Related Compounds
Compounds connected by the same goals, effects, or research topics.
Compound Profile
Celastrol
Quinone methide triterpenoid from Thunder God Vine (Tripterygium wilfordii) with potent NF κB and HSP90 inhibitory activity.
Use extra caution — High caution compound with narrow therapeutic window in preclinical literature. Details
Last reviewed: Report a correctionProfile-wide ·C Limited
At a glance
From this profile's structured data- Evidence
- Grade C
- Safety
- High-caution compound with narrow therapeutic window in preclinical literature.
- Profile context
- HSP90, NF-κB, proteasome/stress-response pathways
Next stepsWhere to go next — guides & comparisons
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Quick stats
- Evidence level
- Limited evidence
- Typical onset
- Varies by prep
- Safety rating
- Use extra caution: Use caution
- Best for
- HSP90, NF κB, Proteasome/Stress Response Pathways
- Avoid / review if
- Pregnancy, Liver, Kidney
Botanical Context
Source botanicals and comparison guides related to Celastrol.
Found in
Safety
Safety & Cautions
High caution compound with narrow therapeutic window in preclinical literature. Do not infer supplement safety; avoid pregnancy, liver/kidney disease, and unsupervised use.
High caution
Caution level: High. Multiple caution categories apply, or the record uses avoid/contraindication language.
- Liver-SensitiveLiver-related caution language appears in the profile.
Evidence Summary
Profile-wide ·C LimitedEvidence lens
Read as directional context, not settled clinical proof.
LimitedLimited evidence
Human clinical evidence: Not the primary signal
Mechanistic / preclinical: Mechanism mapped — Heat Shock Response Modulation · Stress Response Modulation · NF KB Modulation
Research maturity: Theoretical / mechanistic research — Mechanistic or unresolved evidence is kept separate from established human outcomes.
Safety boundary: Safety note available — High caution compound with narrow therapeutic window in preclinical literature.
Evidence Strength
Confidence estimate based on the design quality and consistency of published clinical trials.
Celastrol has a limited evidence rating.
AdaptogenStress & Mood
Effects
5
Evidence Grade
Grade C: Limited Evidence
Evaluation of methodological rigor, population reach, and evidence alignment.
- Design Match
- Meta analysis
- Risk of Bias
- Low
- Consistency
- Not assessed
Strongest recorded design is a meta analysis, drawn from 1 recorded study, 1 in people.
How evidence grades work
Each grade reflects the strength and consistency of published human evidence — not marketing claims. Grades are based on study count, design quality, effect size, consistency, and recency.
- Strong
- Multiple RCTs, consistent direction, adequate effect size
- Moderate
- Some RCTs or consistent observational data in humans
- Preliminary / Mixed
- Animal or in-vitro only, or conflicting human data
- Traditional / Theoretical
- Traditional use only; no controlled human trials
How Celastrol Works
Simplified mechanism pathway based on preclinical and pharmacological evidence. Does not confirm clinical efficacy.
Mechanism Pathway — How Celastrol Works
CompoundTarget / ReceptorMechanismEffect / Outcome
Dosing
- Common form
- capsule or standardized extract
- No standardized dose
- Our source data records the usual product form for this ingredient but no studied dose. Preparations differ widely, so follow the standardization on the product you actually have and speak to a clinician before starting.
Mechanisms & biological pathways
Preclinical mechanism details from scientific profiles; these represent plausible pathways but do not guarantee clinical efficacy in humans.
- Heat Shock Response Modulation
- Stress Response Modulation
- NF KB Modulation
- HSP90 Inhibition
- Inflammatory Signaling Modulation
- NF κB Pathway Suppression
Continue exploring
Related research paths
Related Herbs
Botanicals connected by the same goals, effects, or research topics.
Related Guides
Deeper context, comparisons, and practical research paths.
Related Articles
Deeper context, comparisons, and practical research paths.
Compare & Sourcing
Compare side-by-side tradeoffs or verify active marker guidelines.
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Safety first · Harm reduction
This information is educational and not medical advice. Start low, avoid risky combinations, and consult a licensed clinician before making health decisions—especially if you use medications, have diagnosed conditions, or are pregnant/breastfeeding.
Learn how we evaluate confidence, safety, and intensity on the methodology page.
Editorial Review
Checked against primary sources, cited evidence, and contraindication language before publication. Evidence claims, safety language, and affiliate modules are reviewed independently. Not personal medical advice.
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