Medication Safety Guide
This page gathers botanicals whose structured safety data contains serotonergic, SSRI, SNRI, MAOI, or monoamine-oxidase interaction language. It is designed as a screening aid, not a personalized interaction checker.
Do not start, stop, or combine a serotonergic botanical with antidepressants, stimulants, migraine medicines, or other psychoactive drugs based only on this page. A pharmacist or prescriber should review the full combination.
11 of 11 botanicals shown
Relationship graph
Mechanisms are shown as mechanistic context, not as proof of a clinical outcome. Outcome nodes use explicit effect data when available.
Panax ginseng
Human evidence
Not counted
Chemistry
Glycosides
Effects
Cognition / focusMetabolicMechanisms · not outcomes
Metabolic Regulation · Neuroprotective Activity · Glucose Metabolism Support
Safety signals
Stimulation · Bleeding · Serotonergic
Crocus sativus
Human evidence
Not counted
Chemistry
Not mapped
Effects
MoodCognition / focusCalmingInflammation · pathwayMechanisms · not outcomes
Inflammatory Signaling Modulation · Oxidative Stress Modulation · Neurotransmitter Modulation
Safety signals
Serotonergic · Cardiovascular · Dependence / withdrawal
Turnera diffusa
Human evidence
Not counted
Chemistry
Not mapped
Effects
Hormonal / reproductiveMoodnervous_systemCalmingMechanisms · not outcomes
Stress Response Modulation · dopaminergic · HPA-axis modulation
Safety signals
Pregnancy / breastfeeding · Seizure · planned surgery or complex psychiatric medication regimens.
Ginkgo biloba
Human evidence
Not counted
Chemistry
Flavonoids
Effects
Cognition / focusCardiovascularneuroprotectiveMechanisms · not outcomes
Vascular Function Support · Neuroprotective Activity · Vascular function support
Safety signals
Bleeding · Serotonergic · or NSAIDs (aspirin
Mesembryanthemum tortuosum
Human evidence
Not counted
Chemistry
Alkaloids
Effects
Moodanti_anxietyempathogenCalmingMechanisms · not outcomes
Neurotransmitter Modulation · Stress Response Modulation · serotonergic
Safety signals
Pregnancy / breastfeeding · bipolar/mania risk · Serotonergic
Mucuna pruriens
Human evidence
Not counted
Chemistry
Not mapped
Effects
dopamine_supportneuroprotectiveHormonal / reproductiveCalmingMechanisms · not outcomes
Oxidative Stress Modulation · Mitochondrial Support · Neurotransmitter Modulation
Safety signals
Psychosis/bipolar risk · melanoma history caution · Pregnancy / breastfeeding
Passiflora incarnata
Human evidence
1 mapped studies
Chemistry
Not mapped
Effects
Sedating / sleepCalmingMechanisms · not outcomes
Neurotransmitter Modulation · Stress Response Modulation · Neurotransmitter Signaling
Safety signals
Sedation · Serotonergic · Stimulation
Rhodiola rosea
Human evidence
3 mapped studies
Chemistry
Not mapped
Effects
adaptogenCalmingStimulating / energyMetabolic · pathwayMechanisms · not outcomes
Neurotransmitter Modulation · Stress Response Modulation · AMPK Signaling
Safety signals
Stimulation · bipolar/mania vulnerability · Serotonergic
Crocus sativus
Human evidence
1 mapped studies
Chemistry
Not mapped
Effects
Moodanti_anxietyCalmingInflammation · pathwayMechanisms · not outcomes
Inflammatory Signaling Modulation · Oxidative Stress Modulation · Neurotransmitter Modulation
Safety signals
Pregnancy / breastfeeding · known allergy to the plant/family · Serotonergic
Hypericum perforatum
Human evidence
Not counted
Chemistry
Flavonoids
Effects
MoodnervineCalmingStimulating / energy · pathwayMechanisms · not outcomes
Neurotransmitter Modulation · Stress Response Modulation · serotonergic
Safety signals
Pregnancy / breastfeeding · bipolar disorder · Drug metabolism
Pausinystalia johimbe
Human evidence
Not counted
Chemistry
Not mapped
Effects
Sedating / sleepCalmingMechanisms · not outcomes
Neurotransmitter Modulation · Stress Response Modulation · cardiovascular
Safety signals
Cardiovascular · Stimulation · bipolar disorder/mania
| Botanical | Constituent chemistry | Mechanisms · not outcomes | Outcome / effect profile | Noticeability | Safety signals | Timing | ||
|---|---|---|---|---|---|---|---|---|
| Asian Ginseng Panax ginseng | Ginsenoside RB1, Ginsenoside RG1, Ginsenoside Rg3, ginsenosides Glycosides Asian Ginseng contains_compound Ginsenoside RB1 · Asian Ginseng contains_compound Ginsenoside RG1 | Metabolic Regulation · Neuroprotective Activity · Glucose Metabolism Support · Glucose Metabolism | Cognition / focusMetabolic | Unknown | Preliminary | — | Stimulation · Bleeding · Serotonergic · Drug metabolism | Not established |
