Compound Profile

Madecassic Acid

Pentacyclic triterpenoid from Centella asiatica that promotes collagen synthesis and skin barrier repair.

Last reviewed: Report a correctionProfile-wide ·C Limited

Use extra caution — Mostly preclinical or extract derived; concentrated doses may affect glucose, lipids, liver enzymes, or bleeding risk depending matrix. Details

Evidence
Limited evidence
Typical onset
Varies by prep
Safety rating
Use extra caution: Use caution
Best for
NF κB, AMPK, PPAR
Avoid / review if
Liver
Next steps

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Madecassic Acid monograph visual
Generated profile category visual

Safety

Safety & Cautions

Mostly preclinical or extract derived; concentrated doses may affect glucose, lipids, liver enzymes, or bleeding risk depending matrix.

High caution

Caution level: High. Multiple caution categories apply, or the record uses avoid/contraindication language.

  • Liver-SensitiveLiver-related caution language appears in the profile.
  • Anticoagulant CautionBleeding or anticoagulant-adjacent caution language is present.

Evidence Summary

Profile-wide ·C Limited

Evidence lens

Read as directional context, not settled clinical proof.

LimitedLimited evidence

Human clinical evidence: Not the primary signal

Mechanistic / preclinical: Mechanism mapped — Immune Signaling Modulation · Nrf2/ARE Activation · Anti Inflammatory Signaling

Research maturity: Theoretical / mechanistic research — Mechanistic or unresolved evidence is kept separate from established human outcomes.

Safety boundary: Safety note available — Mostly preclinical or extract derived; concentrated doses may affect glucose, lipids, liver enzymes, or bleeding risk depending matrix.

Evidence Strength

Confidence estimate based on the design quality and consistency of published clinical trials.

Limited evidence

Madecassic Acid has a limited evidence rating.

General wellnessGeneral wellness
Effects
5
How evidence grades work

Each grade reflects the strength and consistency of published human evidence — not marketing claims. Grades are based on study count, design quality, effect size, consistency, and recency.

Strong
Multiple RCTs, consistent direction, adequate effect size
Moderate
Some RCTs or consistent observational data in humans
Preliminary / Mixed
Animal or in-vitro only, or conflicting human data
Traditional / Theoretical
Traditional use only; no controlled human trials

How Madecassic Acid Works

Simplified mechanism pathway based on preclinical and pharmacological evidence. Does not confirm clinical efficacy.

Mechanism Pathway — How Madecassic Acid Works

How Madecassic Acid WorksMadecassic Acid acts on biological target pathways via anti inflammatory, leading to nf κb.Madecassic AcidBiological TargetBiological pathwayAnti InflammatoryNf κBObservable outcomeMetabolicRegulation
CompoundTarget / ReceptorMechanismEffect / Outcome

Dosing

No standardized dose
standardized extract or essential oil free preparation when oral use is intended
Mechanisms & biological pathways

Preclinical mechanism details from scientific profiles; these represent plausible pathways but do not guarantee clinical efficacy in humans.

  • Immune Signaling Modulation
  • Nrf2/ARE Activation
  • Anti Inflammatory Signaling
  • Metabolic Regulation
  • AMPK Signaling
  • NF KB Modulation

Botanical Context

Source botanicals and comparison guides related to Madecassic Acid.

Found in

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Compare & Sourcing

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Safety first · Harm reduction

This information is educational and not medical advice. Start low, avoid risky combinations, and consult a licensed clinician before making health decisions—especially if you use medications, have diagnosed conditions, or are pregnant/breastfeeding.

Learn how we evaluate confidence, safety, and intensity on the methodology page.

By Willie B. Randolph III

Founder & Head Researcher · Oak Ridge, TN · Last reviewed August 2026

Editorial Review

Checked against primary sources, cited evidence, and contraindication language before publication. Evidence claims, safety language, and affiliate modules are reviewed independently. Not personal medical advice.

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