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Herb Profile
Angelica Archangelica
Angelica archangelica
Angelica Archangelica (Angelica archangelica) carries a Grade C rating — limited evidence.
Last reviewed: •3 sources citedReport a correctionProfile-wide ·C Limited
Use extra caution — May affect bleeding risk or circulation. Details
- Evidence
- Limited Evidence
- Typical onset
- Varies by prep
- Safety rating
- High caution
- Best for
- Digestive, Respiratory, Antimicrobial, Inflammatory signaling
- Avoid / review if
- Pregnancy/Breastfeeding Without Clinician Supervision, Known Allergy To The Plant/Family, Bleeding Disorder Or Upcoming Surgery
At a glance
From this profile's structured data- Evidence
- Grade C
- Safety
- May affect bleeding risk or circulation.
- Profile context
- digestive, respiratory, antimicrobial
Next stepsWhere to go next — guides & comparisons
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Safety
Safety & Cautions
May affect bleeding risk or circulation. Use caution with anticoagulants/antiplatelets and before surgery.
High caution
Caution level: High. Multiple caution categories apply, or the record uses avoid/contraindication language.
- Interaction-AwareMedication or interaction context is explicitly noted.
- Anticoagulant CautionBleeding or anticoagulant-adjacent caution language is present.
- Pregnancy/Breastfeeding CautionPregnancy or breastfeeding caution language is present.
Detailed safety fields
Pregnancy, breastfeeding, and contraindications
- Pregnancy/Breastfeeding Without Clinician Supervision
- Known Allergy To The Plant/Family
- Bleeding Disorder Or Upcoming Surgery
- Potential Interaction Concern With Anticoagulants/Antiplatelets
- Immunosuppressants
- Use Clinician Review For High Dose Extracts Or Chronic Use.
Safety classifications
- Interaction-Aware: Medication or interaction context is explicitly noted.
- Anticoagulant Caution: Bleeding or anticoagulant-adjacent caution language is present.
- Pregnancy/Breastfeeding Caution: Pregnancy or breastfeeding caution language is present.
Full safety note
- May affect bleeding risk or circulation. Use caution with anticoagulants/antiplatelets and before surgery.
Safety labels
- Interaction-Aware
- Anticoagulant Caution
- Pregnancy/Breastfeeding Caution
Evidence-based safety
Caution when combined
Severity and certainty are shown separately. A high-priority caution can still be theoretical: these pairings are screened from shared contraindication mechanisms and are not automatically documented clinical interactions. Provenance identifies the source fields that produced each flag; it does not upgrade the certainty of the pairwise claim.
High-Priority Caution
147 flagged pairingsBleeding / anticoagulant risk
High-Priority Caution
147 flagged pairingsBleeding / anticoagulant risk
Representative pairings are shown below. Large mechanism groups are intentionally summarized to keep profiles focused and crawl-efficient.
Bleeding / anticoagulant riskCertainty: Theoretical
Data provenance recorded for 147 of 147 pairings in this mechanism group.
- aescin — Theoretical interaction certainty
- Aged Garlic Extract — Theoretical interaction certainty
- ajoene — Theoretical interaction certainty
- Ajwain — Theoretical interaction certainty
- Allicin — Theoretical interaction certainty
- Garlic — Theoretical interaction certainty
- American Ginseng Extract — Theoretical interaction certainty
- Andrographis — Theoretical interaction certainty
- Angelica Dahurica — Theoretical interaction certainty
- Angelica Pubescens — Theoretical interaction certainty
- Angelica Root — Theoretical interaction certainty
- Angelica Sinensis — Theoretical interaction certainty
+135 more pairings share this mechanism. Use the Safety Checker to review a specific combination.
Evidence
Evidence Summary
Evidence lens
Read as directional context, not settled clinical proof.
LimitedLimited Evidence
Human clinical evidence: Not the primary signal
Mechanistic / preclinical: Mechanism mapped — NF KB Modulation · Nrf2 Activation
Research maturity: Theoretical / mechanistic research — Mechanistic or unresolved evidence is kept separate from established human outcomes.
Safety boundary: Safety note available — May affect bleeding risk or circulation.
This profile cites 3 human studies.
Study design details
Evidence Grade
Grade C: Limited Evidence
Evaluation of methodological rigor, population reach, and evidence alignment.
