Herb Profile
Salacia
Salacia reticulata
Salacia (Salacia reticulata) carries an editorial Grade B rating, but the studies recorded on this profile do not demonstrate that grade.
Last reviewed: •3 sources citedReport a correctionProfile-wide ·Unassigned
Standard caution — Mild GI symptoms Details
- Evidence
- Editorial Grade Not Demonstrated By Recorded Studies
- Typical onset
- Varies by prep
- Safety rating
- Low caution
- Best for
- Metabolic
- Avoid / review if
- Antidiabetics
Safety
Safety & Cautions
Mild GI symptoms
Standard caution
Caution level: Standard. No specific caution categories were detected in the source record.
Detailed safety fields
Pregnancy, breastfeeding, and contraindications
- Antidiabetics
Full safety note
- Mild GI symptoms
Evidence-based safety
Caution when combined
Severity and certainty are shown separately. A high-priority caution can still be theoretical: these pairings are screened from shared contraindication mechanisms and are not automatically documented clinical interactions. Provenance identifies the source fields that produced each flag; it does not upgrade the certainty of the pairwise claim.
Moderate Caution
110 flagged pairingsBlood-sugar lowering
Moderate Caution
110 flagged pairingsBlood-sugar lowering
Representative pairings are shown below. Large mechanism groups are intentionally summarized to keep profiles focused and crawl-efficient.
Blood-sugar loweringCertainty: Theoretical
Data provenance recorded for 110 of 110 pairings in this mechanism group.
- Acarbose — Theoretical interaction certainty
- ajoene — Theoretical interaction certainty
- Allicin — Theoretical interaction certainty
- Aloe Vera — Theoretical interaction certainty
- Alpha-Lipoic Acid — Theoretical interaction certainty
- American Ginseng Extract — Theoretical interaction certainty
- Andrographis — Theoretical interaction certainty
- Anemarrhena Asphodeloides — Theoretical interaction certainty
- Tarragon — Theoretical interaction certainty
- Ashoka — Theoretical interaction certainty
- Astragalus — Theoretical interaction certainty
- Astragalus Membranaceus — Theoretical interaction certainty
+98 more pairings share this mechanism. Use the Safety Checker to review a specific combination.
Evidence
Evidence Summary
Evidence lens
Treat this profile as unresolved until source review is complete.
Needs reviewEditorial Grade Not Demonstrated By Recorded Studies
Human clinical evidence: Not the primary signal
Mechanistic / preclinical: Mechanism mapped — Metabolic Regulation · Glucose Metabolism Support
Research maturity: Theoretical / mechanistic research — Mechanistic or unresolved evidence is kept separate from established human outcomes.
Safety boundary: Safety note available — Mild GI symptoms
This profile cites 3 human studies.
Study design details
Evidence Grade
Evidence grade not assigned
Evaluation of methodological rigor, population reach, and evidence alignment.
- Design Match
- Narrative review
- Risk of Bias
- High
- Consistency
- Not assessed
Strongest recorded design is a narrative review, drawn from 3 recorded studies, none of which measured an outcome in people.
How evidence grades work
Each grade reflects the strength and consistency of published human evidence — not marketing claims. Grades are based on study count, design quality, effect size, consistency, and recency.
- Strong
- Multiple RCTs, consistent direction, adequate effect size
- Moderate
- Some RCTs or consistent observational data in humans
- Preliminary / Mixed
- Animal or in-vitro only, or conflicting human data
- Traditional / Theoretical
- Traditional use only; no controlled human trials
Clinical Study Summaries (3)0 human evidence sources · 0 human trials · Participant totals not consistently reported · Consistency not yet classifiable
What the evidence actually shows
This table contains 3 structured sources, including 0 human evidence sources; 0 are human trials.
| Study | Design | N | Dose | Duration | Population | Outcome | Result & magnitude | Source |
|---|---|---|---|---|---|---|---|---|
Salacia spp.: recent insights on biotechnological interventions and future perspectives Chavan J et al. · Appl Microbiol Biotechnol · 2024 Background | Narrative review Summarizes selected literature without the full prespecified search and selection methods of a systematic review. | — | — | — | — | — | — | PubMed → |
Anti-diabetic and Anti-hyperlipidemic Effects and Safety of Salacia reticulata and Related Species Stohs SJ et al. · Phytother Res · 2015 Background | Narrative review Summarizes selected literature without the full prespecified search and selection methods of a systematic review. | — | — | — | — | — | — | PubMed → |
Salacia reticulata (Kothala himbutu) revisited; a missed opportunity to treat diabetes and obesity? Medagama AB et al. · Nutr J · 2015 Background | Narrative review Summarizes selected literature without the full prespecified search and selection methods of a systematic review. | — | — | — | — | — | — | PubMed → |
Dosing & Timing
- Dose guidance
- 240 1000 mg extract
How Salacia works
Simplified mechanism pathway based on preclinical and pharmacological evidence. Does not confirm clinical efficacy.
Mechanism Pathway — How Salacia Works
CompoundTarget / ReceptorMechanismEffect / Outcome
Mechanisms & biological pathways (preclinical)
- Metabolic Regulation
- Glucose Metabolism Support
Active Compounds
Key constituents studied in Salacia, with full pharmacology and safety profiles.
Compare related active botanicals
Explore botanicals with similar chemistry, effects, or safety considerations in the Botanical Activity Atlas.
Compare & Sourcing
Compare side-by-side tradeoffs or verify active marker guidelines.
Safety first · Harm reduction
This information is educational and not medical advice. Start low, avoid risky combinations, and consult a licensed clinician before making health decisions—especially if you use medications, have diagnosed conditions, or are pregnant/breastfeeding.
Learn how we evaluate confidence, safety, and intensity on the methodology page.
Founder & Head Researcher · Oak Ridge, TN · Last reviewed August 2026
Editorial Review
Checked against primary sources, cited evidence, and contraindication language before publication. Evidence claims, safety language, and affiliate modules are reviewed independently. Not personal medical advice.
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