Herb Profile

Shankhpushpi

It is best framed as a traditional cognitive support herb with limited modern clinical depth.

Last reviewed: June 6, 2026•3 human studies cited

C Preliminary

Safety Summary: Use extra caution — Generally well tolerated for most users.

Monograph visual

Shankhpushpi

Generated profile category visual

Key Findings

Primary reported uses

Cognitive Support
Nootropic
Neuroprotective
Stress

Preliminary

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Quick Stats

Evidence level

Limited Human Evidence

Typical onset

Varies by prep

Safety rating

Use extra caution: High caution

Best for

Cognitive Support, Nootropic, Neuroprotective

Avoid / review if

Pregnancy/Breastfeeding Without Clinician Supervision, Known Allergy To The Plant/Family, Potential Interaction Concern With Sedatives/CNS Depressants

Safety & Cautions

Generally well tolerated for most users.

28%

High caution — review carefully

Detailed safety fields

Medication interactions

- Potential Interaction Concern With Sedatives/CNS Depressants
- Use Clinician Review For High Dose Extracts Or Chronic Use.

Pregnancy, breastfeeding, and contraindications

- Pregnancy/Breastfeeding Without Clinician Supervision
- Known Allergy To The Plant/Family

Safety classifications

- Interaction-Aware: Medication or interaction context is explicitly noted.
- Pregnancy/Breastfeeding Caution: Pregnancy or breastfeeding caution language is present.

Full safety note

- Generally well tolerated for most users.

Safety labels

- Interaction-Aware
- Pregnancy/Breastfeeding Caution

Caution When Combined With

These pairings share a flagged risk mechanism. This is a mechanistic caution derived from contraindication data, not a confirmed clinical interaction — consult a clinician before combining.

Moderate Caution (57)

