Herb Profile
Reishi Ganoderma Lucidum
Ganoderma lucidum
Educational page may discuss mechanistic interest only.
Last reviewed: •2 sources citedReport a correctionProfile-wide ·D Preliminary
Use extra caution — May increase bleeding risk when combined with anticoagulants, antiplatelets, or aspirin, and can oppose immunosuppressant medications used post transplant or for autoimmune disease. Details
- Evidence
- Preliminary Evidence
- Typical onset
- Varies by prep
- Safety rating
- High caution
- Best for
- Sleep, Stress, Inflammatory signaling
- Avoid / review if
- Autoimmune Conditions (Caution), Bleeding Disorders, Anticoagulants
Safety
Safety & Cautions
May increase bleeding risk when combined with anticoagulants, antiplatelets, or aspirin, and can oppose immunosuppressant medications used post transplant or for autoimmune disease. Existing liver disease is a caution requiring medical supervision; rare liver enzyme elevation has been reported mainly at very high, prolonged doses.
High caution
Caution level: High. Multiple caution categories apply, or the record uses avoid/contraindication language.
- Liver-SensitiveLiver-related caution language appears in the profile.
- Anticoagulant CautionBleeding or anticoagulant-adjacent caution language is present.
Detailed safety fields
Pregnancy, breastfeeding, and contraindications
- Autoimmune Conditions (Caution)
- Bleeding Disorders
- Anticoagulants
- Immunosuppressants
Safety classifications
- Liver-Sensitive: Liver-related caution language appears in the profile.
- Anticoagulant Caution: Bleeding or anticoagulant-adjacent caution language is present.
Full safety note
- May increase bleeding risk when combined with anticoagulants, antiplatelets, or aspirin, and can oppose immunosuppressant medications used post transplant or for autoimmune disease. Existing liver disease is a caution requiring medical supervision; rare liver enzyme elevation has been reported mainly at very high, prolonged doses. Mild dizziness, GI upset, or skin irritation are the most common side effects.
Safety labels
- Liver-Sensitive
- Anticoagulant Caution
Evidence-based safety
Caution when combined
Severity and certainty are shown separately. A high-priority caution can still be theoretical: these pairings are screened from shared contraindication mechanisms and are not automatically documented clinical interactions. Provenance identifies the source fields that produced each flag; it does not upgrade the certainty of the pairwise claim.
High-Priority Caution
147 flagged pairingsBleeding / anticoagulant risk
High-Priority Caution
147 flagged pairingsBleeding / anticoagulant risk
Representative pairings are shown below. Large mechanism groups are intentionally summarized to keep profiles focused and crawl-efficient.
Bleeding / anticoagulant riskCertainty: Theoretical
Data provenance recorded for 147 of 147 pairings in this mechanism group.
- aescin — Theoretical interaction certainty
- Aged Garlic Extract — Theoretical interaction certainty
- ajoene — Theoretical interaction certainty
- Ajwain — Theoretical interaction certainty
- Allicin — Theoretical interaction certainty
- Garlic — Theoretical interaction certainty
- American Ginseng Extract — Theoretical interaction certainty
- Andrographis — Theoretical interaction certainty
- Angelica Archangelica — Theoretical interaction certainty
- Angelica Dahurica — Theoretical interaction certainty
- Angelica Pubescens — Theoretical interaction certainty
- Angelica Root — Theoretical interaction certainty
+135 more pairings share this mechanism. Use the Safety Checker to review a specific combination.
Evidence
Evidence Summary
Evidence lens
Early signal that needs stronger human replication before practical claims.
PreliminaryPreliminary Evidence
Human clinical evidence: Not the primary signal
Mechanistic / preclinical: Mechanism mapped — Inflammatory Signaling Modulation · Oxidative Stress Modulation · Immune Signaling Modulation
Research maturity: Theoretical / mechanistic research — Mechanistic or unresolved evidence is kept separate from established human outcomes.
Safety boundary: Safety note available — May increase bleeding risk when combined with anticoagulants, antiplatelets, or aspirin, and can oppose immunosuppressant medications used post transplant or for autoimmune disease.
This profile cites 2 human studies.
Study design details
Evidence Grade
Grade D: Preliminary / Theoretical Evidence
Evaluation of methodological rigor, population reach, and evidence alignment.
- Design Match
- Systematic review
- Risk of Bias
- Low
- Consistency
- Not assessed
Strongest recorded design is a systematic review, drawn from 2 recorded studies, 1 in people.
How evidence grades work
Each grade reflects the strength and consistency of published human evidence — not marketing claims. Grades are based on study count, design quality, effect size, consistency, and recency.
- Strong
- Multiple RCTs, consistent direction, adequate effect size
- Moderate
- Some RCTs or consistent observational data in humans
- Preliminary / Mixed
- Animal or in-vitro only, or conflicting human data
- Traditional / Theoretical
- Traditional use only; no controlled human trials
Clinical Study Summaries (1)0 human evidence sources · 0 human trials · Participant totals not consistently reported · Consistency not yet classifiable
What the evidence actually shows
This table contains 1 structured source, including 0 human evidence sources; 0 are human trials.
| Study | Design | N | Dose | Duration | Population | Outcome | Result & magnitude | Source |
|---|---|---|---|---|---|---|---|---|
Luz et al. · Medicinal Research Reviews · 2023 Background | Narrative review Summarizes selected literature without the full prespecified search and selection methods of a systematic review. | — | — | — | — | — | — | PubMed → |
Dosing & Timing
- No standardized dose
- Ganoderma lucidum; preclinical/mechanistic cognitive literature. No human dose/form claim from this source.
How Reishi Ganoderma Lucidum works
Simplified mechanism pathway based on preclinical and pharmacological evidence. Does not confirm clinical efficacy.
Mechanism Pathway — How Reishi Ganoderma Lucidum Works
CompoundTarget / ReceptorMechanismEffect / Outcome
Mechanisms & biological pathways (preclinical)
- Inflammatory Signaling Modulation
- Oxidative Stress Modulation
- Immune Signaling Modulation
- Stress Response Modulation
Active Compounds
Key constituents studied in Reishi Ganoderma Lucidum, with full pharmacology and safety profiles.
Compare related active botanicals
Explore botanicals with similar chemistry, effects, or safety considerations in the Botanical Activity Atlas.
Compare & Sourcing
Compare side-by-side tradeoffs or verify active marker guidelines.
Sourcing options
Reishi product picks
Recommendation status
Product recommendations are not shown for this profile because the current site safety and monetization policy does not permit them.
Product form & quality guidelines
When sourcing Reishi Ganoderma Lucidum, verify the label for:
- Standardized extract: Confirm active content percentages on the supplement facts panel (e.g. standardized to specific marker compounds) rather than simple raw herb weights.
- Third-party testing: Look for independent purity labels (USP, NSF, ConsumerLab, or Eurofins) to ensure the product is free from heavy metals, solvents, and contaminants.
- Form bioavailability: Ensure the form matches evidence-supported configurations (e.g. standardized active extracts like bacosides, withanolides, or curcuminoids) for optimal onset and digestion tolerance.
Safety first · Harm reduction
This information is educational and not medical advice. Start low, avoid risky combinations, and consult a licensed clinician before making health decisions—especially if you use medications, have diagnosed conditions, or are pregnant/breastfeeding.
Learn how we evaluate confidence, safety, and intensity on the methodology page.
Founder & Head Researcher · Oak Ridge, TN · Last reviewed August 2026
Editorial Review
Checked against primary sources, cited evidence, and contraindication language before publication. Evidence claims, safety language, and affiliate modules are reviewed independently. Not personal medical advice.
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