Compound Profile
Caffeic Acid
Phenolic acid broadly present in herbs and coffee, commonly linked to NF κB and MAPK signaling.
Last reviewed: Report a correctionProfile-wide ·C Limited
Review needed — Mostly food associated; concentrated extracts may cause GI effects or interact with anticoagulants/antidiabetics depending matrix. Details
- Evidence
- Limited evidence
- Typical onset
- Varies by prep
- Safety rating
- Review needed: Safety review pending
- Best for
- Nrf2, NF κB, Antioxidant Response
Safety
Safety & Cautions
Mostly food associated; concentrated extracts may cause GI effects or interact with anticoagulants/antidiabetics depending matrix.
Standard caution
Caution level: Standard. No specific caution categories were detected in the source record.
Evidence Summary
Profile-wide ·C LimitedEvidence lens
Read as directional context, not settled clinical proof.
LimitedLimited evidence
Human clinical evidence: Not the primary signal
Mechanistic / preclinical: Mechanism mapped — Inflammatory Signaling Modulation · Oxidative Stress Modulation · Mitochondrial Support
Research maturity: Theoretical / mechanistic research — Mechanistic or unresolved evidence is kept separate from established human outcomes.
Safety boundary: Safety note available — Mostly food associated; concentrated extracts may cause GI effects or interact with anticoagulants/antidiabetics depending matrix.
Evidence Strength
Confidence estimate based on the design quality and consistency of published clinical trials.
Caffeic Acid has a limited evidence rating.
AdaptogenStress & MoodLongevity
Effects
5
Evidence Grade
Grade C: Limited Evidence
Evaluation of methodological rigor, population reach, and evidence alignment.
- Design Match
- Meta analysis
- Risk of Bias
- Low
- Consistency
- Not assessed
Strongest recorded design is a meta analysis, drawn from 1 recorded study, 1 in people.
How evidence grades work
Each grade reflects the strength and consistency of published human evidence — not marketing claims. Grades are based on study count, design quality, effect size, consistency, and recency.
- Strong
- Multiple RCTs, consistent direction, adequate effect size
- Moderate
- Some RCTs or consistent observational data in humans
- Preliminary / Mixed
- Animal or in-vitro only, or conflicting human data
- Traditional / Theoretical
- Traditional use only; no controlled human trials
How Caffeic Acid Works
Simplified mechanism pathway based on preclinical and pharmacological evidence. Does not confirm clinical efficacy.
Mechanism Pathway — How Caffeic Acid Works
CompoundTarget / ReceptorMechanismEffect / Outcome
Dosing
- Common form
- standardized extract capsule
- No standardized dose
- Our source data records the usual product form for this ingredient but no studied dose. Preparations differ widely, so follow the standardization on the product you actually have and speak to a clinician before starting.
Mechanisms & biological pathways
Preclinical mechanism details from scientific profiles; these represent plausible pathways but do not guarantee clinical efficacy in humans.
- Inflammatory Signaling Modulation
- Oxidative Stress Modulation
- Mitochondrial Support
- Metabolic Regulation
- NF KB Modulation
- Nrf2 Activation
Botanical Context
Source botanicals and comparison guides related to Caffeic Acid.
Found in
Compare active botanicals
Compare & Sourcing
Compare side-by-side tradeoffs or verify active marker guidelines.
Safety first · Harm reduction
This information is educational and not medical advice. Start low, avoid risky combinations, and consult a licensed clinician before making health decisions—especially if you use medications, have diagnosed conditions, or are pregnant/breastfeeding.
Learn how we evaluate confidence, safety, and intensity on the methodology page.
Founder & Head Researcher · Oak Ridge, TN · Last reviewed August 2026
Editorial Review
Checked against primary sources, cited evidence, and contraindication language before publication. Evidence claims, safety language, and affiliate modules are reviewed independently. Not personal medical advice.
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