What is Desmethoxyyangonin used for?

Minor kavalactone from kava associated with monoamine and GABAergic signaling effects.

Desmethoxyyangonin: Effects, Dose & Safety

At a glance

From this profile's structured data

Evidence: Grade C
Safety: Kava/kavalactones are linked with sedation and liver injury concerns; avoid alcohol, sedatives, liver disease, and pregnancy.
Profile context: GABAergic signaling, voltage-gated ion channels, monoamine signaling

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Quick stats

Evidence level: Limited evidence
Typical onset: Varies by prep
Safety rating: Use extra caution: Use caution
Best for: GABAergic Signaling, Voltage Gated Ion Channels, Monoamine Signaling
Avoid / review if: Pregnancy, Liver

Botanical Context

Source botanicals and comparison guides related to Desmethoxyyangonin.

Found in

Kava, a natural source of Desmethoxyyangonin

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Open the full activity atlasCompare effects, evidence, and safety

Safety

Safety & Cautions

Kava/kavalactones are linked with sedation and liver injury concerns; avoid alcohol, sedatives, liver disease, and pregnancy.

High caution

Caution level: High. Multiple caution categories apply, or the record uses avoid/contraindication language.

Liver-SensitiveLiver-related caution language appears in the profile.

Evidence Summary

Profile-wide ·C Limited

Evidence lens

Read as directional context, not settled clinical proof.

LimitedLimited evidence

Human clinical evidence: Not the primary signal

Mechanistic / preclinical: Mechanism mapped — Neurotransmitter Modulation · Stress Response Modulation · Neuroprotective Activity

Research maturity: Theoretical / mechanistic research — Mechanistic or unresolved evidence is kept separate from established human outcomes.

Safety boundary: Safety note available — Kava/kavalactones are linked with sedation and liver injury concerns; avoid alcohol, sedatives, liver disease, and pregnancy.

Evidence Strength

Confidence estimate based on the design quality and consistency of published clinical trials.

Limited evidence

Desmethoxyyangonin has a limited evidence rating.

AdaptogenStress & Mood

Effects

How evidence grades work

Each grade reflects the strength and consistency of published human evidence — not marketing claims. Grades are based on study count, design quality, effect size, consistency, and recency.

Strong: Multiple RCTs, consistent direction, adequate effect size
Moderate: Some RCTs or consistent observational data in humans
Preliminary / Mixed: Animal or in-vitro only, or conflicting human data
Traditional / Theoretical: Traditional use only; no controlled human trials

How Desmethoxyyangonin Works

Simplified mechanism pathway based on preclinical and pharmacological evidence. Does not confirm clinical efficacy.

Mechanism Pathway — How Desmethoxyyangonin Works

CompoundTarget / ReceptorMechanismEffect / Outcome

Dosing

Common form: capsule or standardized extract
No standardized dose: Our source data records the usual product form for this ingredient but no studied dose. Preparations differ widely, so follow the standardization on the product you actually have and speak to a clinician before starting.

Mechanisms & biological pathways

Preclinical mechanism details from scientific profiles; these represent plausible pathways but do not guarantee clinical efficacy in humans.

Neurotransmitter Modulation
Stress Response Modulation
Neuroprotective Activity

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Related research paths

Related Compounds

Compounds connected by the same goals, effects, or research topics.

Related Herbs

Botanicals connected by the same goals, effects, or research topics.

Related Guides

Deeper context, comparisons, and practical research paths.

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Sourcing options disabled for safety

Direct product recommendations and affiliate links are suppressed for this compound due to its high caution or needs-review safety classification.

Evaluate the safety checks, contraindications, and potential medication interactions above under clinician supervision before use.

Safety first · Harm reduction

This information is educational and not medical advice. Start low, avoid risky combinations, and consult a licensed clinician before making health decisions—especially if you use medications, have diagnosed conditions, or are pregnant/breastfeeding.

Learn how we evaluate confidence, safety, and intensity on the methodology page.

Editorial Review

Checked against primary sources, cited evidence, and contraindication language before publication. Evidence claims, safety language, and affiliate modules are reviewed independently. Not personal medical advice.

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