Herb Profile

Sage

Salvia officinalis

Sage (Salvia officinalis) carries a Grade C rating — limited evidence.

Last reviewed: •3 sources citedReport a correctionProfile-wide ·C Limited

Use extra caution — Generally well tolerated; review concentrated extract use. Details

Evidence
Limited Evidence
Typical onset
Varies by prep
Safety rating
Moderate caution
Best for
Cognitive Support, Antimicrobial, Anti Inflammatory, Stress
Avoid / review if
Pregnancy, Seizure Disorder, High Dose Essential Oil Use
Sage monograph visual
The Hippie Scientist

At a glance

From this profile's structured data
Evidence
Grade C
Safety
Generally well tolerated; review concentrated extract use.
Profile context
cognitive_support, antimicrobial, anti_inflammatory
Next steps

Continue reading

Safety

Safety & Cautions

Generally well tolerated; review concentrated extract use.

Elevated caution

Caution level: Elevated. One caution category applies — read it before use.

  • Pregnancy/Breastfeeding CautionPregnancy or breastfeeding caution language is present.
Detailed safety fields

Pregnancy, breastfeeding, and contraindications

  • Pregnancy
  • Seizure Disorder
  • High Dose Essential Oil Use
  • Breastfeeding Where Milk Suppression Is A Concern
  • May Interact With Sedatives
  • Anticonvulsants
  • Antidiabetics
  • Or Cholinergic/Anticholinergic Drugs Depending Preparation.

Safety classifications

  • Pregnancy/Breastfeeding Caution: Pregnancy or breastfeeding caution language is present.

Full safety note

  • Generally well tolerated; review concentrated extract use.

Safety labels

  • Pregnancy/Breastfeeding Caution

Evidence-based safety

Caution when combined

Severity and certainty are shown separately. A high-priority caution can still be theoretical: these pairings are screened from shared contraindication mechanisms and are not automatically documented clinical interactions. Provenance identifies the source fields that produced each flag; it does not upgrade the certainty of the pairwise claim.

Moderate Caution

178 flagged pairings

Blood-sugar lowering · Sedation / CNS depression

Representative pairings are shown below. Large mechanism groups are intentionally summarized to keep profiles focused and crawl-efficient.

Blood-sugar loweringCertainty: Theoretical

Data provenance recorded for 110 of 110 pairings in this mechanism group.

+98 more pairings share this mechanism. Use the Safety Checker to review a specific combination.

Sedation / CNS depressionCertainty: Theoretical

Data provenance recorded for 68 of 68 pairings in this mechanism group.

+56 more pairings share this mechanism. Use the Safety Checker to review a specific combination.

Evidence

Evidence Summary

Evidence lens

Read as directional context, not settled clinical proof.

LimitedLimited Evidence

Human clinical evidence: Not the primary signal

Mechanistic / preclinical: Mechanism mapped — Inflammatory Signaling Modulation · Oxidative Stress Modulation · Stress Response Modulation

Research maturity: Theoretical / mechanistic research — Mechanistic or unresolved evidence is kept separate from established human outcomes.

Safety boundary: Safety note available — Generally well tolerated; review concentrated extract use.

This profile cites 3 human studies.

Study design details
Evidence Grade

Grade C: Limited Evidence

Evaluation of methodological rigor, population reach, and evidence alignment.

Design Match
Narrative review
Risk of Bias
High
Consistency
Not assessed
Strongest recorded design is a narrative review, drawn from 2 recorded studies, none of which measured an outcome in people.
How evidence grades work

Each grade reflects the strength and consistency of published human evidence — not marketing claims. Grades are based on study count, design quality, effect size, consistency, and recency.

Strong
Multiple RCTs, consistent direction, adequate effect size
Moderate
Some RCTs or consistent observational data in humans
Preliminary / Mixed
Animal or in-vitro only, or conflicting human data
Traditional / Theoretical
Traditional use only; no controlled human trials
Clinical Study Summaries (3)0 human evidence sources · 0 human trials · Participant totals not consistently reported · Consistency not yet classifiable

Filter by study class

Showing 3 of 3 studies.

What the evidence actually shows

This table contains 3 structured sources, including 0 human evidence sources; 0 are human trials.

StudyDesignNDoseDurationPopulationOutcomeResult & magnitudeSource

Huntington's disease clinical trials update: March 2025

Farag M et al. · J Huntingtons Dis · 2025

Background
Narrative review

Summarizes selected literature without the full prespecified search and selection methods of a systematic review.

——————PubMed →

A review of effective herbal medicines in controlling menopausal symptoms

Kargozar R et al. · Electron Physician · 2017

Background
Narrative review

Summarizes selected literature without the full prespecified search and selection methods of a systematic review.

——————PubMed →

Pharmacological properties of Salvia officinalis and its components

Ghorbani A et al. · J Tradit Complement Med · 2017

Background
Other / unclear

The study design is not yet classified clearly enough to infer its place in the evidence hierarchy.

——————PubMed →

Dosing & Timing

No standardized dose
Preparation specific; use standardized product label for Leaf tea and require source backed dosage review before therapeutic claims.
How Sage works

Simplified mechanism pathway based on preclinical and pharmacological evidence. Does not confirm clinical efficacy.

Mechanism Pathway — How Sage Works

How Sage WorksSage acts on biological target pathways via anti inflammatory, leading to cognitive support.SageBiological TargetBiological pathwayAnti InflammatoryCognitive SupportObservable outcomeAntioxidantParallel pathway
CompoundTarget / ReceptorMechanismEffect / Outcome
Mechanisms & biological pathways (preclinical)
  • Inflammatory Signaling Modulation
  • Oxidative Stress Modulation
  • Stress Response Modulation
  • Neuroprotective Activity
  • AMPK Signaling
  • NF KB Modulation

Active Compounds

Key constituents studied in Sage, with full pharmacology and safety profiles.

Compare related active botanicals

Explore botanicals with similar chemistry, effects, or safety considerations in the Botanical Activity Atlas.

Guides that use Sage

Condition guides

Compare & Sourcing

Compare side-by-side tradeoffs or verify active marker guidelines.

Safety first · Harm reduction

This information is educational and not medical advice. Start low, avoid risky combinations, and consult a licensed clinician before making health decisions—especially if you use medications, have diagnosed conditions, or are pregnant/breastfeeding.

Learn how we evaluate confidence, safety, and intensity on the methodology page.

Editorial Review

Checked against primary sources, cited evidence, and contraindication language before publication. Evidence claims, safety language, and affiliate modules are reviewed independently. Not personal medical advice.

Editorial Standards →

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