- Design Match
- Narrative review
- Risk of Bias
- High
- Consistency
- Not assessed
Strongest recorded design is a narrative review, drawn from 1 recorded study, none of which measured an outcome in people.
How evidence grades work
Each grade reflects the strength and consistency of published human evidence — not marketing claims. Grades are based on study count, design quality, effect size, consistency, and recency.
- Strong
- Multiple RCTs, consistent direction, adequate effect size
- Moderate
- Some RCTs or consistent observational data in humans
- Preliminary / Mixed
- Animal or in-vitro only, or conflicting human data
- Traditional / Theoretical
- Traditional use only; no controlled human trials
Clinical Study Summaries (3)0 human evidence sources · 0 human trials · Participant totals not consistently reported · Consistency not yet classifiable
Filter by study class
Showing 3 of 3 studies.
What the evidence actually shows
This table contains 3 structured sources, including 0 human evidence sources; 0 are human trials. A reliable participant total cannot be calculated because sample size is not consistently structured in the cited sources. Source-to-conclusion relationships are not classified in this structured set, so consistency is not yet classifiable.
Profile-wide evidence grade: see the profile grade above · Confidence: not separately assigned
What would change our conclusion?
Larger, well-controlled human trials using comparable populations, doses, preparations, and clinically meaningful outcomes could materially strengthen or weaken this conclusion. Replication in a different population or a high-quality synthesis resolving current disagreement could also materially change confidence.
| Study | Design | N | Dose | Duration | Population | Outcome | Result & magnitude | Source |
|---|---|---|---|---|---|---|---|---|
Awareness and current knowledge of epilepsy Khan AU et al. · Metab Brain Dis · 2020 Background | Narrative review Summarizes selected literature without the full prespecified search and selection methods of a systematic review. | — | — | — | — | — | — | PubMed → |
Coumarins from Angelica archangelica Linn. and their effects on anxiety-like behavior Kumar D et al. · Prog Neuropsychopharmacol Biol Psychiatry · 2013 Background | Other / unclear The study design is not yet classified clearly enough to infer its place in the evidence hierarchy. | — | — | — | — | — | — | PubMed → |
Kaur A et al. · J Food Sci · 2020 Background | Other / unclear The study design is not yet classified clearly enough to infer its place in the evidence hierarchy. | — | — | — | — | — | — | PubMed → |
Dosing & Timing
- No standardized dose
- Preparation specific; use standardized product label for Preparation varies by tradition and product form and require source backed dosage review before therapeutic claims.
How Angelica Archangelica works
Simplified mechanism pathway based on preclinical and pharmacological evidence. Does not confirm clinical efficacy.
Mechanism Pathway — How Angelica Archangelica Works
CompoundTarget / ReceptorMechanismEffect / Outcome
Mechanisms & biological pathways
Preclinical pathways. Proposed mechanisms from in vitro and animal research; these do not confirm clinical outcomes in humans.
- NF KB Modulation
- Nrf2 Activation
Active Compounds
Key constituents studied in Angelica Archangelica, with full pharmacology and safety profiles.
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Guides that use Angelica Archangelica
Condition guides
Compare & Sourcing
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Safety first · Harm reduction
This information is educational and not medical advice. Start low, avoid risky combinations, and consult a licensed clinician before making health decisions—especially if you use medications, have diagnosed conditions, or are pregnant/breastfeeding.
Learn how we evaluate confidence, safety, and intensity on the methodology page.
Editorial Review
Checked against primary sources, cited evidence, and contraindication language before publication. Evidence claims, safety language, and affiliate modules are reviewed independently. Not personal medical advice.
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Botanical profile context
How to interpret Angelica Archangelica
Angelica Archangelica herb profile with evidence context, key research topics, source notes, safety context, and references presented in an evidence-first… Use this herb profile as a starting point for evidence review, not as a recommendation to start a new supplement. Botanical products can vary by plant part, extract ratio, standardization, dose, and contaminant testing, so two labels with the same common name may not behave the same way.
When reviewing Angelica Archangelica, compare the traditional-use context against the human evidence, mechanism notes, and safety cautions. Pay special attention to pregnancy, breastfeeding, liver or kidney disease, blood-pressure effects, sedation, stimulation, anticoagulant use, antidepressants, and any prescription medication overlap.
For product decisions, prefer transparent labels, named extracts, clear serving sizes, and third-party quality testing. Avoid treating a long list of possible mechanisms as proof that an herb will solve a specific condition.