Related Compounds
Compounds connected by the same goals, effects, or research topics.
Compound Profile
Iodine
Prevents iodine deficiency disorders and supports thyroid hormone production.
Review needed — Excess may disrupt thyroid function. Details
Last reviewed: •2 sources citedReport a correctionProfile-wide ·D Preliminary
At a glance
From this profile's structured data- Evidence
- Grade D
- Safety
- Excess may disrupt thyroid function.
- Profile context
- thyroid hormone synthesis
Quick stats
- Evidence level
- Preliminary evidence
- Typical onset
- Varies by prep
- Safety rating
- Review needed: Safety review pending
- Best for
- Thyroid Hormone Synthesis
- Avoid / review if
- Lithium Therapy (Additive Hypothyroidism Risk), Amiodarone (Both Contain Iodine And Combined Exposure Raises Thyroid Dysfunction Risk), Not Appropriate For High Dose Supplementation Without Clinician Supervised Thyroid Monitoring
Safety
Safety & Cautions
Excess may disrupt thyroid function.
Elevated caution
Caution level: Elevated. One caution category applies — read it before use.
- Hormonal Activity ContextHormone-adjacent wording is present and should be interpreted carefully.
Evidence Summary
Profile-wide ·D PreliminaryEvidence lens
Early signal that needs stronger human replication before practical claims.
PreliminaryPreliminary evidence
Human clinical evidence: Present in source signals
Mechanistic / preclinical: Mechanism mapped — Hormonal Signaling Context · Endocrine
Research maturity: Preliminary research — Early findings are not treated as established consumer benefit.
Safety boundary: Safety note available — Excess may disrupt thyroid function.
This profile cites 2 human studies.
Evidence Strength
Confidence estimate based on the design quality and consistency of published clinical trials.
Iodine has a preliminary evidence rating.
General wellnessGeneral wellness
Citation density
2.0
Sources
2
Effects
1
Research recency
Mixed recency
Evidence Grade
Grade D: Preliminary / Theoretical Evidence
Evaluation of methodological rigor, population reach, and evidence alignment.
- Design Match
- Meta analysis
- Risk of Bias
- Low
- Consistency
- Not assessed
Strongest recorded design is a meta analysis, drawn from 3 recorded studies, 2 in people.
How evidence grades work
Each grade reflects the strength and consistency of published human evidence — not marketing claims. Grades are based on study count, design quality, effect size, consistency, and recency.
- Strong
- Multiple RCTs, consistent direction, adequate effect size
- Moderate
- Some RCTs or consistent observational data in humans
- Preliminary / Mixed
- Animal or in-vitro only, or conflicting human data
- Traditional / Theoretical
- Traditional use only; no controlled human trials
Clinical Study Summaries (2)1 human evidence source · 0 human trials · ~12,291 participants across 1 human evidence source with reported N · Consistency not yet classifiable
Filter by study class
Showing 2 of 2 studies.
What the evidence actually shows
This table contains 2 structured sources, including 1 human evidence source; 0 are human trials. Across 1 human evidence source with a reported sample size, the approximate participant total is 12,291; overlapping publications may include some of the same people.
| Study | Design | N | Dose | Duration | Population | Outcome | Result & magnitude | Source |
|---|---|---|---|---|---|---|---|---|
The effects of iodine on intelligence in children: a meta-analysis of studies conducted in China PubMed · Asia Pac J Clin Nutr · 2005 Background | Meta-analysis Statistically combines results from multiple eligible studies; confidence still depends on the quality, consistency, and directness of those studies. | n=12291 | — | — | — | — | — | PubMed → |
Background | Other / unclear The study design is not yet classified clearly enough to infer its place in the evidence hierarchy. | — | — | — | — | — | — | Source → |
How Iodine Works
Simplified mechanism pathway based on preclinical and pharmacological evidence. Does not confirm clinical efficacy.
Mechanism Pathway — How Iodine Works
CompoundTarget / ReceptorMechanismEffect / Outcome
Dosing
- Common form
- capsule or standardized extract
- No standardized dose
- Our source data records the usual product form for this ingredient but no studied dose. Preparations differ widely, so follow the standardization on the product you actually have and speak to a clinician before starting.
Mechanisms & biological pathways
Preclinical mechanism details from scientific profiles; these represent plausible pathways but do not guarantee clinical efficacy in humans.
- Hormonal Signaling Context
- Endocrine
Guides that use Iodine
Condition guides
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Compare & Sourcing
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Safety first · Harm reduction
This information is educational and not medical advice. Start low, avoid risky combinations, and consult a licensed clinician before making health decisions—especially if you use medications, have diagnosed conditions, or are pregnant/breastfeeding.
Learn how we evaluate confidence, safety, and intensity on the methodology page.
Editorial Review
Checked against primary sources, cited evidence, and contraindication language before publication. Evidence claims, safety language, and affiliate modules are reviewed independently. Not personal medical advice.
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