Compound Profile
Garcinia Cambogia Extract
Garcinia Cambogia Extract carries a Grade C rating — limited evidence.
Last reviewed: •1 source citedReport a correctionProfile-wide ·C Limited
Use extra caution — GI upset; rare hepatotoxicity reports; caution in liver disease. Details
- Evidence
- Limited evidence
- Typical onset
- Varies by prep
- Safety rating
- Use extra caution: Use caution
- Best for
- ATP Citrate Lyase
- Avoid / review if
- Avoid In Pre Existing Liver Disease Or With Other Hepatotoxic Medications
Safety
Safety & Cautions
GI upset; rare hepatotoxicity reports; caution in liver disease.
High caution
Caution level: High. Multiple caution categories apply, or the record uses avoid/contraindication language.
- Interaction-AwareMedication or interaction context is explicitly noted.
- Liver-SensitiveLiver-related caution language appears in the profile.
- Pregnancy/Breastfeeding CautionPregnancy or breastfeeding caution language is present.
Evidence Summary
Profile-wide ·C LimitedEvidence lens
Read as directional context, not settled clinical proof.
LimitedLimited evidence
Human clinical evidence: Present in source signals
Mechanistic / preclinical: Mechanism mapped — Mitochondrial Support · Metabolic Regulation · Metabolic
Research maturity: Emerging research — main contexts: ATP Citrate Lyase
Safety boundary: Safety note available — GI upset; rare hepatotoxicity reports; caution in liver disease.
This profile cites 1 human study.
Evidence Strength
Confidence estimate based on the design quality and consistency of published clinical trials.
Garcinia Cambogia Extract has a limited evidence rating.
General wellnessGeneral wellness
Citation density
1.0
Sources
1
Effects
1
Research recency
Mixed recency
Evidence Grade
Grade C: Limited Evidence
Evaluation of methodological rigor, population reach, and evidence alignment.
- Design Match
- Randomized controlled trial
- Risk of Bias
- Low
- Consistency
- Not assessed
Strongest recorded design is a randomized controlled trial, drawn from 2 recorded studies, 2 in people.
How evidence grades work
Each grade reflects the strength and consistency of published human evidence — not marketing claims. Grades are based on study count, design quality, effect size, consistency, and recency.
- Strong
- Multiple RCTs, consistent direction, adequate effect size
- Moderate
- Some RCTs or consistent observational data in humans
- Preliminary / Mixed
- Animal or in-vitro only, or conflicting human data
- Traditional / Theoretical
- Traditional use only; no controlled human trials
Clinical Study Summaries (1)1 human evidence source · 1 human trial · ~135 participants across 1 human evidence source with reported N · Consistency not yet classifiable
What the evidence actually shows
This table contains 1 structured source, including 1 human evidence source; 1 is a human trial. Across 1 human evidence source with a reported sample size, the approximate participant total is 135; overlapping publications may include some of the same people.
| Study | Design | N | Dose | Duration | Population | Outcome | Result & magnitude | Source |
|---|---|---|---|---|---|---|---|---|
PubMed · JAMA · 1998 Background | Randomized controlled trial Randomly assigns participants to interventions or controls, reducing many sources of bias when the trial is conducted well. | n=135 | — | — | — | — | — | PubMed → |
How Garcinia Cambogia Extract Works
Simplified mechanism pathway based on preclinical and pharmacological evidence. Does not confirm clinical efficacy.
Mechanism Pathway — How Garcinia Cambogia Extract Works
CompoundTarget / ReceptorMechanismEffect / Outcome
Dosing
- Common form
- standardized extract
- No standardized dose
- Our source data records the usual product form for this ingredient but no studied dose. Preparations differ widely, so follow the standardization on the product you actually have and speak to a clinician before starting.
Mechanisms & biological pathways
Preclinical mechanism details from scientific profiles; these represent plausible pathways but do not guarantee clinical efficacy in humans.
- Mitochondrial Support
- Metabolic Regulation
- Metabolic
Compare & Sourcing
Compare side-by-side tradeoffs or verify active marker guidelines.
Review available sources for Garcinia Cambogia Extract
Independent database mapping — evaluated separately from safety and efficacy scores.
Affiliate disclosure: Shopping links may earn this site a commission at no cost to you. Links are chosen on quality and availability, never commission tiers; safety warnings and evidence ratings stay independent.
Safety first · Harm reduction
This information is educational and not medical advice. Start low, avoid risky combinations, and consult a licensed clinician before making health decisions—especially if you use medications, have diagnosed conditions, or are pregnant/breastfeeding.
Learn how we evaluate confidence, safety, and intensity on the methodology page.
Founder & Head Researcher · Oak Ridge, TN · Last reviewed August 2026
Editorial Review
Checked against primary sources, cited evidence, and contraindication language before publication. Evidence claims, safety language, and affiliate modules are reviewed independently. Not personal medical advice.
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