Compound Profile
Crocetin
Apocarotenoid aglycone from saffron derived from crocin hydrolysis.
Last reviewed: •1 human studies cited
C PreliminaryMonograph visual
Crocetin
Generated profile category visual
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Quick Stats
Evidence level
Limited evidence
Typical onset
Varies by prep
Safety rating
Use extra caution: Use caution
Best for
Nrf2, NF κB, Oxidative Stress Signaling
Avoid / review if
Caution With Bleeding Disorders Or Anticoagulant Or Blood Thinning Medication Use, Caution With Blood Pressure Medications Due To Saffron's Antihypertensive Activity, Caution With Unbalanced Bipolar Disorder Due To Serotonergic Activity
Found In
Botanicals that contain Crocetin, with full herb profiles.
Safety & Cautions
Review before use if any apply: Caution With Bleeding Disorders Or Anticoagulant Or Blood Thinning Medication Use, Caution With Blood Pressure Medications Due To Saffron's Antihypertensive Activity, Caution With Unbalanced Bipolar Disorder Due To Serotonergic Activity.
Evidence-based safety
Caution when combined
These pairings share a flagged risk mechanism. They are additive-effect cautions derived from contraindication data, not confirmed clinical interactions. Consult a clinician before combining.
High-Priority Caution
173 flagged pairingsSerotonergic activity · Bleeding / anticoagulant risk
High-Priority Caution
173 flagged pairingsSerotonergic activity · Bleeding / anticoagulant risk
Browse the grouped cautions below. The list scrolls inside this card when long.
Serotonergic activity
- 5-HTP
- Caffeine
- crocin
- Crocus Sativus
- Damiana
- DMT
- Ginkgo
- Panax Red Ginseng
- Panax White Ginseng
- Harmaline
- Harmine
- Kanna
- Mucuna
- Mucuna pruriens
- Passionflower
- Passionflower
- Passionflower Extract (Standardized)
- Phenylalanine
- Rhodiola
- Rhodiola Extract SHR-5
- Saffron
- Saffron Extract
- St. John's Wort (Hypericum perforatum)
- Tryptophan
- Yohimbe
- Yohimbine
Bleeding / anticoagulant risk
- aescin
- Aged Garlic Extract
- ajoene
- Ajwain
- Allicin
- Garlic
- American Ginseng Extract
- Andrographis
- Angelica Archangelica
- Angelica Dahurica
- Angelica Pubescens
- Angelica Root
- Angelica Sinensis
- Arjuna
- Artemisia Capillaris
- Artichoke
- Ashitaba
- Ashitaba Extract
- Astaxanthin
- Berberis
- Black Seed
- Black Seed Oil
- Blueberry
- Boldo
- Boswellia
- Capsicum
- Caraway
- Carnitine L Tartrate
- Cayenne
- Chamomile
- Chinese Skullcap
- Chuanxiong
- Cissus
- Citicoline
- Clove
- Cnidium Monnieri
- Coleus Forskohlii
- Commiphora Mukul
- Coenzyme Q10
- Cordyceps
- Cranberry (Vaccinium macrocarpon)
- crocin
- cryptotanshinone
- Curcuma Wenyujin
- Curcumin
- Damiana
- Danshen
- Devils Claw Extract
- Dong Quai
- EGCG
- Epimedium
- Epimedium Brevicornum
- Evening Primrose (Oenothera biennis)
- Fenugreek
- Fenugreek Extract
- ferulic acid
- Feverfew
- Fisetin
- forskolin
- Fraxinus Rhynchophylla
- Fucoxanthin
- Galangal
- Reishi
- Garcinia Mangostana
- Garlic (Allium sativum)
- Garlic Aged Extract
- Garlic Extract
- Ginger (Zingiber officinale)
- Ginkgo
- Ginkgo Biloba Extract
- Ginkgo Extract EGb 761
- Panax Red Ginseng
- Panax White Ginseng
- ginsenoside rg3
- Glucosamine
- Goldenseal
- Lion's Mane
- Holy Basil / Tulsi (Ocimum tenuiflorum)
- Horse Chestnut
- hydroxytyrosol
- Japanese Knotweed
- Kudzu
- L-Carnitine
- Ligusticum Chuanxiong
- Magnolia
- Mangosteen
- Maral Root
- Chamomile
- Melatonin
- MSM
- Myrtle
- Nettle Root
- Nigella Sativa
- Noni
- Notoginseng
- Ocimum Basilicum
- Olive Leaf Extract
- Oregano
- Paeonia Lactiflora
- Asian Ginseng
- Panax Ginseng Extract
- Papaya Leaf
- Pastinaca Sativa
- Pau D'arco
- Perilla
- Phosphatidylserine
- Piper Longum
- Bifidobacterium Probiotic
- Lactobacillus Probiotic
- Probiotics - Bifidobacterium spp.
