Herb Profile
Reishi Ganoderma Lucidum
Immune modulation.
Last reviewed: •2 human studies cited
D TraditionalUse extra caution — May increase bleeding risk when combined with anticoagulants, antiplatelets, or aspirin, and can oppose immunosuppressant medications used post transplant or for autoimmune disease. Details
- Evidence
- Moderate Human Evidence
- Typical onset
- Varies by prep
- Safety rating
- High caution
- Best for
- Sleep, Stress, Inflammatory signaling
- Avoid / review if
- Autoimmune Conditions (Caution), Bleeding Disorders, Anticoagulants
Monograph visual
Reishi Ganoderma Lucidum
The Hippie Scientist
Where to go next — guides & comparisons
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Safety & Cautions
May increase bleeding risk when combined with anticoagulants, antiplatelets, or aspirin, and can oppose immunosuppressant medications used post transplant or for autoimmune disease. Existing liver disease is a caution requiring medical supervision; rare liver enzyme elevation has been reported mainly at very high, prolonged doses.
28%
High caution — review carefully
Detailed safety fields
Pregnancy, breastfeeding, and contraindications
- - Autoimmune Conditions (Caution)
- - Bleeding Disorders
- - Anticoagulants
- - Immunosuppressants
Safety classifications
- - Liver-Sensitive: Liver-related caution language appears in the profile.
- - Anticoagulant Caution: Bleeding or anticoagulant-adjacent caution language is present.
Full safety note
- - May increase bleeding risk when combined with anticoagulants, antiplatelets, or aspirin, and can oppose immunosuppressant medications used post transplant or for autoimmune disease. Existing liver disease is a caution requiring medical supervision; rare liver enzyme elevation has been reported mainly at very high, prolonged doses. Mild dizziness, GI upset, or skin irritation are the most common side effects.
Safety labels
- - Liver-Sensitive
- - Anticoagulant Caution
Evidence-based safety
Caution when combined
These pairings share a flagged risk mechanism. They are additive-effect cautions derived from contraindication data, not confirmed clinical interactions. Consult a clinician before combining.
High-Priority Caution
147 flagged pairingsBleeding / anticoagulant risk
High-Priority Caution
147 flagged pairingsBleeding / anticoagulant risk
Browse the grouped cautions below. The list scrolls inside this card when long.
Bleeding / anticoagulant risk
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- Angelica Dahurica
- Angelica Pubescens
- Angelica Root
- Angelica Sinensis
- Arjuna
- Artemisia Capillaris
- Artichoke
- Ashitaba
- Ashitaba Extract
- Astaxanthin
- Berberis
- Black Seed
- Black Seed Oil
- Blueberry
- Boldo
- Boswellia
- Capsicum
- Caraway
- Carnitine L Tartrate
- Cayenne
- Chamomile
- Chinese Skullcap
- Chuanxiong
- Cissus
- Citicoline
- Clove
- Cnidium Monnieri
- Coleus Forskohlii
- Commiphora Mukul
- Coenzyme Q10
- Cordyceps
- Cranberry (Vaccinium macrocarpon)
- crocetin
- crocin
- cryptotanshinone
- Curcuma Wenyujin
- Curcumin
- Damiana
- Danshen
- Devils Claw Extract
- Dong Quai
- EGCG
- Epimedium
- Epimedium Brevicornum
- Evening Primrose (Oenothera biennis)
- Fenugreek
- Fenugreek Extract
- ferulic acid
- Feverfew
- Fisetin
- forskolin
- Fraxinus Rhynchophylla
- Fucoxanthin
- Galangal
- Reishi
- Garcinia Mangostana
- Garlic (Allium sativum)
- Garlic Aged Extract
- Garlic Extract
- Ginger (Zingiber officinale)
- Ginkgo
- Ginkgo Biloba Extract
- Ginkgo Extract EGb 761
- Panax Red Ginseng
- Panax White Ginseng
- ginsenoside rg3
- Glucosamine
- Goldenseal
- Lion's Mane
- Holy Basil / Tulsi (Ocimum tenuiflorum)
- Horse Chestnut
- hydroxytyrosol
- Japanese Knotweed
- Kudzu
- L-Carnitine
- Ligusticum Chuanxiong
- Magnolia
- Mangosteen
- Maral Root
- Chamomile
- Melatonin
- MSM
- Myrtle
- Nettle Root
- Nigella Sativa
- Noni
- Notoginseng
- Ocimum Basilicum
- Olive Leaf Extract
- Oregano
- Paeonia Lactiflora
- Asian Ginseng
- Panax Ginseng Extract
- Papaya Leaf
- Pastinaca Sativa
- Pau D'arco
- Perilla
- Phosphatidylserine
- Piper Longum
- Bifidobacterium Probiotic
- Lactobacillus Probiotic
- Probiotics - Bifidobacterium spp.
- Probiotics - Lactobacillus spp.
