Herb Profile

Paeonia Suffruticosa

Botanical profile with evidence, safety, and practical fit.

Last reviewed: •3 human studies cited

C Preliminary

Use extra caution — Immune modulating activity is plausible; use caution with autoimmune disease, transplant medicines, or immunosuppressants. Details

Evidence
Limited Human Evidence
Typical onset
Varies by prep
Safety rating
High caution
Best for
Anti Inflammatory, Cardiovascular, Inflammatory signaling, Hormonal effects
Avoid / review if
Pregnancy/Breastfeeding Without Clinician Supervision, Known Allergy To The Plant/Family, Hormone Sensitive Conditions Without Clinician Review

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Paeonia Suffruticosa

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Safety & Cautions

Immune modulating activity is plausible; use caution with autoimmune disease, transplant medicines, or immunosuppressants.

28%

High caution — review carefully

Detailed safety fields

Pregnancy, breastfeeding, and contraindications

  • - Pregnancy/Breastfeeding Without Clinician Supervision
  • - Known Allergy To The Plant/Family
  • - Hormone Sensitive Conditions Without Clinician Review
  • - Potential Interaction Concern With Hormonal Therapies
  • - Immunosuppressants
  • - Use Clinician Review For High Dose Extracts Or Chronic Use.

Safety classifications

  • - Interaction-Aware: Medication or interaction context is explicitly noted.
  • - Hormonal Activity Context: Hormone-adjacent wording is present and should be interpreted carefully.
  • - Pregnancy/Breastfeeding Caution: Pregnancy or breastfeeding caution language is present.

Full safety note

  • - Immune modulating activity is plausible; use caution with autoimmune disease, transplant medicines, or immunosuppressants.

Safety labels

  • - Interaction-Aware
  • - Hormonal Activity Context
  • - Pregnancy/Breastfeeding Caution

Evidence Summary

Evidence lens

Early signal that needs stronger human replication before practical claims.

PreliminaryLimited Human Evidence

Human clinical evidence: Present in source signals

Mechanistic / preclinical: Mechanism mapped — Inflammatory Signaling Modulation · Vascular Function Support · Hormonal Signaling Context

Research maturity: Preliminary or mixed — Long Term Human Evidence May Be Limited.

Safety boundary: Safety note available — Immune modulating activity is plausible; use caution with autoimmune disease, transplant medicines, or immunosuppressants.

This profile cites 3 human studies.

How evidence grades work

Each grade reflects the strength and consistency of published human evidence — not marketing claims. Grades are based on study count, design quality, effect size, consistency, and recency.

A

Strong

Multiple RCTs, consistent direction, adequate effect size

B

Moderate

Some RCTs or consistent observational data in humans

C

Preliminary / Mixed

Animal or in-vitro only, or conflicting human data

D

Traditional / Theoretical

Traditional use only; no controlled human trials

Clinical Study Summaries (3)Cited studies informing this profile. RCTs and reviews shown first.
StudyTypeSampleSource

Peony

PubMed indexed authors (2006)

——PubMed →

Paeonia suffruticosa Andrews root extract ameliorates photoaging via regulating IRS1/PI3K/FOXO pathway

Liu J et al. (2025)

——PubMed →

Paeonol: pharmacological effects and mechanisms of action

Zhang L et al. (2019)

——PubMed →

Dosing & Timing

Dose guidance

Preparation specific; use standardized product label for Preparation varies by tradition and product form and require source backed dosage review before therapeutic claims.

How Paeonia Suffruticosa Works

Simplified mechanism pathway based on preclinical and pharmacological evidence. Does not confirm clinical efficacy.

Mechanism Pathway — How Paeonia Suffruticosa Works

How Paeonia Suffruticosa WorksPaeonia Suffruticosa acts on pathways via anti inflammatory, leading to anti inflammatory.Paeonia SuffruticosaBiological pathwayAnti InflammatoryAnti InflammatoryObservable outcomeVascular FunctionSupport
CompoundTarget / ReceptorMechanismEffect / Outcome
Mechanisms & Biological Pathways
Preclinical pathways

Proposed mechanisms from in vitro and animal research; these do not confirm clinical outcomes in humans.

Inflammatory Signaling ModulationVascular Function SupportHormonal Signaling ContextNF KB ModulationNrf2 Activation

Active Compounds

Key constituents studied in Paeonia Suffruticosa, with full pharmacology and safety profiles.

Compare & Sourcing

Compare side-by-side tradeoffs or verify active marker guidelines.

Review available sources for Paeonia Suffruticosa

Independent database mapping — evaluated separately from safety and efficacy scores.

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Safety first · Harm reduction

This information is educational and not medical advice. Start low, avoid risky combinations, and consult a licensed clinician before making health decisions—especially if you use medications, have diagnosed conditions, or are pregnant/breastfeeding.

Learn how we evaluate confidence, safety, and intensity on the methodology page.

Editorial Review

Checked against primary sources, cited evidence, and contraindication language before publication. Evidence claims, safety language, and affiliate modules are reviewed independently. Not personal medical advice.

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Botanical profile context

How to interpret Paeonia Suffruticosa

Paeonia Suffruticosa dosage ranges, effects, drug interactions, and harm-reduction safety guide for anti inflammatory. Limited Human Evidence research evidence. Use this herb profile as a starting point for evidence review, not as a recommendation to start a new supplement. Botanical products can vary by plant part, extract ratio, standardization, dose, and contaminant testing, so two labels with the same common name may not behave the same way.

When reviewing Paeonia Suffruticosa, compare the traditional-use context against the human evidence, mechanism notes, and safety cautions. Pay special attention to pregnancy, breastfeeding, liver or kidney disease, blood-pressure effects, sedation, stimulation, anticoagulant use, antidepressants, and any prescription medication overlap.

For product decisions, prefer transparent labels, named extracts, clear serving sizes, and third-party quality testing. Avoid treating a long list of possible mechanisms as proof that an herb will solve a specific condition.