- Probiotics - Lactobacillus spp.
- Psoralea Corylifolia
- Pycnogenol
- Quercetin
- Quercetin Phytosome
- Red Clover
- Reishi (Ganoderma lucidum)
- Resveratrol
- Rhodiola Extract SHR-5
- Rose Hips
- Rosemary
- Saffron
- Saffron Extract
- Salvia miltiorrhiza
- Saw Palmetto (Serenoa repens)
- Saw Palmetto Extract
- Schisandra Berry
- Schisandra Chinensis
- Scutellaria Baicalensis
- Selaginella Tamariscina
- Soybean
- Syzygium Aromaticum
- Terminalia arjuna
- Thunder God Vine
- Thyme
- Tongkat Ali
- Trans-Resveratrol
- Fenugreek
- Tripterygium Wilfordii
- Turmeric (Curcuma longa)
- Turmeric Curcumin + Piperine
- Valerian
- Vitamin D3 + K2
- Grape
- White Peony
- Willow Bark Extract
- Yarrow
Moderate Caution
81 flagged pairingsBlood-pressure effects
Moderate Caution
81 flagged pairingsBlood-pressure effects
Browse the grouped cautions below. The list scrolls inside this card when long.
Blood-pressure effects
- Agmatine sulfate
- ajoene
- Allicin
- American Ginseng Extract
- Andrographis
- Angelica Dahurica
- Astaxanthin
- Astragalus Membranaceus
- Beetroot extract
- Berberis
- Bicarbonate
- Black Seed
- Black Seed Oil
- Brassica Oleracea
- Buckwheat
- Caffeine
- Capsicum
- Caraway
- Chuanxiong
- Citicoline
- Citrus Bergamia
- Cnidium Monnieri
- Coenzyme Q10
- Coffee Cherry
- Coleus Forskohlii
- Hawthorn
- crocin
- Crocus Sativus
- Cymbopogon Citratus
- Dandelion
- Danshen
- Dendrobium
- Devils Claw Extract
- Electrolyte Mix
- Sodium electrolytes
- Eleuthero
- EGCG
- Epimedium
- Epimedium Brevicornum
- Eucommia
- ferulic acid
- forskolin
- Garlic Extract
- Gastrodia
- Panax Red Ginseng
- Panax White Ginseng
- Glycyrrhiza Glabra
- Guarana
- Guayusa
- Hibiscus
- Huperzia Serrata
- L-Tyrosine
- Lemongrass
- Licorice
- Ligusticum Chuanxiong
- Lobelia Inflata
- Luo Han Guo
- Moringa
- Mucuna
- Myristica Fragrans
- Nettle Root
- Nicotiana Glauca
- Nicotiana Tabacum
- Nigella Sativa
- Nicotinamide Mononucleotide
- Notoginseng
- Olive Leaf
- Olive Leaf Extract
- Panax Ginseng Extract
- Parsley
- Poria
- PT-141 (Bremelanotide)
- Punarnava
- Quercetin Phytosome
- Saffron Extract
- Sodium
- Soursop
- Ashwagandha
- Yerba Mate
- Yohimbe
- Yohimbine
Evidence Summary
C PreliminaryEvidence lens
Early signal that needs stronger human replication before practical claims.
