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Compound Profile
Iberogast
Iberogast is best framed as a conservative research profile with mechanistic evidence and a focus on Digestive Health.
Use extra caution — Rare liver injury has been reported with some preparations; caution liver disease and hepatotoxic drugs. Details
Last reviewed: •1 source citedReport a correctionProfile-wide ·D Preliminary
At a glance
From this profile's structured data- Evidence
- Grade D
- Safety
- Rare liver injury has been reported with some preparations; caution liver disease and hepatotoxic drugs.
- Profile context
- Digestive Health, Exercise Performance, Cognition
Quick stats
- Evidence level
- Preliminary evidence
- Typical onset
- Varies by prep
- Safety rating
- Use extra caution: Use caution
- Best for
- Digestive Health, Exercise Performance, Cognition
- Avoid / review if
- Chamomile Or Other Asteraceae Family Plant Allergy (Possible Cross Reactivity)
Safety
Safety & Cautions
Rare liver injury has been reported with some preparations; caution liver disease and hepatotoxic drugs.
High caution
Caution level: High. Multiple caution categories apply, or the record uses avoid/contraindication language.
- Interaction-AwareMedication or interaction context is explicitly noted.
- Liver-SensitiveLiver-related caution language appears in the profile.
- Pregnancy/Breastfeeding CautionPregnancy or breastfeeding caution language is present.
Evidence Summary
Profile-wide ·D PreliminaryEvidence lens
Early signal that needs stronger human replication before practical claims.
PreliminaryPreliminary evidence
Human clinical evidence: Present in source signals
Mechanistic / preclinical: Mechanism mapped — Multi Herb Preparation May Modulate Gastric Motility · Smooth Muscle Tone · And Visceral Sensitivity.
Research maturity: Preliminary research — Early findings are not treated as established consumer benefit.
Safety boundary: Safety note available — Rare liver injury has been reported with some preparations; caution liver disease and hepatotoxic drugs.
This profile cites 1 human study.
Evidence Strength
Confidence estimate based on the design quality and consistency of published clinical trials.
Iberogast has a preliminary evidence rating.
NootropicFocusRecovery
Citation density
0.3
Sources
1
Effects
3
Research recency
Mixed recency
Evidence Grade
Grade D: Preliminary / Theoretical Evidence
Evaluation of methodological rigor, population reach, and evidence alignment.
- Design Match
- Systematic review
- Risk of Bias
- Low
- Consistency
- Not assessed
Strongest recorded design is a systematic review, drawn from 2 recorded studies, 2 in people.
How evidence grades work
Each grade reflects the strength and consistency of published human evidence — not marketing claims. Grades are based on study count, design quality, effect size, consistency, and recency.
- Strong
- Multiple RCTs, consistent direction, adequate effect size
- Moderate
- Some RCTs or consistent observational data in humans
- Preliminary / Mixed
- Animal or in-vitro only, or conflicting human data
- Traditional / Theoretical
- Traditional use only; no controlled human trials
Clinical Study Summaries (1)1 human evidence source · 0 human trials · ~595 participants across 1 human evidence source with reported N · Consistency not yet classifiable
What the evidence actually shows
This table contains 1 structured source, including 1 human evidence source; 0 are human trials. Across 1 human evidence source with a reported sample size, the approximate participant total is 595; overlapping publications may include some of the same people.
| Study | Design | N | Dose | Duration | Population | Outcome | Result & magnitude | Source |
|---|---|---|---|---|---|---|---|---|
Iberis amara L. and Iberogast--results of a systematic review concerning functional dyspepsia PubMed · J Herb Pharmacother · 2004 Background | Systematic review Uses a predefined method to find and evaluate relevant studies, but may or may not pool their results statistically. | n=595 | — | — | — | — | — | PubMed → |
How Iberogast Works
Simplified mechanism pathway based on preclinical and pharmacological evidence. Does not confirm clinical efficacy.
Mechanism Pathway — How Iberogast Works
CompoundTarget / ReceptorMechanismEffect / Outcome
Dosing
- No standardized dose
- No standardized dose is established for this ingredient in our source data. Preparations differ widely, so follow the standardization on the product you actually have and speak to a clinician before starting.
Mechanisms & biological pathways
Preclinical mechanism details from scientific profiles; these represent plausible pathways but do not guarantee clinical efficacy in humans.
- Multi Herb Preparation May Modulate Gastric Motility
- Smooth Muscle Tone
- And Visceral Sensitivity.
Guides that use Iberogast
Condition guides
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Compare & Sourcing
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Safety first · Harm reduction
This information is educational and not medical advice. Start low, avoid risky combinations, and consult a licensed clinician before making health decisions—especially if you use medications, have diagnosed conditions, or are pregnant/breastfeeding.
Learn how we evaluate confidence, safety, and intensity on the methodology page.
Editorial Review
Checked against primary sources, cited evidence, and contraindication language before publication. Evidence claims, safety language, and affiliate modules are reviewed independently. Not personal medical advice.
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