Compound Profile

Ferulic Acid

Phenolic acid common in grains and Angelica related herbs, linked to Nrf2 and PI3K/Akt signaling.

Last reviewed: •1 source citedReport a correctionProfile-wide ·C Limited

Review needed — Mostly food associated; concentrated extracts may cause GI effects or interact with anticoagulants/antidiabetics depending matrix. Details

Evidence
Limited evidence
Typical onset
Varies by prep
Safety rating
Review needed: Safety review pending
Best for
Nrf2, NF κB, Antioxidant Response
Avoid / review if
Anticoagulant Or Antiplatelet Medications (May Have Antiplatelet Activity Warranting Caution), Scheduled Surgery (Discontinue Beforehand Due To Theoretical Bleeding Risk), Antihypertensive Medications (Possible Additive Blood Pressure Lowering Effect)
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Ferulic Acid monograph visual
Generated profile category visual

Safety

Safety & Cautions

Mostly food associated; concentrated extracts may cause GI effects or interact with anticoagulants/antidiabetics depending matrix.

High caution

Caution level: High. Multiple caution categories apply, or the record uses avoid/contraindication language.

  • Anticoagulant CautionBleeding or anticoagulant-adjacent caution language is present.
  • Pregnancy/Breastfeeding CautionPregnancy or breastfeeding caution language is present.

Evidence-based safety

Caution when combined

Severity and certainty are shown separately. A high-priority caution can still be theoretical: these pairings are screened from shared contraindication mechanisms and are not automatically documented clinical interactions. Provenance identifies the source fields that produced each flag; it does not upgrade the certainty of the pairwise claim.

High-Priority Caution

147 flagged pairings

Bleeding / anticoagulant risk

Representative pairings are shown below. Large mechanism groups are intentionally summarized to keep profiles focused and crawl-efficient.

Bleeding / anticoagulant riskCertainty: Theoretical

Data provenance recorded for 147 of 147 pairings in this mechanism group.

+135 more pairings share this mechanism. Use the Safety Checker to review a specific combination.

Moderate Caution

81 flagged pairings

Blood-pressure effects

Representative pairings are shown below. Large mechanism groups are intentionally summarized to keep profiles focused and crawl-efficient.

Blood-pressure effectsCertainty: Theoretical

Data provenance recorded for 81 of 81 pairings in this mechanism group.

+69 more pairings share this mechanism. Use the Safety Checker to review a specific combination.

Evidence Summary

Profile-wide ·C Limited

Evidence lens

Read as directional context, not settled clinical proof.

LimitedLimited evidence

Human clinical evidence: Not the primary signal

Mechanistic / preclinical: Mechanism mapped — Inflammatory Signaling Modulation · Oxidative Stress Modulation · Mitochondrial Support

Research maturity: Theoretical / mechanistic research — Mechanistic or unresolved evidence is kept separate from established human outcomes.

Safety boundary: Safety note available — Mostly food associated; concentrated extracts may cause GI effects or interact with anticoagulants/antidiabetics depending matrix.

This profile cites 1 human study.

Evidence Strength

Confidence estimate based on the design quality and consistency of published clinical trials.

Limited evidence

Ferulic Acid has a limited evidence rating.

AdaptogenStress & MoodLongevity
Citation density
0.2
Sources
1
Effects
5
Research recency
Mixed recency
How evidence grades work

Each grade reflects the strength and consistency of published human evidence — not marketing claims. Grades are based on study count, design quality, effect size, consistency, and recency.

Strong
Multiple RCTs, consistent direction, adequate effect size
Moderate
Some RCTs or consistent observational data in humans
Preliminary / Mixed
Animal or in-vitro only, or conflicting human data
Traditional / Theoretical
Traditional use only; no controlled human trials
Clinical Study Summaries (1)0 human evidence sources · 0 human trials · Participant totals not consistently reported · Consistency not yet classifiable

What the evidence actually shows

This table contains 1 structured source, including 0 human evidence sources; 0 are human trials.

StudyDesignNDoseDurationPopulationOutcomeResult & magnitudeSource

Bioavailability of ferulic acid

Bourne LC and Rice-Evans C · Biochem Biophys Res Commun · 1998

Background
Other / unclear

The study design is not yet classified clearly enough to infer its place in the evidence hierarchy.

——————PubMed →

How Ferulic Acid Works

Simplified mechanism pathway based on preclinical and pharmacological evidence. Does not confirm clinical efficacy.

Mechanism Pathway — How Ferulic Acid Works

How Ferulic Acid WorksFerulic Acid acts on biological target pathways via anti inflammatory, leading to nrf2.Ferulic AcidBiological TargetBiological pathwayAnti InflammatoryNrf2Observable outcomeAntioxidantParallel pathway
CompoundTarget / ReceptorMechanismEffect / Outcome

Dosing

Common form
standardized extract capsule
No standardized dose
Our source data records the usual product form for this ingredient but no studied dose. Preparations differ widely, so follow the standardization on the product you actually have and speak to a clinician before starting.
Mechanisms & biological pathways

Preclinical mechanism details from scientific profiles; these represent plausible pathways but do not guarantee clinical efficacy in humans.

  • Inflammatory Signaling Modulation
  • Oxidative Stress Modulation
  • Mitochondrial Support
  • Metabolic Regulation
  • NF KB Modulation
  • Nrf2 Activation

Botanical Context

Source botanicals and comparison guides related to Ferulic Acid.

Found in

Compare active botanicals

Compare & Sourcing

Compare side-by-side tradeoffs or verify active marker guidelines.

Safety first · Harm reduction

This information is educational and not medical advice. Start low, avoid risky combinations, and consult a licensed clinician before making health decisions—especially if you use medications, have diagnosed conditions, or are pregnant/breastfeeding.

Learn how we evaluate confidence, safety, and intensity on the methodology page.

By Willie B. Randolph III

Founder & Head Researcher · Oak Ridge, TN · Last reviewed August 2026

Editorial Review

Checked against primary sources, cited evidence, and contraindication language before publication. Evidence claims, safety language, and affiliate modules are reviewed independently. Not personal medical advice.

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