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Herb Profile
Raspberry Leaf
Rubus idaeus
Raspberry Leaf (Rubus idaeus) carries a Grade C rating — limited evidence.
Last reviewed: •3 sources citedReport a correctionProfile-wide ·C Limited
Use extra caution — Use during pregnancy only with obstetric supervision; avoid in high risk pregnancy, preterm labor risk, prior uterine surgery concerns, bleeding disorders, or concurrent uterotonic/labor inducing agents unless directed by a clinician. Details
- Evidence
- Limited Evidence
- Typical onset
- Varies by prep
- Safety rating
- High caution
- Best for
- Anti Inflammatory, Inflammatory signaling
- Avoid / review if
- High Risk Pregnancy, Early Pregnancy Without Clinician Guidance, History Of Preterm Labor
At a glance
From this profile's structured data- Evidence
- Grade C
- Safety
- Use during pregnancy only with obstetric supervision; avoid in high-risk pregnancy, preterm labor risk, prior uterine surgery concerns, bleeding disorders, or concurrent uterotonic/labor-inducing agents unless directed by a clinician.
- Profile context
- anti-inflammatory
Next stepsWhere to go next — guides & comparisons
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Safety
Safety & Cautions
Use during pregnancy only with obstetric supervision; avoid in high risk pregnancy, preterm labor risk, prior uterine surgery concerns, bleeding disorders, or concurrent uterotonic/labor inducing agents unless directed by a clinician.
High caution
Caution level: High. Multiple caution categories apply, or the record uses avoid/contraindication language.
- Interaction-AwareMedication or interaction context is explicitly noted.
- Anticoagulant CautionBleeding or anticoagulant-adjacent caution language is present.
Detailed safety fields
Pregnancy, breastfeeding, and contraindications
- High Risk Pregnancy
- Early Pregnancy Without Clinician Guidance
- History Of Preterm Labor
- Limited Interaction Data
- Caution With Uterotonic Agents Or Sedatives If Blended Products.
Safety classifications
- Interaction-Aware: Medication or interaction context is explicitly noted.
- Anticoagulant Caution: Bleeding or anticoagulant-adjacent caution language is present.
Full safety note
- Use during pregnancy only with obstetric supervision; avoid in high risk pregnancy, preterm labor risk, prior uterine surgery concerns, bleeding disorders, or concurrent uterotonic/labor inducing agents unless directed by a clinician.
Safety labels
- Interaction-Aware
- Anticoagulant Caution
Evidence-based safety
Caution when combined
Severity and certainty are shown separately. A high-priority caution can still be theoretical: these pairings are screened from shared contraindication mechanisms and are not automatically documented clinical interactions. Provenance identifies the source fields that produced each flag; it does not upgrade the certainty of the pairwise claim.
Moderate Caution
68 flagged pairingsSedation / CNS depression
Moderate Caution
68 flagged pairingsSedation / CNS depression
Representative pairings are shown below. Large mechanism groups are intentionally summarized to keep profiles focused and crawl-efficient.
Sedation / CNS depressionCertainty: Theoretical
Data provenance recorded for 68 of 68 pairings in this mechanism group.
- American Yellow Lotus — Theoretical interaction certainty
- Artemisia Absinthium — Theoretical interaction certainty
- Ashwagandha (Withania somnifera) — Theoretical interaction certainty
- Bacopa — Theoretical interaction certainty
- Black Seed — Theoretical interaction certainty
- Black Tea — Theoretical interaction certainty
- Blue Lotus — Theoretical interaction certainty
- Calamus — Theoretical interaction certainty
- Catuba — Theoretical interaction certainty
- Celastrus Paniculatus — Theoretical interaction certainty
- Chamomile — Theoretical interaction certainty
- Chinese Skullcap — Theoretical interaction certainty
+56 more pairings share this mechanism. Use the Safety Checker to review a specific combination.
Evidence
Evidence Summary
Evidence lens
Read as directional context, not settled clinical proof.