American Yellow LotusSedation / CNS depression
Both American Yellow Lotus and Shankhpushpi are flagged for sedation / CNS depression. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
Artemisia AbsinthiumSedation / CNS depression
Both Artemisia Absinthium and Shankhpushpi are flagged for sedation / CNS depression. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
Ashwagandha (Withania somnifera)Sedation / CNS depression
Both Ashwagandha (Withania somnifera) and Shankhpushpi are flagged for sedation / CNS depression. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
BacopaSedation / CNS depression
Both Bacopa and Shankhpushpi are flagged for sedation / CNS depression. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
Black SeedSedation / CNS depression
Both Black Seed and Shankhpushpi are flagged for sedation / CNS depression. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
Black TeaSedation / CNS depression
Both Black Tea and Shankhpushpi are flagged for sedation / CNS depression. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
Blue LotusSedation / CNS depression
Both Blue Lotus and Shankhpushpi are flagged for sedation / CNS depression. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
CalamusSedation / CNS depression
Both Calamus and Shankhpushpi are flagged for sedation / CNS depression. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
CatubaSedation / CNS depression
Both Catuba and Shankhpushpi are flagged for sedation / CNS depression. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
Chinese SkullcapSedation / CNS depression
Both Chinese Skullcap and Shankhpushpi are flagged for sedation / CNS depression. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
Coriandrum SativumSedation / CNS depression
Both Coriandrum Sativum and Shankhpushpi are flagged for sedation / CNS depression. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
CorydalisSedation / CNS depression
Both Corydalis and Shankhpushpi are flagged for sedation / CNS depression. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
Cymbopogon CitratusSedation / CNS depression
Both Cymbopogon Citratus and Shankhpushpi are flagged for sedation / CNS depression. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
DamianaSedation / CNS depression
Both Damiana and Shankhpushpi are flagged for sedation / CNS depression. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
California PoppySedation / CNS depression
Both California Poppy and Shankhpushpi are flagged for sedation / CNS depression. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
EucalyptusSedation / CNS depression
Both Eucalyptus and Shankhpushpi are flagged for sedation / CNS depression. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
GastrodiaSedation / CNS depression
Both Gastrodia and Shankhpushpi are flagged for sedation / CNS depression. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
Gotu Kola (Centella asiatica)Sedation / CNS depression
Both Gotu Kola (Centella asiatica) and Shankhpushpi are flagged for sedation / CNS depression. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
HopsSedation / CNS depression
Both Hops and Shankhpushpi are flagged for sedation / CNS depression. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
Hypericum PerforatumSedation / CNS depression
Both Hypericum Perforatum and Shankhpushpi are flagged for sedation / CNS depression. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
JatamansiSedation / CNS depression
Both Jatamansi and Shankhpushpi are flagged for sedation / CNS depression. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
JujubeSedation / CNS depression
Both Jujube and Shankhpushpi are flagged for sedation / CNS depression. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
LavenderSedation / CNS depression
Both Lavender and Shankhpushpi are flagged for sedation / CNS depression. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
Lavender ExtractSedation / CNS depression
Both Lavender Extract and Shankhpushpi are flagged for sedation / CNS depression. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
Lemon Balm ExtractSedation / CNS depression
Both Lemon Balm Extract and Shankhpushpi are flagged for sedation / CNS depression. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
Lemon VerbenaSedation / CNS depression
Both Lemon Verbena and Shankhpushpi are flagged for sedation / CNS depression. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
LemongrassSedation / CNS depression
Both Lemongrass and Shankhpushpi are flagged for sedation / CNS depression. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
Lobelia InflataSedation / CNS depression
Both Lobelia Inflata and Shankhpushpi are flagged for sedation / CNS depression. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
LonganSedation / CNS depression
Both Longan and Shankhpushpi are flagged for sedation / CNS depression. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
MagnoliaSedation / CNS depression
Both Magnolia and Shankhpushpi are flagged for sedation / CNS depression. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
MelatoninSedation / CNS depression
Both Melatonin and Shankhpushpi are flagged for sedation / CNS depression. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
Lemon BalmSedation / CNS depression
Both Lemon Balm and Shankhpushpi are flagged for sedation / CNS depression. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
Milk OatsSedation / CNS depression
Both Milk Oats and Shankhpushpi are flagged for sedation / CNS depression. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
MugwortSedation / CNS depression
Both Mugwort and Shankhpushpi are flagged for sedation / CNS depression. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
Muira PuamaSedation / CNS depression
Both Muira Puama and Shankhpushpi are flagged for sedation / CNS depression. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
Myristica FragransSedation / CNS depression
Both Myristica Fragrans and Shankhpushpi are flagged for sedation / CNS depression. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
Nicotiana GlaucaSedation / CNS depression
Both Nicotiana Glauca and Shankhpushpi are flagged for sedation / CNS depression. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
Nicotiana TabacumSedation / CNS depression
Both Nicotiana Tabacum and Shankhpushpi are flagged for sedation / CNS depression. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
OatstrawSedation / CNS depression
Both Oatstraw and Shankhpushpi are flagged for sedation / CNS depression. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
Ocimum BasilicumSedation / CNS depression
Both Ocimum Basilicum and Shankhpushpi are flagged for sedation / CNS depression. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
ParsleySedation / CNS depression
Both Parsley and Shankhpushpi are flagged for sedation / CNS depression. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
PassionflowerSedation / CNS depression
Both Passionflower and Shankhpushpi are flagged for sedation / CNS depression. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
Passionflower ExtractSedation / CNS depression
Both Passionflower Extract and Shankhpushpi are flagged for sedation / CNS depression. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
PolygalaSedation / CNS depression
Both Polygala and Shankhpushpi are flagged for sedation / CNS depression. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
PoriaSedation / CNS depression
Both Poria and Shankhpushpi are flagged for sedation / CNS depression. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
Raspberry LeafSedation / CNS depression
Both Raspberry Leaf and Shankhpushpi are flagged for sedation / CNS depression. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
SageSedation / CNS depression
Both Sage and Shankhpushpi are flagged for sedation / CNS depression. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
Schisandra BerrySedation / CNS depression
Both Schisandra Berry and Shankhpushpi are flagged for sedation / CNS depression. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
Schisandra ChinensisSedation / CNS depression
Both Schisandra Chinensis and Shankhpushpi are flagged for sedation / CNS depression. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
Scutellaria BaicalensisSedation / CNS depression
Both Scutellaria Baicalensis and Shankhpushpi are flagged for sedation / CNS depression. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
SkullcapSedation / CNS depression
Both Skullcap and Shankhpushpi are flagged for sedation / CNS depression. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
Sophora FlavescensSedation / CNS depression
Both Shankhpushpi and Sophora Flavescens are flagged for sedation / CNS depression. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
Valeriana officinalisSedation / CNS depression
Both Shankhpushpi and Valeriana officinalis are flagged for sedation / CNS depression. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
Valerian Root ExtractSedation / CNS depression
Both Shankhpushpi and Valerian Root Extract are flagged for sedation / CNS depression. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
ValerianSedation / CNS depression
Both Shankhpushpi and Valerian are flagged for sedation / CNS depression. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
Verbena OfficinalisSedation / CNS depression
Both Shankhpushpi and Verbena Officinalis are flagged for sedation / CNS depression. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.
WormwoodSedation / CNS depression
Both Shankhpushpi and Wormwood are flagged for sedation / CNS depression. Combining them may have an additive effect. This is a mechanistic caution, not a verified interaction — consult a clinician before stacking.

