Related Compounds
Compounds connected by the same goals, effects, or research topics.
Compound Profile
Mangiferin Aglycone
Xanthone aglycone metabolite of mangiferin produced by gut microbiota after oral ingestion.
Use extra caution — Mostly preclinical/extract derived; concentrated Garcinia/mangosteen extracts may affect bleeding or liver risk depending product. Details
Last reviewed: Report a correctionProfile-wide ·C Limited
At a glance
From this profile's structured data- Evidence
- Grade C
- Safety
- Mostly preclinical/extract-derived; concentrated Garcinia/mangosteen extracts may affect bleeding or liver risk depending product.
- Profile context
- NF-κB, antioxidant response, apoptosis signaling
Next stepsWhere to go next — guides & comparisons
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Quick stats
- Evidence level
- Limited evidence
- Typical onset
- Varies by prep
- Safety rating
- Use extra caution: Use caution
- Best for
- NF κB, Antioxidant Response, Apoptosis Signaling
- Avoid / review if
- Liver
Botanical Context
Source botanicals and comparison guides related to Mangiferin Aglycone.
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Safety
Safety & Cautions
Mostly preclinical/extract derived; concentrated Garcinia/mangosteen extracts may affect bleeding or liver risk depending product.
High caution
Caution level: High. Multiple caution categories apply, or the record uses avoid/contraindication language.
- Liver-SensitiveLiver-related caution language appears in the profile.
- Anticoagulant CautionBleeding or anticoagulant-adjacent caution language is present.
Evidence Summary
Profile-wide ·C LimitedEvidence lens
Read as directional context, not settled clinical proof.
LimitedLimited evidence
Human clinical evidence: Not the primary signal
Mechanistic / preclinical: Mechanism mapped — Immune Signaling Modulation · AMPK Pathway Activation · Metabolic Regulation
Research maturity: Theoretical / mechanistic research — Mechanistic or unresolved evidence is kept separate from established human outcomes.
Safety boundary: Safety note available — Mostly preclinical/extract derived; concentrated Garcinia/mangosteen extracts may affect bleeding or liver risk depending product.
Evidence Strength
Confidence estimate based on the design quality and consistency of published clinical trials.
Mangiferin Aglycone has a limited evidence rating.
AdaptogenStress & MoodLongevity
Effects
4
How evidence grades work
Each grade reflects the strength and consistency of published human evidence — not marketing claims. Grades are based on study count, design quality, effect size, consistency, and recency.
- Strong
- Multiple RCTs, consistent direction, adequate effect size
- Moderate
- Some RCTs or consistent observational data in humans
- Preliminary / Mixed
- Animal or in-vitro only, or conflicting human data
- Traditional / Theoretical
- Traditional use only; no controlled human trials
How Mangiferin Aglycone Works
Simplified mechanism pathway based on preclinical and pharmacological evidence. Does not confirm clinical efficacy.
Mechanism Pathway — How Mangiferin Aglycone Works
CompoundTarget / ReceptorMechanismEffect / Outcome
Dosing
- Common form
- standardized extract capsule
- No standardized dose
- Our source data records the usual product form for this ingredient but no studied dose. Preparations differ widely, so follow the standardization on the product you actually have and speak to a clinician before starting.
Mechanisms & biological pathways
Preclinical mechanism details from scientific profiles; these represent plausible pathways but do not guarantee clinical efficacy in humans.
- Immune Signaling Modulation
- AMPK Pathway Activation
- Metabolic Regulation
- Nrf2/ARE Pathway Activation
- AMPK Signaling
- Mitochondrial Support
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Compare & Sourcing
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Safety first · Harm reduction
This information is educational and not medical advice. Start low, avoid risky combinations, and consult a licensed clinician before making health decisions—especially if you use medications, have diagnosed conditions, or are pregnant/breastfeeding.
Learn how we evaluate confidence, safety, and intensity on the methodology page.
Editorial Review
Checked against primary sources, cited evidence, and contraindication language before publication. Evidence claims, safety language, and affiliate modules are reviewed independently. Not personal medical advice.
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