Compound Profile
Naringenin
Citrus flavanone reported to influence AMPK and PI3K/Akt signaling.
Last reviewed:
B ModerateMonograph visual
Naringenin
Generated profile category visual
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Quick Stats
Evidence level
Moderate evidence
Typical onset
Varies by prep
Safety rating
Use extra caution: Interaction risk
Best for
AMPK, PPAR Signaling, NF κB
Found In
Botanicals that contain Naringenin, with full herb profiles.
Safety & Cautions
well tolerated; possible interaction with drug metabolism enzymes; well tolerated; may interact with CYP450 enzymes | Citrus derived compounds are generally food associated, but grapefruit/citrus extracts can interact with CYP3A4/OATP/P gp substrates.
Evidence Summary
B ModerateEvidence lens
Useful signal, but study design, dose, and population still matter.
ModerateModerate evidence
Human clinical evidence: Present in source signals
Mechanistic / preclinical: Mechanism mapped — AMPK Pathway Activation · PI3K/Akt Pathway Modulation · Anti Inflammatory Signaling
Research maturity: More interpretable — main contexts: AMPK · PPAR Signaling · NF κB
Safety boundary: Safety note available — well tolerated; possible interaction with drug metabolism enzymes; well tolerated; may interact with CYP450 enzymes | Citrus derived compounds are generally food associated, but grapefruit/citrus extracts can interact wi
Evidence Strength
Confidence estimate based on the design quality and consistency of published clinical trials.
Naringenin has a moderate evidence evidence rating.
AdaptogenStress & MoodLongevity
Effects
6
How evidence grades work
Each grade reflects the strength and consistency of published human evidence — not marketing claims. Grades are based on study count, design quality, effect size, consistency, and recency.
A
Strong
Multiple RCTs, consistent direction, adequate effect size
B
Moderate
Some RCTs or consistent observational data in humans
C
Preliminary / Mixed
Animal or in-vitro only, or conflicting human data
D
Traditional / Theoretical
Traditional use only; no controlled human trials
How Naringenin Works
Simplified mechanism pathway based on preclinical and pharmacological evidence. Does not confirm clinical efficacy.
Mechanism Pathway — How Naringenin Works
CompoundTarget / ReceptorMechanismEffect / Outcome
Mechanisms & Biological Pathways▼
Preclinical mechanism details from scientific profiles; these represent plausible pathways but do not guarantee clinical efficacy in humans.
AMPK Pathway ActivationPI3K/Akt Pathway ModulationAnti Inflammatory SignalingMetabolic RegulationAMPK SignalingMitochondrial Support
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Review available sources for Naringenin
Independent database mapping — evaluated separately from safety and efficacy scores.
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Related alternatives
Herbs for similar conditions
Tradeoffs
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Safety first · Harm reduction
This information is educational and not medical advice. Start low, avoid risky combinations, and consult a licensed clinician before making health decisions—especially if you use medications, have diagnosed conditions, or are pregnant/breastfeeding.
Learn how we evaluate confidence, safety, and intensity on the methodology page.
Editorial Review
Checked against primary sources, cited evidence, and contraindication language before publication. Evidence claims, safety language, and affiliate modules are reviewed independently. Not personal medical advice.
Compound profile context
How to interpret Naringenin
Naringenin dosage by use case, onset and duration, safety limits, and interactions for ampk, graded against research. Moderate Human Evidence research evidence. Use this compound profile to understand mechanism, evidence quality, and practical safety context before comparing products or building a stack. A biochemical pathway connection can be useful for discovery, but it is not the same as proven benefit in humans.
When reviewing Naringenin, separate the active molecule from the product category around it. Dose form, absorption, extract standardization, medication interactions, and individual sensitivity can change the real-world risk-benefit picture.
For supplement planning, avoid combining multiple compounds with overlapping sedating, stimulating, serotonergic, blood-pressure, anticoagulant, or liver-metabolism effects unless a qualified clinician has reviewed the context.