Evidence Summary

Preliminary

Evidence lens

What kind of evidence supports this profile?

Early signal that needs stronger human replication before practical claims.

PreliminaryLimited Human Evidence

Human clinical evidence

Present in source signals

Human or clinical-study language is present in the reviewed fields.

Mechanistic / preclinical

Mechanism mapped

Stress Response Modulation | Neuroprotective Activity

Research maturity

Preliminary or mixed

Long Term Human Evidence May Be Limited.

Safety boundary

Safety note available

Generally well tolerated for most users.

This profile cites 3 human studies.

▶How evidence grades work

Each grade reflects the strength and consistency of published human evidence — not marketing claims. Grades are based on study count, design quality, effect size, consistency, and recency.

Strong

Multiple RCTs, consistent direction, adequate effect size

Moderate

Some RCTs or consistent observational data in humans

Preliminary / Mixed

Animal or in-vitro only, or conflicting human data

Traditional / Theoretical

Traditional use only; no controlled human trials

Clinical Study Summaries

3 cited studies informing this profile. RCTs and reviews shown first.

Study	Type	Sample	Source
Neuroprotective Herbs for the Management of Alzheimer's Disease Gregory J et al. (2021)	—	—	—
Role of Shankhpushpi (Convolvulus pluricaulis) in neurological disorders: An umbrella review covering evidence from ethnopharmacology to clinical studies Sharma R et al. (2022)	—	—	—
An update on Shankhpushpi, a cognition-boosting Ayurvedic medicine Sethiya NK et al. (2009)	—	—	—

Study

Type

Sample

Source

Neuroprotective Herbs for the Management of Alzheimer's Disease

Gregory J et al. (2021)

—

Role of Shankhpushpi (Convolvulus pluricaulis) in neurological disorders: An umbrella review covering evidence from ethnopharmacology to clinical studies

Sharma R et al. (2022)

—

An update on Shankhpushpi, a cognition-boosting Ayurvedic medicine

Sethiya NK et al. (2009)

—

Dosing & Timing

Dose guidance

Preparation specific; use standardized product label for Preparation varies by tradition and product form and require source backed dosage review before therapeutic claims.

How Shankhpushpi Works

Simplified mechanism pathway based on preclinical and pharmacological evidence. Does not confirm clinical efficacy.

Mechanism Pathway — How Shankhpushpi Works

CompoundTarget / ReceptorMechanismEffect / Outcome

Mechanisms & Biological Pathways

Preclinical pathways

Proposed mechanisms from in vitro and animal research; these do not confirm clinical outcomes in humans.

Stress Response ModulationNeuroprotective Activity

Condition guides

Focus Stress Anxiety Blood pressure Cognition

Compare & Sourcing

Compare side-by-side tradeoffs or verify active marker guidelines.

Sourcing Options

Review available sources for Shankhpushpi

Independent database mapping. Sourcing availability is evaluated separately from safety and clinical efficacy scores.

Check sourcing options

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Safety first · Harm reduction

This information is educational and not medical advice. Start low, avoid risky combinations, and consult a licensed clinician before making health decisions—especially if you use medications, have diagnosed conditions, or are pregnant/breastfeeding.

Learn how we evaluate confidence, safety, and intensity on the methodology page.

Editorial Review

Reviewed against source evidence and safety constraints

Profiles are checked against primary sources, cited evidence, and contraindication language before publication. This is editorial review, not personal medical advice or a named clinician endorsement.

Evidence claims are matched to human, mechanistic, or traditional-use context.

Safety language is kept conservative when interaction or population data is incomplete.

Affiliate modules are separated from evidence ratings and caution language.

Editorial Process: We synthesize preclinical pharmacology, human clinical data, and source registry context while preserving uncertainty and avoiding commercial hype.

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Botanical profile context

How to interpret Shankhpushpi

Shankhpushpi dosage ranges, effects, drug interactions, and harm-reduction safety guide for cognitive support. Limited Human Evidence research evidence. Use this herb profile as a starting point for evidence review, not as a recommendation to start a new supplement. Botanical products can vary by plant part, extract ratio, standardization, dose, and contaminant testing, so two labels with the same common name may not behave the same way.

When reviewing Shankhpushpi, compare the traditional-use context against the human evidence, mechanism notes, and safety cautions. Pay special attention to pregnancy, breastfeeding, liver or kidney disease, blood-pressure effects, sedation, stimulation, anticoagulant use, antidepressants, and any prescription medication overlap.

For product decisions, prefer transparent labels, named extracts, clear serving sizes, and third-party quality testing. Avoid treating a long list of possible mechanisms as proof that an herb will solve a specific condition.