LimitedLimited Evidence
Human clinical evidence: Present in source signals
Mechanistic / preclinical: Mechanism mapped — Inflammatory Signaling Modulation · NF KB Modulation · Nrf2 Activation
Research maturity: Emerging research — Long Term Human Evidence May Be Limited.
Safety boundary: Safety note available — Use during pregnancy only with obstetric supervision; avoid in high risk pregnancy, preterm labor risk, prior uterine surgery concerns, bleeding disorders, or concurrent uterotonic/labor inducing agents unless directed b
This profile cites 3 human studies.
Study design details
Evidence Grade
Grade C: Limited Evidence
Evaluation of methodological rigor, population reach, and evidence alignment.
- Design Match
- Randomized controlled trial
- Risk of Bias
- Low
- Consistency
- Not assessed
Strongest recorded design is a randomized controlled trial, drawn from 3 recorded studies, 1 in people.
How evidence grades work
Each grade reflects the strength and consistency of published human evidence — not marketing claims. Grades are based on study count, design quality, effect size, consistency, and recency.
- Strong
- Multiple RCTs, consistent direction, adequate effect size
- Moderate
- Some RCTs or consistent observational data in humans
- Preliminary / Mixed
- Animal or in-vitro only, or conflicting human data
- Traditional / Theoretical
- Traditional use only; no controlled human trials
Clinical Study Summaries (3)1 human evidence source · 1 human trial · Participant totals not consistently reported · Consistency not yet classifiable
Filter by study class
Showing 3 of 3 studies.
What the evidence actually shows
This table contains 3 structured sources, including 1 human evidence source; 1 is a human trial.
| Study | Design | N | Dose | Duration | Population | Outcome | Result & magnitude | Source |
|---|---|---|---|---|---|---|---|---|
Rattanawiwatpong P et al. · J Cosmet Dermatol · 2020 Background | Randomized controlled trial Randomly assigns participants to interventions or controls, reducing many sources of bias when the trial is conducted well. | — | — | — | — | — | — | PubMed → |
PubMed indexed authors · 2006 Background | Narrative review Summarizes selected literature without the full prespecified search and selection methods of a systematic review. | — | — | — | — | — | — | PubMed → |
Known and Potential Invertebrate Vectors of Raspberry Viruses Tan JL et al. · Viruses · 2022 Background | Narrative review Summarizes selected literature without the full prespecified search and selection methods of a systematic review. | — | — | — | — | — | — | PubMed → |
Dosing & Timing
- No standardized dose
- Preparation specific; use standardized product label for Leaf tea/infusion and require source backed dosage review before therapeutic claims.
How Raspberry Leaf works
Simplified mechanism pathway based on preclinical and pharmacological evidence. Does not confirm clinical efficacy.
Mechanism Pathway — How Raspberry Leaf Works
CompoundTarget / ReceptorMechanismEffect / Outcome
Mechanisms & biological pathways (preclinical)
- Inflammatory Signaling Modulation
- NF KB Modulation
- Nrf2 Activation
Active Compounds
Key constituents studied in Raspberry Leaf, with full pharmacology and safety profiles.
Compare related active botanicals
Explore botanicals with similar chemistry, effects, or safety considerations in the Botanical Activity Atlas.
Guides that use Raspberry Leaf
Condition guides
Compare & Sourcing
Compare side-by-side tradeoffs or verify active marker guidelines.
Review available sources for Raspberry Leaf
Independent database mapping — evaluated separately from safety and efficacy scores.
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Safety first · Harm reduction
This information is educational and not medical advice. Start low, avoid risky combinations, and consult a licensed clinician before making health decisions—especially if you use medications, have diagnosed conditions, or are pregnant/breastfeeding.
Learn how we evaluate confidence, safety, and intensity on the methodology page.
Editorial Review
Checked against primary sources, cited evidence, and contraindication language before publication. Evidence claims, safety language, and affiliate modules are reviewed independently. Not personal medical advice.
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