PreliminaryLimited evidence
Human clinical evidence: Present in source signals
Mechanistic / preclinical: Mechanism mapped — Inflammatory Signaling Modulation · Oxidative Stress Modulation · Mitochondrial Support
Research maturity: Preliminary or mixed — main contexts: Nrf2 · NF κB · Oxidative Stress Signaling
Safety boundary: Safety note available — Review before use if any apply: Caution With Bleeding Disorders Or Anticoagulant Or Blood Thinning Medication Use, Caution With Blood Pressure Medications Due To Saffron's Antihypertensive Activity, Caution With Unbalanc
This profile cites 1 human study.
Evidence Strength
Confidence estimate based on the design quality and consistency of published clinical trials.
Crocetin has a limited evidence evidence rating.
AdaptogenStress & MoodLongevity
Citation density
0.2
Sources
1
Effects
5
Research recency
Mixed recency
How evidence grades work
Each grade reflects the strength and consistency of published human evidence — not marketing claims. Grades are based on study count, design quality, effect size, consistency, and recency.
A
Strong
Multiple RCTs, consistent direction, adequate effect size
B
Moderate
Some RCTs or consistent observational data in humans
C
Preliminary / Mixed
Animal or in-vitro only, or conflicting human data
D
Traditional / Theoretical
Traditional use only; no controlled human trials
Clinical Study Summaries (1)Cited studies informing this profile. RCTs and reviews shown first.
| Study | Type | Sample | Source |
|---|---|---|---|
Crocetin: A Systematic Review. (2021) | Systematic review | — | PubMed → |
How Crocetin Works
Simplified mechanism pathway based on preclinical and pharmacological evidence. Does not confirm clinical efficacy.
Mechanism Pathway — How Crocetin Works
CompoundTarget / ReceptorMechanismEffect / Outcome
Mechanisms & Biological Pathways▼
Preclinical mechanism details from scientific profiles; these represent plausible pathways but do not guarantee clinical efficacy in humans.
Inflammatory Signaling ModulationOxidative Stress ModulationMitochondrial SupportMetabolic RegulationVascular Function SupportStress Response Modulation
Condition guides
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Related research paths
Compare & Sourcing
Compare side-by-side tradeoffs or verify active marker guidelines.
Review available sources for Crocetin
Independent database mapping — evaluated separately from safety and efficacy scores.
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Related alternatives
Herbs for similar conditions
Tradeoffs
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Safety first · Harm reduction
This information is educational and not medical advice. Start low, avoid risky combinations, and consult a licensed clinician before making health decisions—especially if you use medications, have diagnosed conditions, or are pregnant/breastfeeding.
Learn how we evaluate confidence, safety, and intensity on the methodology page.
Editorial Review
Checked against primary sources, cited evidence, and contraindication language before publication. Evidence claims, safety language, and affiliate modules are reviewed independently. Not personal medical advice.
Compound profile context
How to interpret Crocetin
Crocetin dosage by use case, onset and duration, safety limits, and interactions for nrf2, graded against research. Limited Human Evidence research evidence. Use this compound profile to understand mechanism, evidence quality, and practical safety context before comparing products or building a stack. A biochemical pathway connection can be useful for discovery, but it is not the same as proven benefit in humans.
When reviewing Crocetin, separate the active molecule from the product category around it. Dose form, absorption, extract standardization, medication interactions, and individual sensitivity can change the real-world risk-benefit picture.
For supplement planning, avoid combining multiple compounds with overlapping sedating, stimulating, serotonergic, blood-pressure, anticoagulant, or liver-metabolism effects unless a qualified clinician has reviewed the context.