- Psoralea Corylifolia
- Pycnogenol
- Quercetin
- Quercetin Phytosome
- Red Clover
- Resveratrol
- Rhodiola Extract SHR-5
- Rose Hips
- Rosemary
- Saffron
- Saffron Extract
- Salvia miltiorrhiza
- Saw Palmetto (Serenoa repens)
- Saw Palmetto Extract
- Schisandra Berry
- Schisandra Chinensis
- Scutellaria Baicalensis
- Selaginella Tamariscina
- Soybean
- Syzygium Aromaticum
- Terminalia arjuna
- Thunder God Vine
- Thyme
- Tongkat Ali
- Trans-Resveratrol
- Fenugreek
- Tripterygium Wilfordii
- Turmeric (Curcuma longa)
- Turmeric Curcumin + Piperine
- Valerian
- Vitamin D3 + K2
- Grape
- White Peony
- Willow Bark Extract
- Yarrow
Evidence Summary
Evidence lens
Useful signal, but study design, dose, and population still matter.
ModerateModerate Human Evidence
Human clinical evidence: Present in source signals
Mechanistic / preclinical: Mechanism mapped — Inflammatory Signaling Modulation · Oxidative Stress Modulation · Immune Signaling Modulation
Research maturity: Preliminary or mixed — Long Term Human Evidence May Be Limited.
Safety boundary: Safety note available — May increase bleeding risk when combined with anticoagulants, antiplatelets, or aspirin, and can oppose immunosuppressant medications used post transplant or for autoimmune disease.
This profile cites 2 human studies.
How evidence grades work
Each grade reflects the strength and consistency of published human evidence — not marketing claims. Grades are based on study count, design quality, effect size, consistency, and recency.
A
Strong
Multiple RCTs, consistent direction, adequate effect size
B
Moderate
Some RCTs or consistent observational data in humans
C
Preliminary / Mixed
Animal or in-vitro only, or conflicting human data
D
Traditional / Theoretical
Traditional use only; no controlled human trials
Clinical Study Summaries (1)Cited studies informing this profile. RCTs and reviews shown first.
| Study | Type | Sample | Source |
|---|---|---|---|
Luz et al. (2023) | Mechanistic | — | Source → |
Dosing & Timing
Dose guidance
Ganoderma lucidum; preclinical/mechanistic cognitive literature. No human dose/form claim from this source.
How Reishi Ganoderma Lucidum Works
Simplified mechanism pathway based on preclinical and pharmacological evidence. Does not confirm clinical efficacy.
Mechanism Pathway — How Reishi Ganoderma Lucidum Works
CompoundTarget / ReceptorMechanismEffect / Outcome
Mechanisms & Biological Pathways
Preclinical pathways
Proposed mechanisms from in vitro and animal research; these do not confirm clinical outcomes in humans.
Inflammatory Signaling ModulationOxidative Stress ModulationImmune Signaling ModulationStress Response Modulation
Active Compounds
Key constituents studied in Reishi Ganoderma Lucidum, with full pharmacology and safety profiles.
Condition guides
Compare & Sourcing
Compare side-by-side tradeoffs or verify active marker guidelines.
Review available sources for Reishi Ganoderma Lucidum
Independent database mapping — evaluated separately from safety and efficacy scores.
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Affiliate-ready sourcing
Reishi product picks
Affiliate recommendations for Reishi Ganoderma Lucidum. Review safety, dose, and product quality before buying.
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Product Form & Quality Guidelines
When sourcing Reishi Ganoderma Lucidum, verify the label for:
- Standardized Extract: Confirm active content percentages on the supplement facts panel (e.g. standardized to specific marker compounds) rather than simple raw herb weights.
- Third-Party Testing: Look for independent purity labels (USP, NSF, ConsumerLab, or Eurofins) to ensure the product is free from heavy metals, solvents, and contaminants.
- Form Bioavailability: Ensure the form matches evidence-supported configurations (e.g. standardized active extracts like bacosides, withanolides, or curcuminoids) for optimal onset and digestion tolerance.
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Safety first · Harm reduction
This information is educational and not medical advice. Start low, avoid risky combinations, and consult a licensed clinician before making health decisions—especially if you use medications, have diagnosed conditions, or are pregnant/breastfeeding.
Learn how we evaluate confidence, safety, and intensity on the methodology page.
Editorial Review
Checked against primary sources, cited evidence, and contraindication language before publication. Evidence claims, safety language, and affiliate modules are reviewed independently. Not personal medical advice.
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Botanical profile context
How to interpret Reishi Ganoderma Lucidum
Reishi dosage ranges, effects, drug interactions, and harm-reduction safety guide for sleep. Moderate Human Evidence research evidence. Use this herb profile as a starting point for evidence review, not as a recommendation to start a new supplement. Botanical products can vary by plant part, extract ratio, standardization, dose, and contaminant testing, so two labels with the same common name may not behave the same way.
When reviewing Reishi Ganoderma Lucidum, compare the traditional-use context against the human evidence, mechanism notes, and safety cautions. Pay special attention to pregnancy, breastfeeding, liver or kidney disease, blood-pressure effects, sedation, stimulation, anticoagulant use, antidepressants, and any prescription medication overlap.
For product decisions, prefer transparent labels, named extracts, clear serving sizes, and third-party quality testing. Avoid treating a long list of possible mechanisms as proof that an herb will solve a specific condition.