Herb Profile
Chamomile
Matricaria chamomilla
Sleep meta analysis reports PSQI improvement and some sleep onset/awakening improvements, but limited objective data; oral anxiety review found most included studies reported anxiety reduction.
Last reviewed: •7 sources citedReport a correctionProfile-wide ·B Moderate
Use extra caution — May support sleep quality and calm/anxiety symptoms; evidence is supportive but not definitive. Details
- Evidence
- Moderate Evidence
- Typical onset
- Varies by prep
- Safety rating
- Moderate caution
- Best for
- Sleep, Stress
- Avoid / review if
- Anticoagulants (Coumarin Content)
Safety
Safety & Cautions
May support sleep quality and calm/anxiety symptoms; evidence is supportive but not definitive. | Do not claim it treats insomnia or anxiety disorders; do not imply sleep duration/efficiency improvements are consistent.
Elevated caution
Caution level: Elevated. One caution category applies — read it before use.
- Stimulant-Like ProfileStimulant-like or activating caution language is present.
Detailed safety fields
Pregnancy, breastfeeding, and contraindications
- Anticoagulants (Coumarin Content)
Safety classifications
- Stimulant-Like Profile: Stimulant-like or activating caution language is present.
Full safety note
- May support sleep quality and calm/anxiety symptoms; evidence is supportive but not definitive. | Do not claim it treats insomnia or anxiety disorders; do not imply sleep duration/efficiency improvements are consistent. | Use as beginner friendly sleep/anxiety page with allergy and objective evidence caveats.
Safety labels
- Stimulant-Like Profile
Evidence-based safety
Caution when combined
Severity and certainty are shown separately. A high-priority caution can still be theoretical: these pairings are screened from shared contraindication mechanisms and are not automatically documented clinical interactions. Provenance identifies the source fields that produced each flag; it does not upgrade the certainty of the pairwise claim.
High-Priority Caution
147 flagged pairingsBleeding / anticoagulant risk
High-Priority Caution
147 flagged pairingsBleeding / anticoagulant risk
Representative pairings are shown below. Large mechanism groups are intentionally summarized to keep profiles focused and crawl-efficient.
Bleeding / anticoagulant riskCertainty: Theoretical
Data provenance recorded for 147 of 147 pairings in this mechanism group.
- aescin — Theoretical interaction certainty
- Aged Garlic Extract — Theoretical interaction certainty
- ajoene — Theoretical interaction certainty
- Ajwain — Theoretical interaction certainty
- Allicin — Theoretical interaction certainty
- Garlic — Theoretical interaction certainty
- American Ginseng Extract — Theoretical interaction certainty
- Andrographis — Theoretical interaction certainty
- Angelica Archangelica — Theoretical interaction certainty
- Angelica Dahurica — Theoretical interaction certainty
- Angelica Pubescens — Theoretical interaction certainty
- Angelica Root — Theoretical interaction certainty
+135 more pairings share this mechanism. Use the Safety Checker to review a specific combination.
Evidence
Evidence Summary
Evidence lens
Useful signal, but study design, dose, and population still matter.
ModerateModerate Evidence
Human clinical evidence: Present in source signals
Mechanistic / preclinical: Mechanism mapped — Stress Response Modulation
Research maturity: Established research — Long Term Human Evidence May Be Limited.
Safety boundary: Safety note available — May support sleep quality and calm/anxiety symptoms; evidence is supportive but not definitive.
This profile cites 7 human studies.
Study design details
Evidence Grade
Grade B: Moderate Evidence
Evaluation of methodological rigor, population reach, and evidence alignment.
- Design Match
- Meta-analysis
- Risk of Bias
- Low
- Consistency
- Consistent
Strongest recorded design is a meta-analysis, drawn from 8 recorded studies, 5 in people. No disagreement is recorded across them.
How evidence grades work
Each grade reflects the strength and consistency of published human evidence — not marketing claims. Grades are based on study count, design quality, effect size, consistency, and recency.
- Strong
- Multiple RCTs, consistent direction, adequate effect size
- Moderate
- Some RCTs or consistent observational data in humans
- Preliminary / Mixed
- Animal or in-vitro only, or conflicting human data
- Traditional / Theoretical
- Traditional use only; no controlled human trials
Clinical Study Summaries (7)4 human evidence sources · 0 human trials · Participant totals not consistently reported · Consistency not yet classifiable
Filter by study class
Showing 7 of 7 studies.