| Crocus Sativus Crocus sativus | Crocetin, Crocin Crocus Sativus contains_compound Crocetin · Crocus Sativus contains_compound Crocin | Inflammatory Signaling Modulation · Oxidative Stress Modulation · Neurotransmitter Modulation · Stress Response Modulation | MoodCognition / focusCalmingInflammation · pathway | Unknown | Preliminary | — | Serotonergic · Cardiovascular · Dependence / withdrawal · Stimulation | Not established |
| Damiana Turnera diffusa | Not yet mapped | Stress Response Modulation · dopaminergic · HPA-axis modulation · Dopamine modulation | Hormonal / reproductiveMoodnervous_systemCalmingStimulating / energy · pathway | Unknown | Preliminary | — | Pregnancy / breastfeeding · Seizure · planned surgery or complex psychiatric medication regimens. · Sedation | Not established |
| Ginkgo Ginkgo biloba | bilobetin, Ginkgolide B, Ginkgolides, Kaempferol Flavonoids Ginkgo contains_compound bilobetin · Ginkgo contains_compound Ginkgolide B | Vascular Function Support · Neuroprotective Activity · Vascular function support · Neuroprotective activity | Cognition / focusCardiovascularneuroprotective | Unknown | Moderate | — | Bleeding · Serotonergic · or NSAIDs (aspirin · clopidogrel) | Not established |
| Kanna Mesembryanthemum tortuosum | mesembrenone, mesembrine Alkaloids Kanna contains_compound mesembrenone · Kanna contains_compound mesembrine | Neurotransmitter Modulation · Stress Response Modulation · serotonergic · Neurotransmitter modulation | Moodanti_anxietyempathogenCalming | Unknown | Preliminary | — | Pregnancy / breastfeeding · bipolar/mania risk · Serotonergic · active psychiatric medication use without clinician oversight. | Not established |
| Mucuna Mucuna pruriens | Not yet mapped | Oxidative Stress Modulation · Mitochondrial Support · Neurotransmitter Modulation · Stress Response Modulation | dopamine_supportneuroprotectiveHormonal / reproductiveCalming | Unknown | Preliminary | — | Psychosis/bipolar risk · melanoma history caution · Pregnancy / breastfeeding · use with levodopa drugs without clinician supervision | Not established |
| Passionflower Passiflora incarnata | Not yet mapped | Neurotransmitter Modulation · Stress Response Modulation · Neurotransmitter Signaling · Neurotransmitter modulation | Sedating / sleepCalming | Unknown | Moderate | 1 | Sedation · Serotonergic · Stimulation | Not established |
| Rhodiola Rhodiola rosea | Rosarin, Rosavin, Rosin, Salidroside Rhodiola contains_compound Rosarin · Rhodiola contains_compound Rosavin | Neurotransmitter Modulation · Stress Response Modulation · AMPK Signaling · AMPK | adaptogenCalmingStimulating / energyMetabolic · pathway | Unknown | Preliminary | 3 | Stimulation · bipolar/mania vulnerability · Serotonergic · cardiovascular conditions | Not established |
| Saffron Crocus sativus | Crocetin, Crocin, safranal Saffron contains_compound Crocetin · Saffron contains_compound Crocin | Inflammatory Signaling Modulation · Oxidative Stress Modulation · Neurotransmitter Modulation · Stress Response Modulation | Moodanti_anxietyCalmingInflammation · pathway | Unknown | Preliminary | 1 | Pregnancy / breastfeeding · known allergy to the plant/family · Serotonergic · Bleeding | Not established |
| St. John's Wort (Hypericum perforatum) Hypericum perforatum | Hyperforin, Hypericin, Kaempferol, Quercetin Flavonoids St. John's Wort (Hypericum perforatum) contains_compound Hyperforin · St. John's Wort (Hypericum perforatum) contains_compound Hypericin | Neurotransmitter Modulation · Stress Response Modulation · serotonergic · dopaminergic | MoodnervineCalmingStimulating / energy · pathway | Unknown | Unclassified | — | Pregnancy / breastfeeding · bipolar disorder · Drug metabolism · reduces effectiveness of many medications | Not established |
| Yohimbe Pausinystalia johimbe | Not yet mapped | Neurotransmitter Modulation · Stress Response Modulation · cardiovascular · Neurotransmitter modulation | Sedating / sleepCalming | Unknown | Preliminary | — | Cardiovascular · Stimulation · bipolar disorder/mania · Liver | Not established |
Active Chemistry Guide
Compare botanicals containing alkaloid-class constituents by effects, evidence, noticeability, timing, and safety signals.
Effect-Based Guide
Compare stimulating and energy-associated botanicals by active chemistry, evidence, noticeability, timing, and cardiovascular safety signals.
Effect-Based Guide
Compare calming and relaxation-associated botanicals by evidence, noticeability, active chemistry, timing, and sedation risks.
Perception & Dream Guide
Compare botanicals associated with dreams, lucid dreaming, perception changes, or psychoactive effects by evidence and safety.
Educational use only
These comparisons summarize normalized reference data. They do not verify a commercial product, establish a dose, diagnose a condition, or determine whether a botanical is safe for an individual.