- Holy Basil / Tulsi (Ocimum tenuiflorum)
- Horse Chestnut
- hydroxytyrosol
- Japanese Knotweed
- Kudzu
- L-Carnitine
- Ligusticum Chuanxiong
- Magnolia
- Mangosteen
- Maral Root
- Chamomile
- Melatonin
- MSM
- Myrtle
- Nettle Root
- Nigella Sativa
- Noni
- Notoginseng
- Ocimum Basilicum
- Olive Leaf Extract
- Oregano
- Paeonia Lactiflora
- Asian Ginseng
- Panax Ginseng Extract
- Papaya Leaf
- Pastinaca Sativa
- Pau D'arco
- Perilla
- Phosphatidylserine
- Piper Longum
- Bifidobacterium Probiotic
- Lactobacillus Probiotic
- Probiotics - Bifidobacterium spp.
- Probiotics - Lactobacillus spp.
- Pycnogenol
- Quercetin
- Quercetin Phytosome
- Red Clover
- Reishi (Ganoderma lucidum)
- Resveratrol
- Rhodiola Extract SHR-5
- Rose Hips
- Rosemary
- Saffron
- Saffron Extract
- Salvia miltiorrhiza
- Saw Palmetto (Serenoa repens)
- Saw Palmetto Extract
- Schisandra Berry
- Schisandra Chinensis
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- Selaginella Tamariscina
- Soybean
- Syzygium Aromaticum
- Terminalia arjuna
- Thunder God Vine
- Thyme
- Tongkat Ali
- Trans-Resveratrol
- Fenugreek
- Tripterygium Wilfordii
- Turmeric (Curcuma longa)
- Turmeric Curcumin + Piperine
- Valerian
- Vitamin D3 + K2
- Grape
- White Peony
- Willow Bark Extract
- Yarrow
Evidence Summary
Evidence lens
Early signal that needs stronger human replication before practical claims.
PreliminaryLimited Human Evidence
Human clinical evidence: Present in source signals
Mechanistic / preclinical: Mechanism mapped — Inflammatory Signaling Modulation · Oxidative Stress Modulation · Metabolic Regulation
Research maturity: Preliminary or mixed — Long Term Human Evidence May Be Limited.
Safety boundary: Safety note available — High caution: photosensitivity, burns, hepatotoxicity reports, and interaction risks.
This profile cites 3 human studies.
How evidence grades work
Each grade reflects the strength and consistency of published human evidence — not marketing claims. Grades are based on study count, design quality, effect size, consistency, and recency.
A
Strong
Multiple RCTs, consistent direction, adequate effect size
B
Moderate
Some RCTs or consistent observational data in humans
C
Preliminary / Mixed
Animal or in-vitro only, or conflicting human data
D
Traditional / Theoretical
Traditional use only; no controlled human trials
Clinical Study Summaries (3)Cited studies informing this profile. RCTs and reviews shown first.
| Study | Type | Sample | Source |
|---|---|---|---|
Applications of bakuchiol in dermatology: Systematic review of the literature Puyana C et al. (2022) | — | — | PubMed → |
Chaudhuri RK et al. (2014) | — | — | PubMed → |
Kuete V et al. (2012) | — | — | PubMed → |
Dosing & Timing
Dose guidance
Preparation specific; use standardized product label for Therapeutic use requires controlled dosing and light exposure management and require source backed dosage review before therapeutic claims.
How Psoralea Corylifolia Works
Simplified mechanism pathway based on preclinical and pharmacological evidence. Does not confirm clinical efficacy.
Mechanism Pathway — How Psoralea Corylifolia Works
CompoundTarget / ReceptorMechanismEffect / Outcome
Mechanisms & Biological Pathways
Preclinical pathways
Proposed mechanisms from in vitro and animal research; these do not confirm clinical outcomes in humans.
Inflammatory Signaling ModulationOxidative Stress ModulationMetabolic RegulationHormonal Signaling ContextStress Response Modulation
Active Compounds
Key constituents studied in Psoralea Corylifolia, with full pharmacology and safety profiles.
Condition guides
Compare & Sourcing
Compare side-by-side tradeoffs or verify active marker guidelines.
⚠️ Sourcing Options Disabled for Safety
Direct product recommendations and affiliate links are suppressed for this herb due to its high caution or needs-review safety classification.
Evaluate the safety checks, contraindications, and potential medication interactions below under clinician supervision before use.
Safety first · Harm reduction
This information is educational and not medical advice. Start low, avoid risky combinations, and consult a licensed clinician before making health decisions—especially if you use medications, have diagnosed conditions, or are pregnant/breastfeeding.
Learn how we evaluate confidence, safety, and intensity on the methodology page.
Editorial Review
Checked against primary sources, cited evidence, and contraindication language before publication. Evidence claims, safety language, and affiliate modules are reviewed independently. Not personal medical advice.
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Botanical profile context
How to interpret Psoralea Corylifolia
Psoralea Corylifolia dosage ranges, effects, drug interactions, and harm-reduction safety guide for bone health. Limited Human Evidence research evidence. Use this herb profile as a starting point for evidence review, not as a recommendation to start a new supplement. Botanical products can vary by plant part, extract ratio, standardization, dose, and contaminant testing, so two labels with the same common name may not behave the same way.
When reviewing Psoralea Corylifolia, compare the traditional-use context against the human evidence, mechanism notes, and safety cautions. Pay special attention to pregnancy, breastfeeding, liver or kidney disease, blood-pressure effects, sedation, stimulation, anticoagulant use, antidepressants, and any prescription medication overlap.
For product decisions, prefer transparent labels, named extracts, clear serving sizes, and third-party quality testing. Avoid treating a long list of possible mechanisms as proof that an herb will solve a specific condition.