Compound Profile
Rosmarinic Acid
Rosmarinic acid is a caffeic acid ester abundant in rosemary, lemon balm, perilla, and other Lamiaceae herbs.
Last reviewed: Report a correctionProfile-wide ·C Limited
Use extra caution — Food/herb exposure is generally low risk; isolated high dose safety is less established. Details
- Evidence
- Limited evidence
- Typical onset
- Varies by prep
- Safety rating
- Use extra caution: Use caution
- Best for
- NF κB, Nrf2, Complement And Inflammatory Signaling
- Avoid / review if
- Pregnancy
Safety
Safety & Cautions
Food/herb exposure is generally low risk; isolated high dose safety is less established. Caution with pregnancy, anticoagulant use, and complex immune therapy contexts.
Elevated caution
Caution level: Elevated. One caution category applies — read it before use.
Evidence Summary
Profile-wide ·C LimitedEvidence lens
Read as directional context, not settled clinical proof.
LimitedLimited evidence
Human clinical evidence: Not the primary signal
Mechanistic / preclinical: Mechanism mapped — COX 2 And LOX Modulation (Preclinical) · Neurotransmitter Modulation · Antioxidant Activity
Research maturity: Theoretical / mechanistic research — Mechanistic or unresolved evidence is kept separate from established human outcomes.
Safety boundary: Safety note available — Food/herb exposure is generally low risk; isolated high dose safety is less established.
Evidence Strength
Confidence estimate based on the design quality and consistency of published clinical trials.
Rosmarinic Acid has a limited evidence rating.
AdaptogenStress & MoodLongevity
Effects
4
How evidence grades work
Each grade reflects the strength and consistency of published human evidence — not marketing claims. Grades are based on study count, design quality, effect size, consistency, and recency.
- Strong
- Multiple RCTs, consistent direction, adequate effect size
- Moderate
- Some RCTs or consistent observational data in humans
- Preliminary / Mixed
- Animal or in-vitro only, or conflicting human data
- Traditional / Theoretical
- Traditional use only; no controlled human trials
How Rosmarinic Acid Works
Simplified mechanism pathway based on preclinical and pharmacological evidence. Does not confirm clinical efficacy.
Mechanism Pathway — How Rosmarinic Acid Works
CompoundTarget / ReceptorMechanismEffect / Outcome
Dosing
- Common form
- capsule or standardized extract
- No standardized dose
- Our source data records the usual product form for this ingredient but no studied dose. Preparations differ widely, so follow the standardization on the product you actually have and speak to a clinician before starting.
Mechanisms & biological pathways
Preclinical mechanism details from scientific profiles; these represent plausible pathways but do not guarantee clinical efficacy in humans.
- COX 2 And LOX Modulation (Preclinical)
- Neurotransmitter Modulation
- Antioxidant Activity
- NF KB Inhibition
- Nrf2 Activation
- Mitochondrial Support
Botanical Context
Source botanicals and comparison guides related to Rosmarinic Acid.
Found in
Compare active botanicals
Compare & Sourcing
Compare side-by-side tradeoffs or verify active marker guidelines.
Safety first · Harm reduction
This information is educational and not medical advice. Start low, avoid risky combinations, and consult a licensed clinician before making health decisions—especially if you use medications, have diagnosed conditions, or are pregnant/breastfeeding.
Learn how we evaluate confidence, safety, and intensity on the methodology page.
Founder & Head Researcher · Oak Ridge, TN · Last reviewed August 2026
Editorial Review
Checked against primary sources, cited evidence, and contraindication language before publication. Evidence claims, safety language, and affiliate modules are reviewed independently. Not personal medical advice.
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