Herb Profile
Plumbago Zeylanica
Botanical profile with evidence, safety, and practical fit.
Last reviewed: •3 human studies cited
C PreliminaryUse extra caution — Irritant naphthoquinones may damage mucosa/skin at high exposure. Details
- Evidence
- Limited Human Evidence
- Typical onset
- Varies by prep
- Safety rating
- High caution
- Best for
- Anti Inflammatory, Digestive Support, Antimicrobial, Stress resilience
- Avoid / review if
- Pregnancy/Breastfeeding Without Clinician Supervision, Known Allergy To The Plant/Family, Potential Interaction Concern With Immunosuppressants
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Plumbago Zeylanica
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Safety & Cautions
Irritant naphthoquinones may damage mucosa/skin at high exposure. Avoid pregnancy and internal high dose use.
28%
High caution — review carefully
Detailed safety fields
Pregnancy, breastfeeding, and contraindications
- - Pregnancy/Breastfeeding Without Clinician Supervision
- - Known Allergy To The Plant/Family
- - Potential Interaction Concern With Immunosuppressants
- - Use Clinician Review For High Dose Extracts Or Chronic Use.
Safety classifications
- - Interaction-Aware: Medication or interaction context is explicitly noted.
- - Pregnancy/Breastfeeding Caution: Pregnancy or breastfeeding caution language is present.
Full safety note
- - Irritant naphthoquinones may damage mucosa/skin at high exposure. Avoid pregnancy and internal high dose use.
Safety labels
- - Interaction-Aware
- - Pregnancy/Breastfeeding Caution
Evidence Summary
Evidence lens
Early signal that needs stronger human replication before practical claims.
PreliminaryLimited Human Evidence
Human clinical evidence: Present in source signals
Mechanistic / preclinical: Mechanism mapped — Oxidative Stress Modulation · NF KB Modulation
Research maturity: Preliminary or mixed — Long Term Human Evidence May Be Limited.
Safety boundary: Safety note available — Irritant naphthoquinones may damage mucosa/skin at high exposure.
This profile cites 3 human studies.
How evidence grades work
Each grade reflects the strength and consistency of published human evidence — not marketing claims. Grades are based on study count, design quality, effect size, consistency, and recency.
A
Strong
Multiple RCTs, consistent direction, adequate effect size
B
Moderate
Some RCTs or consistent observational data in humans
C
Preliminary / Mixed
Animal or in-vitro only, or conflicting human data
D
Traditional / Theoretical
Traditional use only; no controlled human trials
Clinical Study Summaries (3)Cited studies informing this profile. RCTs and reviews shown first.
| Study | Type | Sample | Source |
|---|---|---|---|
Liu Z et al. (2024) | — | — | PubMed → |
Zhang X et al. (2024) | — | — | PubMed → |
Plumbagin alleviates muscle atrophy in female mice through inhibiting the DANCR/NF-κB axis Liu Y et al. (2025) | — | — | PubMed → |
Dosing & Timing
Dose guidance
Preparation specific; use standardized product label for Preparation varies by tradition and product form and require source backed dosage review before therapeutic claims.
How Plumbago Zeylanica Works
Simplified mechanism pathway based on preclinical and pharmacological evidence. Does not confirm clinical efficacy.
Mechanism Pathway — How Plumbago Zeylanica Works
CompoundTarget / ReceptorMechanismEffect / Outcome
Mechanisms & Biological Pathways
Preclinical pathways
Proposed mechanisms from in vitro and animal research; these do not confirm clinical outcomes in humans.
Oxidative Stress ModulationNF KB Modulation
Active Compounds
Key constituents studied in Plumbago Zeylanica, with full pharmacology and safety profiles.
Condition guides
Compare & Sourcing
Compare side-by-side tradeoffs or verify active marker guidelines.
Review available sources for Plumbago Zeylanica
Independent database mapping — evaluated separately from safety and efficacy scores.
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Safety first · Harm reduction
This information is educational and not medical advice. Start low, avoid risky combinations, and consult a licensed clinician before making health decisions—especially if you use medications, have diagnosed conditions, or are pregnant/breastfeeding.
Learn how we evaluate confidence, safety, and intensity on the methodology page.
Editorial Review
Checked against primary sources, cited evidence, and contraindication language before publication. Evidence claims, safety language, and affiliate modules are reviewed independently. Not personal medical advice.
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Botanical profile context
How to interpret Plumbago Zeylanica
Plumbago Zeylanica dosage ranges, effects, drug interactions, and harm-reduction safety guide for anti inflammatory. Limited Human Evidence research evidence. Use this herb profile as a starting point for evidence review, not as a recommendation to start a new supplement. Botanical products can vary by plant part, extract ratio, standardization, dose, and contaminant testing, so two labels with the same common name may not behave the same way.
When reviewing Plumbago Zeylanica, compare the traditional-use context against the human evidence, mechanism notes, and safety cautions. Pay special attention to pregnancy, breastfeeding, liver or kidney disease, blood-pressure effects, sedation, stimulation, anticoagulant use, antidepressants, and any prescription medication overlap.
For product decisions, prefer transparent labels, named extracts, clear serving sizes, and third-party quality testing. Avoid treating a long list of possible mechanisms as proof that an herb will solve a specific condition.