What the evidence actually shows
This table contains 7 structured sources, including 4 human evidence sources; 0 are human trials.
| Study | Design | N | Dose | Duration | Population | Outcome | Result & magnitude | Source |
|---|---|---|---|---|---|---|---|---|
Asma Kazemi; S. Shojaei-Zarghani; Parham Eskandarzadeh; Mohammad Hashem Hashempur · Complementary Therapies in Medicine · 2024 Background | Meta-analysis Statistically combines results from multiple eligible studies; confidence still depends on the quality, consistency, and directness of those studies. | — | — | — | — | — | — | Source → |
Background | Meta-analysis Statistically combines results from multiple eligible studies; confidence still depends on the quality, consistency, and directness of those studies. | — | — | — | — | — | Chamomile improved subjective sleep quality and some sleep-initiation/maintenance measures. | PubMed → |
Background | Meta-analysis Statistically combines results from multiple eligible studies; confidence still depends on the quality, consistency, and directness of those studies. | — | — | — | — | — | A 2019 synthesis did not show a uniform anxiety benefit across all populations and outcomes, although selected generalized-anxiety-disorder or timepoint analyses were more favorable. The indication and subgroup boundaries should remain visible. | PubMed → |
Warfarin and food, herbal or dietary supplement interactions: A systematic review Tan CSS et al. · Br J Clin Pharmacol · 2021 Background | Systematic review Uses a predefined method to find and evaluate relevant studies, but may or may not pool their results statistically. | — | — | — | — | — | — | PubMed → |
Anti-Inflammatory and Skin Barrier Repair Effects of Topical Application of Some Plant Oils Lin TK et al. · Int J Mol Sci · 2017 Background | Narrative review Summarizes selected literature without the full prespecified search and selection methods of a systematic review. | — | — | — | — | — | — | PubMed → |
Dai YL et al. · Molecules · 2022 Background | Narrative review Summarizes selected literature without the full prespecified search and selection methods of a systematic review. | — | — | — | — | — | — | PubMed → |
Show 1 more study
The Effect of Oral Chamomile on Anxiety: A Systematic Review of Clinical Trials Sogand Saadatmand; Foad Zohroudi; Hadith Tangestani · Clinical Nutrition Research · 2024 Background | Narrative review Summarizes selected literature without the full prespecified search and selection methods of a systematic review. | — | — | — | — | — | — | PubMed → |
Dosing & Timing
- No standardized dose
- Dose/form varies widely across tea, extract, capsule, and inhalation studies. Use source specific dose when known. | Oral chamomile and chamomile preparations; aromatherapy evidence is separate and should not be merged with oral extract/tea.
How Chamomile works
Simplified mechanism pathway based on preclinical and pharmacological evidence. Does not confirm clinical efficacy.
Mechanism Pathway — How Chamomile Works
CompoundTarget / ReceptorMechanismEffect / Outcome
Mechanisms & biological pathways (preclinical)
- Stress Response Modulation
Active Compounds
Key constituents studied in Chamomile, with full pharmacology and safety profiles.
Compare related active botanicals
Explore botanicals with similar chemistry, effects, or safety considerations in the Botanical Activity Atlas.
Compare & Sourcing
Compare side-by-side tradeoffs or verify active marker guidelines.
Review available sources for Chamomile
Independent database mapping — evaluated separately from safety and efficacy scores.
Affiliate disclosure: Shopping links may earn this site a commission at no cost to you. Links are chosen on quality and availability, never commission tiers; safety warnings and evidence ratings stay independent.
Safety first · Harm reduction
This information is educational and not medical advice. Start low, avoid risky combinations, and consult a licensed clinician before making health decisions—especially if you use medications, have diagnosed conditions, or are pregnant/breastfeeding.
Learn how we evaluate confidence, safety, and intensity on the methodology page.
Founder & Head Researcher · Oak Ridge, TN · Last reviewed August 2026
Editorial Review
Checked against primary sources, cited evidence, and contraindication language before publication. Evidence claims, safety language, and affiliate modules are reviewed independently. Not personal medical advice.
Help improve this profile
Was this useful for your research?
These controls record only the page and the structured choice you make when analytics consent is enabled. Please don’t include personal medical information in research requests.
Was this evidence summary clear?
Did you find what you were researching?
Free safety checklist
Get the Chamomile research notes
Evidence summaries, dosing context, and safety updates for this herb — straight to your inbox.
We use your email to send the checklist and occasional evidence-first supplement updates. Unsubscribe anytime. Privacy policy.