Related Compounds
Compounds connected by the same goals, effects, or research topics.
Compound Profile
Cryptotanshinone
Abietane diterpenoid from Salvia miltiorrhiza (Danshen) root with JAK2/STAT3 inhibitory and anti inflammatory properties.
Use extra caution — Danshen constituents may affect bleeding and cardiovascular medications; use clinician review with anticoagulants/antiplatelets. Details
Last reviewed: •1 source citedReport a correctionProfile-wide ·C Limited
At a glance
From this profile's structured data- Evidence
- Grade C
- Safety
- Danshen constituents may affect bleeding and cardiovascular medications; use clinician review with anticoagulants/antiplatelets.
- Profile context
- NF-κB, MAPK, platelet aggregation
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Quick stats
- Evidence level
- Limited evidence
- Typical onset
- Varies by prep
- Safety rating
- Use extra caution: Use caution
- Best for
- NF κB, MAPK, Platelet Aggregation
Botanical Context
Source botanicals and comparison guides related to Cryptotanshinone.
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Safety
Safety & Cautions
Danshen constituents may affect bleeding and cardiovascular medications; use clinician review with anticoagulants/antiplatelets.
High caution
Caution level: High. Multiple caution categories apply, or the record uses avoid/contraindication language.
- Interaction-AwareMedication or interaction context is explicitly noted.
- Hormonal Activity ContextHormone-adjacent wording is present and should be interpreted carefully.
- Stimulant-Like ProfileStimulant-like or activating caution language is present.
- Anticoagulant CautionBleeding or anticoagulant-adjacent caution language is present.
Evidence-based safety
Caution when combined
Severity and certainty are shown separately. A high-priority caution can still be theoretical: these pairings are screened from shared contraindication mechanisms and are not automatically documented clinical interactions. Provenance identifies the source fields that produced each flag; it does not upgrade the certainty of the pairwise claim.
High-Priority Caution
147 flagged pairingsBleeding / anticoagulant risk
High-Priority Caution
147 flagged pairingsBleeding / anticoagulant risk
Representative pairings are shown below. Large mechanism groups are intentionally summarized to keep profiles focused and crawl-efficient.
Bleeding / anticoagulant riskCertainty: Theoretical
Data provenance recorded for 147 of 147 pairings in this mechanism group.
- aescin — Theoretical interaction certainty
- Aged Garlic Extract — Theoretical interaction certainty
- ajoene — Theoretical interaction certainty
- Ajwain — Theoretical interaction certainty
- Allicin — Theoretical interaction certainty
- Garlic — Theoretical interaction certainty
- American Ginseng Extract — Theoretical interaction certainty
- Andrographis — Theoretical interaction certainty
- Angelica Archangelica — Theoretical interaction certainty
- Angelica Dahurica — Theoretical interaction certainty
- Angelica Pubescens — Theoretical interaction certainty
- Angelica Root — Theoretical interaction certainty
+135 more pairings share this mechanism. Use the Safety Checker to review a specific combination.
Evidence Summary
Profile-wide ·C LimitedEvidence lens
Read as directional context, not settled clinical proof.
LimitedLimited evidence
Human clinical evidence: Not the primary signal
Mechanistic / preclinical: Mechanism mapped — Inflammatory Signaling Modulation · Vascular Function Support · NF KB Modulation
Research maturity: Theoretical / mechanistic research — Mechanistic or unresolved evidence is kept separate from established human outcomes.
Safety boundary: Safety note available — Danshen constituents may affect bleeding and cardiovascular medications; use clinician review with anticoagulants/antiplatelets.
This profile cites 1 human study.
Evidence Strength
Confidence estimate based on the design quality and consistency of published clinical trials.
Cryptotanshinone has a limited evidence rating.
General wellnessGeneral wellness
Citation density
0.3
Sources
1
Effects
4
Research recency
Mixed recency
How evidence grades work
Each grade reflects the strength and consistency of published human evidence — not marketing claims. Grades are based on study count, design quality, effect size, consistency, and recency.
- Strong
- Multiple RCTs, consistent direction, adequate effect size
- Moderate
- Some RCTs or consistent observational data in humans
- Preliminary / Mixed
- Animal or in-vitro only, or conflicting human data
- Traditional / Theoretical
- Traditional use only; no controlled human trials
Clinical Study Summaries (1)0 human evidence sources · 0 human trials · Participant totals not consistently reported · Consistency not yet classifiable
What the evidence actually shows
This table contains 1 structured source, including 0 human evidence sources; 0 are human trials.
| Study | Design | N | Dose | Duration | Population | Outcome | Result & magnitude | Source |
|---|---|---|---|---|---|---|---|---|
Wang T et al. · Biomed Pharmacother · 2024 Background | Other / unclear The study design is not yet classified clearly enough to infer its place in the evidence hierarchy. | — | — | — | — | — | — | PubMed → |
How Cryptotanshinone Works
Simplified mechanism pathway based on preclinical and pharmacological evidence. Does not confirm clinical efficacy.
Mechanism Pathway — How Cryptotanshinone Works
CompoundTarget / ReceptorMechanismEffect / Outcome
Dosing
- Common form
- capsule or standardized extract
- No standardized dose
- Our source data records the usual product form for this ingredient but no studied dose. Preparations differ widely, so follow the standardization on the product you actually have and speak to a clinician before starting.
Mechanisms & biological pathways
Preclinical mechanism details from scientific profiles; these represent plausible pathways but do not guarantee clinical efficacy in humans.
- Inflammatory Signaling Modulation
- Vascular Function Support
- NF KB Modulation
- Inflammatory
Guides that use Cryptotanshinone
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Compare & Sourcing
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Safety first · Harm reduction
This information is educational and not medical advice. Start low, avoid risky combinations, and consult a licensed clinician before making health decisions—especially if you use medications, have diagnosed conditions, or are pregnant/breastfeeding.
Learn how we evaluate confidence, safety, and intensity on the methodology page.
Editorial Review
Checked against primary sources, cited evidence, and contraindication language before publication. Evidence claims, safety language, and affiliate modules are reviewed independently. Not personal medical advice.
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